Bøger i Handbooks in Pharmacology and Toxicology serien

Provides both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. The book discusses approaches to pharmaceutical development, including biological technologies currently used by some of the world's foremost labs.

This reference covers new concepts for old problems - airway hyperresponsiveness, chronic inflammation and asthma.

Brings together various aspects of TAXOL[registered] research, development, and clinical use. This volume provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production.

This reference covers approaches to studying the process of pathogenesis, pathophysiology and healing of GI mucosal lesions associated with inflammation. Techniques employing gastric and colonic cells in culture are included.

Presents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides immunological methods that can be utilized by researchers or practitioners who want to enhance the application of this science.

Two anabolic agents, the parathyroid hormone (PTH) and the fluoride ion, show promise in the treatment of osteoporosis. Covering the science, and including clinical trial data, this work provides an assessment of the prospects for these agents as osteoporosis therapeutics.

Explores several subtypes of muscarinic receptors that modulate smooth muscle activity. This book contains topics such as a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, and the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle.

Offers an overview of the methodologies being applied to drug design and in-depth analyses of progress in specific fields. This book details various approaches to pharmaceutical development.

This text on endothelin receptors covers important advances, from the intracellular level of the nucleus to the functional effects that endothelin receptors mediate. Clinical applications of techniques are provided.

Featuring contributions from researchers in the diverse fields of neuroinjury, myocardial injury, diabetes, shock, and inflammation, this text examines the status of the field of poly (ADP-ribose) polymerase (PARP) and cell death. It also explores PARP and apoptosis, PARP and DNA repair, as well as PARP and regulation of gene expression.

Offers reviews and summaries regarding articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. This book contains topics including pharmacological and biochemical regulation of the airways, involvement of key inflammatory cells and the release and effect of their mediators in airway function.

Serotonin and Gastrointestinal Function provides a comprehensive review of current research into the mechanisms by which serotonin acts on gastrointestinal tissues

Offers an overview of the state of knowledge about anesthetic mechanisms at the molecular level of occurrence, focusing on the techniques that relate to how anesthetic drugs cause unconsciousness. This book provides a survey of anesthetic actions, including hyperbaric pressure and anesthesia and volatile anesthetic interactions with proteins.