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Thisvolumecontainstheproceedingsofthe?rstinternationalmeetingonFormal Methods in Systems Biology, held at Microsoft Research, Cambridge, UK, June 4-5, 2008. While there are several venues that cover computational methods in systems biology,there is to date no single conference that brings together the application of the range of formal methods in biology. Therefore, convening such a meeting could prove extremely productive. The purpose of this meeting was to identify techniques for the speci?cation, development and veri?cation of biological m- els.Italsofocusedonthedesignoftoolstoexecuteandanalyzebiologicalmodels in ways that can signi?cantly advance our understanding of biological systems. As a forum for this discussion we invited key scientists in the area of formal methods to this unique meeting. Although this was a one-o? meeting, we are exploring the possibility of this forming the ?rst of what might become an annual conference. Presentations at the meeting were by invitation only; future meetings are expected to operate on a submission and review basis. The Steering Committee and additional referees reviewed the invited papers. Each submission was evaluated by at least two referees. The volume includes nine invited contributions. Formal Methods in Systems Biology 2008 was made possible by the cont- bution and dedication ofmany people. First of all,we wouldlike to thank allthe authors who submitted papers. Secondly, we would like to thank our additional invited speakers and participants. We would also like to thank the members of the Steering Committee for their valuable comments. Finally, we ackno- edge the help of the administrative and technical sta? at the MicrosoftResearch Cambridge lab.

This volume contains the papers presented at RECOMB 2010: the 14th Annual International Conference on Research in Computational Molecular Biology held in Lisbon, Portugal, during April 25-28, 2010. The RECOMB conference series was started in 1997 by Sorin Istrail, Pavel Pevzner, and Michael Waterman. RECOMB 2010 was hosted by INESC-ID and Instituto Superior Tecnico, or- nized by a committee chaired by Arlindo Oliveira and took place at the Int- national Fair of Lisbon Meeting Centre. This year, 36 papers were accepted for presentation out of 176 submissions. The papers presented were selected by the Program Committee (PC) assisted by a number of external reviewers. Each paper was reviewed by three members of the PC, or by external reviewers, and there was an extensive Web-based discussion over a period of two weeks, leading to the ?nal decisions. RECOMB 2010 also introduced a Highlights Track, in which six additional presentations by senior authors were chosen from papers published in 2009. The RECOMB conferenceseriesiscloselyassociatedwiththeJournalofComputational Biology, which traditionally publishes special issues devoted to presenting full versions of selected conference papers.

This book constitutes the refereed proceedings of the 13th International Workshop on Algorithms in Bioinformatics, WABI 2013, held in Sophia Antipolis, France, in September 2013. WABI 2013 is one of seven workshops which, along with the European Symposium on Algorithms (ESA), constitute the ALGO annual meeting and highlights research in algorithmic work for bioinformatics, computational biology and systems biology. The goal is to present recent research results, including significant work-in-progress, and to identify and explore directions of future research. The 27 full papers presented were carefully reviewed and selected from 61 submissions. The papers cover all aspects of algorithms in bioinformatics, computational biology and systems biology.

This book constitutes the refereed proceedings of the 10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014, held in Zhangjiajie, China, in June 2014. The 33 revised full papers and 31 one-page abstracts included in this volume were carefully reviewed and selected from 119 submissions. The papers cover a wide range of topics in bioinformatics and computational biology and their applications including the development of experimental or commercial systems.

This book constitutes the refereed proceedings of the 10th International Conference on Data Integration in the Life Sciences, DILS 2014, held in Lisbon, Portugal, in July 2014. The 9 revised full papers and the 5 short papers included in this volume were carefully reviewed and selected from 20 submissions. The papers cover a range of important topics such as data integration platforms and applications; biodiversity data management; ontologies and visualization; linked data and query processing.

This book constitutes the refereed proceedings of the 8th International Conference on Data Integration in the Life Sciences, DILS 2012, held in College Park, MD, USA, on June 28-29, 2012. The 11 revised papers included in this volume were carefully reviewed and selected. The papers cover the following topics: foundations of data integration, new paradigms for data integration, and integrating clinical data.

This book constitutes the refereed proceedings of the 7th Brazilian Symposium on Bioinformatics, BSB 2012, held in Campo Grande, Brazil, in August 2012. The 16 regular papers presented were carefully reviewed and selected for inclusion in this book. It also contains a joint paper from two of the guest speakers. The Brazilian Symposium on Bioinformatics covers all aspects of bioinformatics and computational biology, including sequence analysis; motifs, and pattern matching; biological databases, data management, data integration, and data mining; biomedical text mining; structural, comparative, and functional genomics; personal genomics; protein structure, modeling, and simulation; gene identification, regulation and expression analysis; gene and protein interaction and networks; molecular docking; molecular evolution and phylogenetics; computational systems biology; computational proteomics; statistical analysis of molecular sequences; algorithms for problems in computational biology; applications in molecular biology, biochemistry, genetics, medicine, microbiology and associated subjects.

This book constitutes the revised selected proceedings of Second International Symposium on Biomedical and Computational Biology, BECB 2022, held as a virtual event in August 2022.The 58 full papers included in this book were carefully reviewed and selected from 135 submissions. The papers are organized in topical sections as follows: The Charge Transfer Network Model for Arbitrary Proteins Complexes; A Self-Supervised 3D/2D Registration Method for Incomplete DSA Vessels; The Potential Role of RNA "Writer" TRMT61B in the Immune Regulation of Breast Cancer; Extraction, Composition Analysis and Blood Lipid Lowering Activity of Rana chensinensis Ovum Oil.

This book constitutes the refereed proceedings of the 27th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2023, held in Istanbul, Turkey, during April 16¿19, 2023.The 11 regular and 33 short papers presented in this book were carefully reviewed and selected from 188 submissions. The papers report on original research in all areas of computational molecular biology and bioinformatics.

This book constitutes the refereed proceedings of the 20th Annual RECOMB Satellite Workshop on Comparative Genomics, RECOMB-CG 2023 which took place in Istanbul, Turkey, in April 2023. The 15 full papers included in this book were carefully reviewed and selected from 25 submissions. The papers present cutting edge research in comparative genomics, with an emphasis on computational approaches and novel experimental results.Chapters "Inferring Clusters of Orthologous and Paralogous Transcripts" and "Gene Order Phylogeny via Ancestral Genome Reconstruction under Dollo" are published Open Access under Creative Commons Attribution license (CC BY 4.0).

This book constitutes the refereed proceedings of the 21st International Conference on Computational Methods in Systems Biology, CMSB 2023, held in Luxembourg City, Luxembourg, during September 13¿15, 2023.The 14 full papers and 3 tool papers presented in this book were carefully reviewed and selected from 28 submissions. CMSB focuses on modeling, simulation, analysis, design and control of biological systems and covers the broad field of computational methods and tools in systems and synthetic biology and their applications.

This book constitutes the refereed proceedings of the 19th International Symposium on Bioinformatics Research and Applications, ISBRA 2023, held in Wroc¿aw, Poland, during October 9¿12, 2023.The 28 full papers and 16 short papers included in this book were carefully reviewed and selected from 89 submissions. They were organized in topical sections as follows: reconciling inconsistent molecular structures from biochemical databases; radiology report generation via visual recalibration and context gating-aware; sequence-based nanobody-antigen binding prediction; and hist2Vec: kernel-based embeddings for biological sequence classification.

This book constitutes the refereed proceedings of the 20th International Conference on Computational Methods in Systems Biology, CMSB 2022, held in Bucharest, Romania, in September 2022.The 13 full papers and 4 tool papers were carefully reviewed and selected from 43 submissions. CMSB focuses on modeling, simulation, analysis, design and control of biological systems. The papers are arranged thematically as follows: Chemical reaction networks; Boolean networks; continuous and hybrid models; machine learning; software.

This book constitutes revised selected papers from the refereed proceedings of the 11th International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2021, held as a virtual event during December 16-18, 2021.The 13 full papers included in this book were carefully reviewed and selected from 17 submissions. They were organized in topical sections as follows: Computational advances in bio and medical sciences; and computational advances in molecular epidemiology.