Immunologi

The full inside story of the high-stakes, global race for the lifesaving vaccine to end the pandemic Heroic science. Chaotic politics. Billionaire entrepreneurs. Award-winning journalist Brendan Borrell brings the defining story of our times alive through compulsively readable, first-time reporting on the players leading the fight against a vicious virus. The First Shots, soon to be the subject of an HBO limited series with superstar director and producer Adam McKay (Succession, Vice, The Big Short), draws on exclusive, high-level access to weave together the intense vaccine-race conflicts among hard-driving, heroic scientists and the epic rivalries among Washington power players that shaped 18 months of fear, resolve, and triumph. From infectious disease expert Michael Callahan, an American doctor secretly on the ground in Wuhan in January 2020 to gauge the terrifying ravages of Disease X; to Robert (Dr. Bob) Kadlec, one of Operation Warp Speed's architects, whose audacious plans for the American people run straight into the buzz saw of the Trump White House factions; to Stéphane Bancel of upstart Moderna Therapeutics going toe-to-toe with pharma behemoth Pfizer, The First Shots lays bare, in a way we have not seen, the full stunning story behind the medical science "moon shot" of our lifetimes.

Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a continuous and dynamic way. In 8 chapters, Microbial Crosstalk with Immune System: New Insights in Therapeutics provides an overall introduction with special focus on how the immune system which is specifically geared to get rid of non-self-antigens, allows numerous microbes to colonize the human body. In the presence of microbes there are several observations that suggest that there are multiple roles that are played by these microbes in tumor progression and shaping of our immune system which is explained at length in subsequent chapters. Microbial Crosstalk with Immune System: New Insights in Therapeutics discusses the emerging mechanisms of immune-therapeutics as well as its limitations while emphasizing the potential role of microbes in shaping immune-therapeutic and evolving novel strategies to deal with any limitations.

An unbiased, neutral, fact-based investigation that simply allows the science to do the talking on childhood vaccinations. Written by father and son investigative journalism/research team Lance & James Morcan, with a foreword by medical laboratory scientist Elísabet Norris, VACCINE SCIENCE REVISITED is possibly the most well-referenced work yet to explore this contentious healthcare subject.This exhaustively-researched book avoids all rumor, conjecture and anecdotal evidence, and steadfastly focuses on what the latest medical studies actually reveal about vaccines listed on the immunization schedule. One by one the ingredients of the vaccines being manufactured today are put under the microscope by comparing peer-reviewed, published studies.By collaborating with a professional medical advisory team and utilizing investigative journalism methods, the Morcans have painstakingly sifted through the world's best scientific research papers. They analyze the most reliable and untainted studies in order to uncover true and accurate data on vaccine safety.No matter your level of education or experience - whether you are a doctor, layman, scientist, nurse, med student or new parent - be prepared to be surprised by many of the medical research findings in VACCINE SCIENCE REVISITED: Are Childhood Immunizations As Safe As Claimed?

Illness is a part of life. For many years we have known about disease. But we were not always so smart. The Black Plague ravaged Europe between 1347-1352 and killed 30-80 MILLION people. No one knew how people caught the condition and lots of ideas failed-people just died. But not everyone died; possibly their immune systems help them fight off these "invaders".Today we know about bacteria, viruses, cancers and other invaders and we usually let them run their course. That is because our bodies detect and fight them. That is immunity.

Kompendium i Immunologi omfatter og illustrerer de fundamentale koncepter i basal og klinisk immunologi. Kompendiet er rettet mod studerende på de sundhedsvidenskabelige uddannelser, herunder medicinstuderende, veterinærstuderende, farmacistuderende og odontologistuderende. For at overskueliggøre faget og dermed optimere læringsprocessen for de studerende er der i kompendiet anvendt skematiske figurer, flowcharts, tabeller samt farvekoder. De basale afsnit introducerer det innate og det adaptive immunsystem, immunceller, antistoffer og antigener samt andre komponenter i immunsystemet og deres respektive interaktioner. De kliniske afsnit dækker overfølsomhedsreaktioner, transplantationer, cancer og vaccinationer.

In How to Make Disease Disappear, Dr. Rangan Chatterjee presents a radically simple plan for taking control of your health and your life.Chronic diseases such as type 2 diabetes, high blood pressure, depression and dementia are today the nation's leading causes of death and disability. Half of all American adults currently suffer with a chronic disease, with one in four people suffering from two or more. Despite the statistics, so much confusion exists about what we can do to protect ourselves and live long, healthy lives.Acclaimed functional medicine doctor Rangan Chatterjee writes, ?The good news is that I can make these diseases disappear. That's right. This probably sounds like an extraordinary claim, but the reason I can make them disappear is that they're an illusion. These diseases are not the inevitable result of aging. They are not simply our genetic fate or our destiny. We do not have to suffer needlessly. The truth is these diseases don't really exist, at least not in the way we think they do.?A life free of disease revolves around Dr. Chatterjee's four pillars: relaxation, food, sleep and movement. By making small, achievable changes in each of these key areas, you can create and maintain good health?and, most importantly, avoid and reverse illness.Based on cutting-edge research and fascinating case studies from real patients, How to Make Disease Disappear is a practical and revolutionary path to avoiding disease and embracing the health we all deserve.

Frontiers in Clinical Drug Research - Anti-Allergy Agents is a book series comprising of a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs.The third volume of this series brings 5 reviews which cover the following topics: H1 receptor selectivity, chronic spontaneous urticaria therapy, smooth muscle cell Ca2+ signaling pathway targeting for asthma therapy, allergic rhinitis and endosomal toll-like receptors. Frontiers in Clinical Drug Research - Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.

In this essential book on gluten, Dr. Peter H. R. Green, internationally renowned expert on celiac disease and director of the Celiac Disease Center at Columbia University, and acclaimed medical writer Rory Jones reveal the real scientific story behind the current gluten-free craze, identifying what is true and what is just pseudoscience.In recent years, gluten has become a villain, getting blamed for anything and everything from heart disease and dementia to neuralgia and fatigue. Droves of people are adopting a gluten-free lifestyle, believing it's healthier or that it will help them lose weight and increase their energy. The diet, a regimen once followed only by those diagnosed with celiac disease (a serious autoimmune disorder caused by gluten), has become a cure-all, ?prescribed? not only by gastroenterologists but also by dietitians, nutritionists, naturopaths, trainers, psychiatrists, and neurologists, as well as by celebrities and media personalities. Yet as Gluten Exposed reveals, there is little scientific evidence to justify this trend. The latest medical findings have shown that the majority of the information available about the effects of gluten on the body is only partly correct, or almost wholly incorrect. Green and Jones, authors of Celiac Disease: A Hidden Epidemic, cut through the misinformation, false claims, and widespread confusion over gluten. They examine the connections between the gut, brain, and what you ingest (not just gluten, but other food and drugs) to reveal what's really going on in your body and your brain. They also bring to light the potential dangers of going gluten-free. While the diet is a lifesaver for those with celiac disease, for others it may injure health, rob the body of essential nutrients, and mask real problems. In fact, one of the biggest risks of going on a gluten-free diet without properly testing for what is causing your symptoms is postponing or missing a potentially serious diagnosis.Gluten Exposed provides an in-depth examination of every symptom and condition associated with gluten, how gluten works in the body, what a gluten-free diet cures?and what it doesn't?and which drugs, supplements, and foods can cause problems often blamed on gluten alone. It offers clear, welcome guidance and a practical road map that can help anyone achieve a healthier, symptom-free life.

This new volume in the series Emerging Infectious Diseases of the 21st Century is a novel book on the role of microbes in the pathogenesis of common and disabling non-infectious diseases. New insights have emerged over the past several years suggesting that our commensal microflora of the gut is extremely important in regulating physiological and immune functions of the body. Covered are the perturbations of the normal composition of our endogenous microbiota, influenced by diet and genetic predispositions, as well as the mechanisms to produce common disorders such as obesity, diabetes, irritable bowel syndrome, colon cancer and atherosclerotic vascular diseases. Also explored is the evidence suggesting that predisposition to increasingly common afflictions such as asthma and multiple sclerosis is influenced, in combination with our genetic composition, by early life exposure to environmental microbes and the time of onset of common viral infections. Chapters provide the most recent information on these disorders with regards to epidemiology, current concepts on pathogenesis and mechanisms of their biology, recent research and data on the role of microbes, analysis of their validity and conclusive remarks and areas for future research.The Role of Microbes in Common Non-Infectious Diseases is an excellent resource for both physicians and investigators from a broad range of disciplines that will help to stimulate new concepts of disease pathogenesis and lead to the unraveling of their mechanisms of diseases and to novel treatments.

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity currently provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulates the hosts immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host. From the early stages of binding and receptors-mediated signalling, to new paradigms by which heat shock proteins are released into the circulation, to antigen processing and presentation, and finally to the immune response itself this book is a must read for graduate and postgraduates in the field of Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

"Berzin draws on cutting-edge research and her work with thousands of patients to tell the complete story of how our bodies drive our minds, mood, and energy levels. She explains how the new science will optimize the body in ways that will help anyone attain a new baseline for energy, calm, and optimism. Treating common imbalances in the body is the only way to achieve what she calls a state change: a transformation to higher levels of mental focus, emotional stability, and flow. Her book includes a 30-day program for resetting the body, mind, and mood."--

We live in a world that is sick. Both literally sick, with chronic illness on the rise, and figuratively sick, facing ever increasing rates of burnout, disconnection, and disaster. Lyndsey Medford draws on her experience living with a rare autoimmune disease to offer the broader lessons we need to heal what ails us, individually and communally.

The present novel is a Science Fiction one. But, in addition to its SF genre, it also contains a lot of data on the dangerous viruses of the world, including that of the Coronavirus. It summarizes their histories, life cycles, and their clinical impact. It is also an easy virological guide for laymen - a "light" textbook that might interest people who do not intend to peruse Virological textbooks in medical libraries. Therefore, pay a few dollars for the book, sit in your favorite armchair, read the Science Fiction story, and concurrently, become knowledgeable on the fascinating and the oh so dangerous viruses of our planet.

Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths.This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment.Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students.

This new edition explores lab protocols describing new techniques to study cytotoxic T-cells (CTLs), as well as chapters of a more general discursive nature, all with an emphasis on the use of systems biology in immunology. Beginning with phenotypical characterization of CTL populations, the volume continues with in vitro and in vivo cytotoxicity assays, methods to detect senescent T cells, in vivo and in vitro models to understand immune and bone cells cross-talk, microscopy and in vivo imaging, as well as ¿Omics¿ approaches and molecular methods, concluding with chapters on CTL involvement in transplantation and link microbiota-immunity. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detail and key implementation advice for best results in the lab. Authoritative and up-to-date, Cytotoxic T-Cells: Methods and Protocols, Second Edition serves as an ideal guidefor researchers working with these vital cells.

This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical rodent models of sepsis, presented by experts in the field. In addition, the book includes protocols for burn injury and sepsis, modeling the mouse intensive care unit (MICU), and the development of humanized mice, which may be useful tools to increase the translational potential of rodent sepsis research. There is a chapter discussing the use of biomarkers for sepsis diagnosis and prognosis in humans and mice, as well as chapters describing specific methods for biomarker measurement, and the use of analgesics and humane endpoints in rodent sepsis research. Finally, agent-based computational modeling is presented as a valuable complementary approach to study sepsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Sepsis: Methods and Protocols serves as an ideal guide for researchers working toward improving the identification and treatment of septic patients.