Medicinsk forskning

The human brain can actually grow?and a bigger brain means better memory, creativity, speed of learning, and ability to concentrate.In Boost Your Brain, Majid Fotuhi, M.D., Ph.D., guides you through the innovative brain fitness program that he has developed for his patients at the NeurExpand Brain Center, an institute dedicated to helping people quickly sharpen their brain performance. You start the program with an assessment of your current brain health and then are given specific brain-fit strategies proven to promote brain acuity and longevity, detailing the latest scientific evidence behind each. Concrete advice is given on how to spur new cell growth, which foods help to build new synapses, what creates brain reserve, and more. Dr. Fotuhi also highlights key behaviors to avoid?explaining, for example, how one common sleep disorder can shrink your brain's memory and attention centers by as much as 18 percent!Dr. Fotuhi brings together the latest brain science discoveries about neuroplasticity, which show not only that the size of the brain can be increased within a matter of weeks?resulting in better focus, memory, and creativity?but that the increase can be scientifically measured. Boost Your Brain is the only book that uses groundbreaking advances in neuroscience to present a clear explanation and prescriptive plan for how to access the benefits of significantly enhanced brain performance?at any age.

Der Anregung der Verlagsbuchhandlung, ein Lehrbuch der chemischen Physiologie zu verfassen, bin ich im Jahre 1936 gern nachgekommen, weil es mir reizvoll erschien, Tatsachenmaterial und theoretische Vor- stellungen dieser Wissenschaft vor allem im Sinne einer allgemeinen bio- logischen Chemie zu ordnen und zusammenzufassen. Voraussetzung dafur schien mir eine eingehende Abhandlung der deskriptiven Biochemie, also eine Beschreibung der chemischen Stoffe, die von biologischer Bedeutung sind. Aber eine solche "e;chemische Anatomie"e; ist Beginn, nicht Ziel der chemischen Physiologie. Dieses liegt vielmehr in der Erforschung der physiologischen Vorgange, soweit sie chemischer Natur oder mit chemischen Methoden fabar sind. Da die Zellen und Organe, der Schauplatz dieser Vorgange, physikochemischen Gesetzmaigkeiten unterworfen sind, wurden diese wenigstens in ihren Grundzugen behandelt. Zellen und Organe ver- fugen uber besondere ehe mische Werkzeuge, die sie zu ihren biologischen Leistungen befahigen und die wir als Wirkstoffe bezeichnen. Auf eine ein- gehende Darstellung gerade dieser Stoffe und ihrer Wirkungen wurde be- sonderer Wert gelegt, da uns ihre Funktion am ehesten einen Einblick in die Werkstatt des Lebens gestattet. Schlielich war zu zeigen, in welcher Weise der Organismus und seine Organe die Korperbausteine umformen, um die in ihnen gebundene Energie in Freiheit zu setzen und nutzbar zu machen; es war daher in besonderen Abschnitten der inter- mediare Stoffwechsel und der Stoffwechsel einiger Organe abzuhandeln.

KOMPENDIUM I MIKROBIOLOGI OG INFEKTIONSMEDICIN2. udgaveDette kompendium er skrevet af de samme forfattere, som er ansvarlige for lærebogen Klinisk mikrobiologi og infektionsmedicin 5. udgave, FADL’s Forlag (2021). Kompendiet er en forkortet version af den store grundbog, hvor de vigtigste fakta er trukket frem.Bogen imødekommer et behov hos de studerende på de danske medicinske fakulteter for en komprimeret tekst og mnemotekniske oversigtsskemaer, som kan bruges til at få et hurtigt overblik over stoffet.Kompendiet er en uundværlig ledsager, bl.a. i forbindelse med eksamensforberedelserne.Emner:Generel bakteriologiSystematisk bakteriologiKlinisk bakteriologi, infektionshygiejne og antibiotikabehandlingGenerel virologiSystematisk virologiMykologiParasitologiInfektionsmedicinske principper og strategier

Machine learning is a novel discipline concerned with the analysis of large and multiple variables data. It involves computationally intensive methods, like factor analysis, cluster analysis, and discriminant analysis. It is currently mainly the domain of computer scientists, and is already commonly used in social sciences, marketing research, operational research and applied sciences. It is virtually unused in clinical research. This is probably due to the traditional belief of clinicians in clinical trials where multiple variables are equally balanced by the randomization process and are not further taken into account. In contrast, modern computer data files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required. This book was written as a hand-hold presentation accessible to clinicians, and as a must-read publication for those new to the methods.

Hepatitis Delta Virus is an up-to-date guide to hepatitis D virus (HDV), a human virus with a number of distinctive features. Each chapter of this book describes one of the broad aspects of HDV from virology to molecular biology, and from diagnosis to therapy.

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity currently provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulates the hosts immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host. From the early stages of binding and receptors-mediated signalling, to new paradigms by which heat shock proteins are released into the circulation, to antigen processing and presentation, and finally to the immune response itself this book is a must read for graduate and postgraduates in the field of Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Mammalian and Avian Transgenesis presents a collection of novel methods for the production of a wide range of transgenic animals. The manual focuses largely on mice, but also contains protocols for successful transgenesis in rats, cows, pigs and birds. The manual provides detailed, step-by-step protocols covering all aspects of the production of transgenic animals, including the use of lentiviral vectors in gene transfer, intracytoplasmic sperm injection, nuclear transfer, large insert transgenesis, conditional gene expression systems, the use of reporter genes in transgenesis and transgenesis in large animals and birds. The text is supplemented by superb color photos. While the focus is on newly established techniques, the fundamental methods of transgenesis are also covered for those new to the field. Thus this manual is perfectly suited for those wishing to adopt new technologies in transgenesis.

The human body contains many specialized tissues that are capable of fulfilling an incredible variety of functions necessary for our survival. This volume in the Human Cell Culture Series focuses on mesenchymal tissues and cells. The in vitro study of mesenchymal cells is perhaps the oldest form of human cell culture, beginning with the culturing of fibroblasts. Fibroblasts have long been generically described in the literature, arising from many tissue types upon in vitro cell culture. However, recent studies, many enabled by new molecular biology techniques, have shown considerable diversity in fibroblast type and function, as described within this volume. Mesenchymal tissue types that are described within include bone, cartilage, tendons and ligaments, muscle, adipose tissue, and skin (dermis). The proper function of these tissues is predominantly dependent upon the proper proliferation, differentiation, and function of the mesenchymal cells which make up the tissue. Recent advancements in primary human mesenchymal cell culture have led to remarkable progress in the study of these tissues. Landmark experiments have now demonstrated a stem cell basis for many of these tissues, and, furthermore, significant plasticity and inter-conversion of stem cells between these tissues, resulting in a great deal of contemporary excitement and controversy. Newly-developed mesenchymal cell culture techniques have even lead to novel clinical practices for the treatment of disease.

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.