Sandsynlighedsregning og statistik

This book not only presents an essential material to understand fuzzy metric fixed point theory but also enables the readers to appreciate the recent advancements made in this direction. It contains seven chapters on different topics in fuzzy metric fixed point theory.

Methodologies for Biosimilar Product Development covers the practical and challenging issues that are commonly encountered during the development, review, and approval of a proposed biosimilar product. These practical and challenging issues include, but are not limited to the mix-up use of interval hypotheses testing (i.e., the use of TOST) and confidence interval approach, a risk/benefit assessment for non-inferiority/similarity margin, PK/PD bridging studies with multiple references, the detection of possible reference product change over time, design and analysis of biosimilar switching studies, the assessment of sensitivity index for assessment of extrapolation across indications without collecting data from those indications not under study, and the feasibility and validation of non-medical switch post-approval.Key Features:Reviews withdrawn draft guidance on analytical similarity assessment.Evaluates various methods for analytical similarity evaluation based on FDA's current guidelines.Provides a general approach for the use of n-of-1 trial design for assessment of interchangeability.Discusses the feasibility and validity of the non-medical switch studies.Provides innovative thinking for detection of possible reference product change over time.This book embraces innovative thinking of design and analysis for biosimilar studies, which are required for review and approval of biosimilar regulatory submissions.

The text introduces students to numerous methods in solving a variety of Optimization problems. Also, the narrow focus of most math textbooks is completely dedicated to nonlinear programming, linear programming, combinatorial or convex optimization.

A recent study found that most business leaders believe in the value of using data and analytics, but say they lack confidence in measures of their effectiveness. In the data analytics community, intuition has been rarely discussed in executive decision-making. The book examines how well do executives trust their intuition.

A recent study found that most business leaders believe in the value of using data and analytics, but say they lack confidence in measures of their effectiveness. In the data analytics community, intuition has been rarely discussed in executive decision-making. The book examines how well do executives trust their intuition.

This book starts with an assumption that actors are controlled by diverse, inconsistent forces and shows that introducing this level of complexity allows for the creation of a wide array of critical game theory models that can help to attain new insights into nature, human nature, human institutions, and human behaviour.

This book casts a new light on Bertrand's Paradox, giving original analyses of the paradox, its possible solutions, the source of the paradox, the philosophical errors we make in attempting to solve it and what the paradox proves for the philosophy of probability.

This book covers Big Data, Machine Learning, and Artificial Intelligences related technologies and how these technologies can enable design, development, and delivery of customer-focused financial services to both corporate and retail customers and how to extend the benefits to the financially excluded sections of society.

This book presents contemporary issues and challenges in finance and risk management in a time of rapid transformation due to technological advancements. It includes research articles based on financial and economic data and intends to cover the emerging role of analytics in financial management, asset management, and risk management.

This book constitutes a selection of the best papers from the 15th International Conference on Business Excellence, Digital Economy and New Value Creation, ICBE 2021, held in Bucharest, Romania, in March 2021.This book is a collection of research findings and perspectives related to the digital economy and new value creation, led by the set of improvements and changes in the economic, societal and technological structures and processes towards the effort of reaching the sustainability goals.

I began this book with the express purpose of making it the definitive comparison of Secretariat and Man o' War. I feel that I've succeeded. By engaging the discipline of applied statistics to compare the legendary achievements of these two horses, I am being completely honest about my two primary audiences-the serious Thoroughbred racing fan and those desiring a clearer comparison of runner quality that only the lens of basic statistics can provide.The statistics in this book are basic and are completely explained as the text progresses. They are not difficult-provided one is motivated to compare Thoroughbreds on an objective rather than subjective level and to spend a modicum of extra time learning the minimal eight-grade-level computations the statistics require.I personally wish all readers well on their journey into what is possibly a groundbreaking area, thereby showing their willingness to accept a very modest challenge.

Questo libro offre una visione dettagliata della storia degli ebrei in Europa dal 1789 al 1870. Attraverso l'analisi di fonti originali e di immagini storiche, il lettore scoprirà l'evoluzione della cultura ebraica in Europa, e la sua relazione con la cultura gentile. Questo libro rappresenta un'importante fonte per chi desidera conoscere la storia degli ebrei in Europa.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

This book provides new theoretic and applied material with focus on quantitative methods and data analysis techniques applied in demography, population studies, health issues and statistics. It discusses the quantitative techniques to estimate the healthy life expectancy by expanding the classical life tables to include the proportion with disability calculated from life tables, along with the Sullivan method. The provided templates apply immediately to the life tables from WHO, HMD, Eurostat and other life table providers. Furthermore, the book explores the possibility of creating new health indicators along with Covid-19 pandemic management, factors associated to loneliness and an alcohol indicator. Part of the book is devoted to mortality, epidemic models, and the supercentenarians age estimation. Data analysis and artificial intelligence methods are included to apply in demographic and socio-economic cases. By providing a methodology to cope with health problems in demography and society by quantifying important health parameters, this book is a valuable guide for researchers, theoreticians, and practitioners from various disciplines and especially health scientists, statisticians, economists, and sociologists.