Medicinsk mikrobiologi og virologi

Hvordan forårsager mikroorganismer sygdomme som fødevareforgiftning, ebola, borreliose og rævebændelorm? Og hvordan udnyttes andre mikroorganismer som Saccharomyces, E. coli og probiotiske bakterier i madlavning, i produktion af øl og i kroppens tarmsystem?Mikrobiologi giver en god forståelse af de forskellige mikroorganismer, deres vækst, deres funktioner samt deres rolle i fødevareproduktion. Bogens første del indeholder en grundig gennemgang af den moderne systema- tiske bakteriologi, og derudover beskrives virus, svampe, protozoer og parasitter. Anden del af bogen giver en grundig indføring i fødevarernes produktion, mikro- biologiske risici samt konserveringsmetoder, og hvordan man kan arbejde med fødevaresikkerhed, så mikroorganismerne ikke udgør en sundhedsrisiko.Bogens målgrupper er studerende ved korte og mellemlange videregående uddannelser på det sundhedsfaglige, fødevareteknologiske, laboratorietekniske og procesteknologiske område samt mindre produktioner/virksomheder, der arbejder med mikrobiologi. Bogen kan også anvendes til temaundervisning i fx biologi eller bioteknologi i gymnasiet. Desuden kan den benyttes som opslagsværk for særligt mikrobiologiinteresserede. Endelig kan mindre fødevarevirksomheder have gavn af kapitlerne om hygiejne, egenkontrol og fødevaresikkerhed.Denne 5. udgave er ajourført og grundigt revideret. Der er blandt andet tilføjet afsnit om biofilm og tarmbakterier. Desuden er kapitlerne om fødevaresikkerhed blevet udvidet, således at de kan bruges som opslagsværk af fødevarevirksom- heder. Endelig er bogen blevet opdateret med et helt nyt layout.

Virus har sat dagsordenen i Jens Lundgrens arbejdsliv, lige siden han som helt ung læge stod ved sygesengen hos dødsmærkede aidspatienter og forskede i at finde en effektiv medicinsk mehandling til dem. Resultatet kan alverdens hiv-patienter takke ham for i dag.Siden coronapandemiens start har han knoklet for at hjælpe livstruede patienter og udvikle nye behandlinger med videnskabeligt dokumenteret effekt. Han har rådgivet de danske sundhedsmyndigheder og regeringen, og han har arbejdet tæt sammen med toppen af det amerikanske sundhedsvæsen under pandemigeneralen Anthony Fauci.I Vild virus giver han et unikt indblik i, hvad der sker bag kulisserne, når en virus truer os på livet og vender op og ned på vores hverdag. Bogen giver den første samlede beretning om de to vilde pandemiår: forskernes kapløb med tiden og en virus, der er en mester i at mutere, håndteringen af alle de udfordringer, virus pludselig kastede os ud i – og hvad vi har lært, så vi kan være bedre forberedte, når den næste virus udfordrer vores eksistens. For det vil ske: Pandemiernes tid er langtfra forbi.Bogen er blevet til i tæt samarbejde med Lars Igum Rasmussen, der som sundhedsredaktør på Politiken har dækket coronapandemien med mere end 200 nyhedsartikler, interviews, reportager og analyser.

'Thrilling and eye-opening' Lewis Dartnell'Unpicks everything we thought we knew... Mind blowing' Cal Flyn'A revelation' Sathnam SangheraHumans did not make history - we played host.According to the accepted narrative of progress, a few great humans have bent the arc of history. But in this revelatory book, Dr Jonathan Kennedy argues that germs have done more to shape humanity at every stage, from the first success of Homo sapiens over the equally intelligent Neanderthals to the fall of Rome and the rise of Islam.How did an Indonesian volcano help cause the Black Death, setting Europe on the road to capitalism? How could 168 men extract the largest ransom in history from an opposing army of eighty thousand? And why did the Industrial Revolution lead to the birth of the modern welfare state?The latest science reveals that infectious diseases are not just something that happens to us, but a fundamental part of who we are. Indeed, the only reason humans don't lay eggs is that a virus long ago inserted itself into our DNA, and there are as many bacteria in your body as there are human cells. We have been thinking about the survival of the fittest all wrong: evolution is not simply about human strength and intelligence, but about how we live and thrive in a world dominated by microbes.By exploring the startling intimacy of our relationship with infectious diseases, Kennedy shows how they have been responsible for some of the seismic revolutions of the past 50,000 years. Provocative and brimming with insight, Pathogenesis transforms our understanding of the human story, revealing how the crisis of a pandemic can offer vital opportunities for change.

Mikrobiologikortene hjælper dig med at huske information om de forskellige pensumrelevante humanpatogene mikroorganismer, når du skal læse til eksamen i mikrobiologi på medicinstudiet. Der er 163 kort, som du kan repetere alene eller med en læsemakker. Hver mikroorganisme er repræsenteret ved et kort, som i kondenseret form oplyser om karakteristika, infektioner, forekomst, smitteveje, diagnostik og forslag til behandling. Der medfølger desuden grendiagram-oversigter over de forskellige bakterier, virus, svampe og parasitter.

Resistente bakterier er blevet en større trussel langt hurtigere, end eksperterne hidtil har forudset det. Studier peger på, at resistente bakterier i 2050 vil tage livet af lige så mange mennesker som for eksempel kræftsygdomme.Da Alexander Fleming i 1928 opdagede antibiotika, revolutionerede det lægevidenskaben. Her små hundrede år efter er vi ved at sætte hele fremskridtet over styr. Ifølge professor i mikrobiologi Hans Jørn Kolmos er det nødvendigt med en anden tilgang til udviklingen og ikke mindst brugen af antibiotika i sundhedsvæsenet og landbruget, hvis vi i fremtiden vil undgå, at helt almindelige infektioner kan blive livstruende.Hans Jørn Kolmos (f. 1948) er professor på Syddansk Universitet og tidligere overlæge på Klinisk Mikrobiologisk Afdeling på Odense Universitetshospital, hvor han blandt andet har ledet forskningen i MRSA. Kolmos er vokset op på en stor gård ved Toftlund i Sønderjylland, og slægten har drevet landbrug i flere hundrede år.Moderne Ideer er støttet af Lundbeckfonden, Augustinus Fonden og Statens Kunstfond. I bøgerne gør førerende forskere deres viden tilgængelig og leverer deres bud på, hvordan vi løser tidens største udfordringer.

This book focuses on the important discoveries of the small molecule-, peptide-, and protein-based virus entry inhibitors and discusses advance of the development of different type of virus entry inhibitors as a novel class of antiviral drugs for treatment and prevention of viral infection. It includes entry inhibitors of HIV,HeV, NiV, RSV, EBOV, HCoV, HBV, HCV, HDV, HPV, flavivirus and influenza virus, so on. This book aims at providing an updated knowledge on virus entry inhibitors.

This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis. The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.

This book presents a comprehensive view on mycotoxins of agricultural as well as non-agricultural environments and their health effects in humans and animals. Mycotoxins have immunosuppressive effects; but some of them can cause cancers, mutagenicity, neurotoxicity, liver and kidney damage, birth defects, DNA damage and respiratory disorders. The problem of mycotoxins is long-lasting and their direct or indirect exposures to humans and animals must be further discussed. The first chapter will cover the historical perspective of mycotoxins along with timeline while the second one will provide overview including classification of mycotoxins and mycotoxicoses. The comprehensive information/ literature on traditional, emerging and mushroom mycotoxins will be given in chapters 3, 4 and 5 respectively. Chapter 6 will deal with mycotoxins co-occurrence poisoning whereas new and masked mycotoxins will be described in chapter 7. The important aspects of mycotoxin studies like extraction, characterization and analysis and management strategies will be summarized in 8 and 9 chapters. The last chapter of the book will cover the recent developments in toxicokinetic studies of mycotoxins. The book will have the most up-to-date information and recent discoveries to deliver accurate data and to illustrate essential points to a wide range of readers including mycologists, clinicians, agricultural scientists, chemists, veterinarians, environmentalists and food scientists.

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates.The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.

This book presents a comprehensive collection of current knowledge and leading research about the blood-brain barrier. The chapters are organized in four main parts providing basic information and novel insights about the physiology of the blood-brain barrier, the challenges related to finding and developing drugs crossing the blood-brain barrier, experimental methods to study the blood-brain barrier and the role of the blood-brain barrier in disease mechanisms and its consequences for drug development. In the first part the readers will discover the structure, function and developmental aspects of the blood-brain barrier and gain novel insights into the complexity and functionality of the neurovascular unit and energy metabolism of brain endothelial cells. Chapters of the second part focus on translational challenges from the bench to the bedside in CNS drug development, shed light on the importance to understand the brain distribution of drugs related to their efficacy, elaborate on general pharmacokinetic considerations for CNS drugs and introduce current and novel drug delivery strategies to overcome the blood-brain barrier. The experimental part of the book covers mathematical and in vitro models as well as animal and human methods in blood-brain barrier research. Specific emphasis is set on the description of the methods, the role of species differences for data interpretation, novel human models based on stem cells with the potential for personalized medicine and technical considerations and tips helpful for readers interested in working with these models. In the fourth part particular attentions is given to the blood-brain barrier, its changes and participation during disease progression. Chapters summarize alterations of the blood-brain barrier that are present in common disorders such as Alzheimer's disease, multiple sclerosis, stroke, traumatic brain injury, epilepsy and brain tumors. Present therapies will be discussed and the consequences for novel treatment approaches that need to bypass the blood-brain-barrier will be explored. In addition, experts discuss the question in how far changes at the blood-brain barrier are causally linked to disease progressions and consequently could serve as therapeutic targets. This collection is designed to appeal to a wide readership from students through basic and applied scientist to pharmacologists, medical doctors and stakeholders from the pharmaceutical industry and regulatory affairs. Due its comprehensive content the book has the potential to become a standard work in the field of blood-brain barrier research.

This volume discusses hazardous environmental micropollutants, their impacts on human health, and possible means to mitigate their associated risks. The book features chapters that cover a variety of topics related to environmental micropollutants, which include dusts, infectious particles, heavy metals, organophosphates, atmospheric toxic organic micropollutants, fungal spores, pollutants from E-waste, antibiotic waste, and more. In addition impacts on human health and the environment, economic issues are addressed, with potential policy solutions offered. This work is timely, as hazardous micropollutants in soil, water and air are becoming more common, and this environmental contamination is leading to increasing instances of suboptimal human health outcomes. The book will be of interest to students and researchers in environmental pollution and remediation technology, microbiologists, and environmental regulators.  

This book provides an up-to-date overview on the biology of microsporidia, focusing on areas where significant progress has been made in recent years. In particular, our understanding of the evolutionary position and the role of genome reduction in the biology of these enigmatic intracellular pathogens is discussed. This book also offers important updates on the mechanisms used by these organisms to modify the host cell biology of mammals, insects, nematodes, and aquatic animals, as well as the mechanisms controlling infection and host specificity. Readers gain a detailed overview of the structure and function of the polar tube, the unique invasion apparatus of microsporidia, as well as the physics and dynamics of spore firing. Particular attention is given to chronic infections in mammals caused by microsporidia, as well as common immune responses.Written by an international team of authors representing the main research groups working on microsporidian biology, this book is a valuable resource for health management professionals, experienced microbiologists, and early career scientist alike who want to learn more about these fascinating parasites. The ideas and latest finding covered in this book contribute to UN Sustainable Development Goal 3: Good Health and Well-Being.  Chapter "e;Impact of Genome Reduction in Microsporidia"e; is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book provides a comprehensive analysis of microbial polysaccharides, their current uses, and highlights biomedical opportunities. The topics comprise principally a) their extraction, isolation, purification and advanced production processes; b) characterization of their structural, physicochemical, and biological properties, among others, by several techniques; c) description of the advanced functionalization and modification methods for the polysaccharide based-material; and d) their applications and uses in medical and pharmaceutical fields. Each chapter is written by world-renowned academics and practitioners on their field.This is an essential reference for students in biomedical, chemical, material, and microbiology engineering as well as researchers and professionals in the medical field.

Contrary to common belief, infectious diseases are not as well under control as we would like. We are now at a crossroads regarding the impact of the environment on infectious diseases. Renewed interest in biological weapons and the emergence of new pathogens, coupled with a better understanding of the impact of infectious agents on other conventional diseases, has led us to realise that we can no longer remain complacent about the impact of infectious agents on human, animal and crop health. The present book first discusses current and emerging military and civilian policies on the environment. In addition, the impact of environmental biology on the future of space exploration is discussed, especially in reference to the Mars mission. There follows a discussion of the state of bacteria in the environment, with a presentation of current and emerging techniques of microbial investigation. Finally, two case studies are presented on the impact of these techniques on both political and environmental problems.