Neurovidenskab

This comprehensive open access book enables readers to discover the essential techniques for load forecasting in electricity networks, particularly for active distribution networks.From statistical methods to deep learning and probabilistic approaches, the book covers a wide range of techniques and includes real-world applications and a worked examples using actual electricity data (including an example implemented through shared code). Advanced topics for further research are also included, as well as a detailed appendix on where to find data and additional reading. As the smart grid and low carbon economy continue to evolve, the proper development of forecasting methods is vital. This book is a must-read for students, industry professionals, and anyone interested in forecasting for smart control applications, demand-side response, energy markets, and renewable utilization.

In this volume the authors explore the landscape of thought on the ethical and policy implications of Brain Computer Interface (BCI) technology. BCI technology is a promising and rapidly advancing research area. Recent developments in the technology, based on animal and human studies, allow for the restoration and potential augmentation of faculties of perception and physical movement, and even the transfer of information between brains. Brain activity can be interpreted through both invasive and non-invasive monitoring devices, allowing for novel, therapeutic solutions for individuals with disabilities and for other non-medical applications. However, a number of ethical and policy issues have been identified from the use of BCI technology, with the potential for near-future advancements in the technology to raise unique new ethical and policy questions that society has never grappled with before. The volume has three parts: 1) Past, Present and Future of BCI technology, 2) Ethical and Philosophical Issues and 3) Legal and Policy Implications. The rich and detailed picture of the field of BCI ethics with contributors from various fields and backgrounds, from academia and from the commercial sphere may serve as an introductory textbook into the neuroethics of BCI, or as a resource for neuroscientists, engineers, and medical practitioners to gain additional insight into the ethical and policy implications of their work.

This volume provides a detailed update on progress in the field of hair cell regeneration. This topic is of considerable interest to academicians, clinicians, and commercial entities, including students of auditory and vestibular neuroscience, audiologists, otologists, and industry, all of whom may have interest in hair cell regeneration as a potential future therapy for hearing and balance dysfunction. In 2008, Springer published a SHAR volume on this subject (Hair Cell Regeneration, Repair, and Protection, Editors Richard Salvi and Richard Fay). Since that time, there has been considerable advancement in this field.This book provides a historical perspective on the field, but the emphasis is on more "prospective" views of the various facets of regeneration research, in the hope that the volume will stimulate new projects and approaches, focusing on the limitations of current knowledge and describing promising strategies for future work. The book will include thefollowing key features of hair cell regeneration:¿ Cellular and molecular control hair cell regeneration in non-mammalian species (in particular zebrafish and chickens) ¿ Our current understanding of the capacity for hair cell replacement in mammals (rodents and humans). ¿ Signals controlling pro-regenerative behaviors in supporting cells, the hair cell progenitors. ¿ New techniques that have been applied to study the genetic and epigenetic regulation of hair cell regeneration in mammals and non-mammals. ¿ Contributions of stem cells toward building new tools to explore how hair cell regeneration is controlled and toward developing cells and tissue for therapeutic transplantation. ¿ Studies that have applied gene and drug therapy to promote regeneration in mammals.

The concept of the ¿Soundscapes¿ includes all of the sounds in one¿s environment and focuses not only on the sounds itself. Instead, it focuses on the interrelationships between person and activity and place, both in space and time. Soundscape also include influences on the acoustic environment through auditory sensation, its interpretation, and the responses to the acoustic environment in context. The conceptual framework of Soundscape describes the ¿process of perceiving or experiencing and/or understanding an acoustic environment, highlighting general concepts and their relationships: context, sound sources, acoustic environment, auditory sensation, interpretation of auditory sensation, responses, and outcomes¿ (International Organization for Standardization, ISO 12913-1:2014 Acoustics Soundscape Part Definition and Conceptual Framework, ISO, Geneva, 2014).With soundscape, one achieves a deeper understanding of acoustic environment and its effects on people. The ISOstandard 12931-1 on soundscape provides an important, and rigorous, distinction in the use of ¿Soundscape.¿ But, it is recognizable that some individuals, particularly planners, designers, lay persons, and even those primarily interested in management of the acoustic environment through environmental noise control, will find it convenient to use ¿Soundscape¿ as a synonym for the physical acoustic environment.When it comes to noise management and urban planning, soundscape research has the potential to promote healthy urban environments by sharing and incorporating the significant knowledge of all concerned parties. Understandably, this shows that the communication with regard to noise management has to be forced to guarantee that the specifics of Soundscapes (i.e., the relevance of perception) are seriously considered alongside the whole.This book will bridge the gap between soundscape theory and practice and therefore it will be different from our earlierpublications as ¿Soundscape and the built environment¿ (ed. by J. Kang and B. Schulte-Fortkamp CRC Press, Taylor and Francis Group, Boca Raton, Fl 2016) and also from the respective Special Issues on Soundscapes in 2012 in The Journal of the Acoustical Society of America (ed. by B. Schulte-Fortkamp and J. Kang), and also the Special Issue in Acta Acustica 2006 *(ed. by B. Schulte-Fortkamp and D. Dubois), and the E-book on soundscape This volume will be driven by the difficult process of standardization of Soundscape and its evaluation procedures. The main goal of the proposed volume is to present and review the developments in Soundscape, reflecting the standardization procedure and the diverse inputs. the needs in management and planning in urban acoustic environments, the book will also focus on the difficulties, as well as the solutions, in interdisciplinary grounded communication, that is, on the one hand, related to science, but on the other to application, that needs guidance.

The present work corresponds to a compilation of independent contributions in the fields of endocrinology, immunity, cancer, neurobiology, and myology. Revision of current advances as well as novel findings in the form of original articles are presented in a balanced fashion. The book has been divided into three sections in line with the main subject: Molecular pathology of immune, inflammatory, and hemostatic disorders; Molecular pathology of endocrine and muscular disorders; and Molecular pathology of cancer: determinants and potential therapies. In the first section, contributing authors take the reader through the molecular pathology of immune responses, inflammation, and hemostasis, by collating an update on systemic autoimmune diseases, the therapeutic potential of statins in hemostasis, the effects of adrenergic stimulation on coagulation, the emerging field of physical burnout due to the mobility restrictions in response to the 2020 SARS-CoV-2 pandemic imposed worldwide, and the success of community-oriented muscular kinesic rehabilitation. The second section presents engaging results from a survey of iodine intake through the diet of pregnant females, an appraisal of the neuroprotective effect of dexmedetomidine, novel evidence on muscle physiopathology, describing the upregulation of CCL5/RANTES during cholestatic liver disease, the fibrotic response emerging in response to cholic and deoxycholic acids, and the altering effects of bile acids in autophagy and mitogenesis. In the third section, a comprehensive revision of cancer literature is offered with an emphasis on melanoma, myeloid-derived suppressor cells, microRNA-based diagnostic approaches, and new avenues for cancer immunotherapy. Altogether, these individual contributions offer a comprehensive and up-to-date outlook of the current state in the field of molecular pathology.Chapter 14 is available open access under a CreativeCommons Attribution 4.0 International License via link.springer.com.

We begin life on an inhalation and end life on an exhalation. Every breath in between is a gift: use them wisely. Discover your superpower, attentional intelligence, so that you can live your life well and make each breath count.

This book discusses timely topics in the field of neurophysiology ranging from descriptions of nerve cells and glial cells to neural networks, sensory processing, neuroplasticity, neuropathophysiology, and human behavior. As such, all organizational levels of the nervous system are considered in one or more of the book¿s twelve chapters. The chapters review or present novel findings and provide the reader with an overview of the current state of the art of neurophysiology research. They discuss research advances in different brain regions and experimental models. In addition, the book contributes to the training of current and future neuroscientists and, hopefully, will lead us on the path to curing some of the biggest challenges in human health.

The autonomic nervous system (ANS) is a subsystem of the nervous system that possesses several levels (groups) for receiving, transmitting, generating, and processing information. This book presents a comprehensive overview of the ANS, including chapters on the role of the ANS in a healthy lifestyle, the ANS-stress relationship, general anesthesia and the ANS, signaling pathways, and more.

"Pavlov's work played a vital role in the development of animal learning research. This book examines his influence on the following 50 years of research, providing extensive coverage of key studies and contributors. Intended for graduate students and researchers in behavioural neuroscience, as well as those interested in learning theory"--

This volume looks at the latest methods used to study imaging techniques, metabolic tracing, and deep muscle phenotyping. The chapters in this book cover topics such as imaging skeletal muscle mass using MRI, dual-energy x-ray absorptiometry, CT, and ultrasound; measures of neuromuscular function such as power/strength/force; microscopy and immunohistochemistry; and ex vivo fibre function and isolation. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and thorough, Neuromuscular Assessments of Form and Function is a valuable resource for researchers interested in multiple methods used to study skeletal muscle neurophysiology.

This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development.In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer's Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson's Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence.Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

This volumes presents current methods used in the research of schizophrenia. Chapters guide readers through molecular techniques, in vivo approaches, cell cultures and heterologous expression systems, and even research methods involving human studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Schizophrenia: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

This highly interdisciplinary book, covering more than six fields, from philosophy and sciences all the way up to the humanities and with contributions from eminent authors, addresses the interplay between content and context, reductionism and holism and their meeting point: the notion of emergence. Much of today's science is reductionist (bottom-up); in other words, behaviour on one level is explained by reducing it to components on a lower level. Chemistry is reduced to atoms, ecosystems are explained in terms of DNA and proteins, etc. This approach fails quickly since we can't cannot extrapolate to the properties of atoms solely from Schrodinger's equation, nor figure out protein folding from an amino acid sequence or obtain the phenotype of an organism from its genotype. An alternative approach to this is holism (top-down). Consider an ecosystem or an organism as a whole: seek patterns on the same scale. Model a galaxy not as 400 billion-point masses (stars) but as an object in its own right with its own properties (spiral, elliptic). Or a hurricane as a structured form of moist air and water vapour. Reductionism is largely about content, whereas holistic models are more attuned to context. Reductionism (content) and holism (context) are not opposing philosophies - in fact, they work best in tandem. Join us on a journey to understand the multifaceted dialectic concerning this duo and how they shape the foundations of sciences and humanities, our thoughts and, the very nature of reality itself.

This volume explores the diversity of distributed eyes and other unusual visual systems in nature. It compares the unique themes of optics, neural processing, and behavioral control that emerge from these visual systems with more-canonical eyes. This volume attempts to answer a number of questions about distributed visual systems. What are distributed visual systems good for, how do they function, and why have they arisen independently in so many phyla? Why are eye designs and visual system arrangements much more diverse in invertebrates? Each chapter includes an overview of the visual systems that exist in their group of animals, relates vision to ecology, and takes a comparative approach.

This detailed volume presents validated and well-adapted procedures involving humanized and/or stem cell-based neural model systems that have proven helpful in better understanding the essential brain functions involved in the pathogenesis of brain disorders. The book explores the generation of multiple neural cell types in 2D and 3D as well as cutting-edge techniques to assay neural function. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell-Based Neural Model Systems for Brain Disorders serves as an essential resource for researchers and students in neuroscience, stem cell biology, and related fields.

Language, as a system we use to communicate, represents the brain¿s biologically perfected machinery for converting thoughts (ideas, concepts, and reflections of both the outside world and our inner feelings) into words and sentences. Crucially, this process occurs in real time. How hundreds of billions of neurons within the dark of the skull control language and speech remains, in some respects, a mystery. To track such neural dynamics in time, we need to exploit physiological tools capable of following temporal patterns of neural activity on a fine-grain time scale. In parallel, it is necessary to begin to provide a real interdisciplinary academic background for scholars wishing to embark on this field of study. Unlike many similar efforts, this book has been conceived as a hands-on tool offering the reader the possibility to progressively acquire principles, techniques, and methods necessary to pursue interdisciplinary research in a fascinating field intersecting linguistic andneuroscience. It focuses on neurophysiological methods and applications useful to track the high speed and rapid temporal dynamics of neural activity involved in language and speech. The chapters in this book are organized into four parts. Part One discusses neural principles and tools for an effective approach to the field of investigation. Part Two looks at the issues and perspectives concerned with the use of a range of neurophysiological technologies to investigate the neural computations of language and speech processes. Part Three focuses on an in-depth exploration of the neural processes associated with the main types of linguistic information, ranging from phonemes and prosody to syntax, pragmatics, and figurative language. Lastly, Part Five explores the phenomena that goes beyond the segments of basic linguistic units. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory Cutting-edge and thorough, Language Electrified: Principles, Methods, and Future Perspectives of Investigation is a valuable resource that offers the necessary tool-box for all researchers and scientists interested in the challenging field of the neurophysiology of language and speech.

This volume covers a wide range of model systems from invertebrate to humans and in vitro and in vivo. Chapters detail methods on squid, aplysia, xenopus, mouse in vivo, ex vivo, rodent primary neurons, human-derived neurons, zebrafish, drosophila in vivo, primary neurons, c. elegans, and in vitro reconstitution assays.Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Axonal Transport: Methods and Protocols aims to further our understanding of the trafficking of cellular components in the nervous system leading to the advancement of basic knowledge that underlines the cell biology of the neuron.The chapters " Live imaging of RNA Transport and Translation in Xenopus Retinal Axons, Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons, Assessment of Mitochondrial Trafficking as A Surrogate of Fast Axonal Transport in Human Induced Pluripotent Stem Cell Derived Spinal Motor Neurons, Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport, and In vitro Reconstitution of Kinesin-Based, Axonal mRNA Transport" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com

There is increasing evidence that mental health problems such as schizophrenia, depression and anxiety are linked with poor nutrition. This is a book for mental health professionals, to enable them to use state of the art nutritional interventions alongside conventional therapies when treating their patients.

The plethora of miscommunication and disinformation about how SARS-CoV-2 (COVID-19) spreads suggests a widespread misunderstanding of how viruses work. This book will focus on the interpretation of scientific and medical results, giving the reader guidance on interpreting virological data, including the concepts of 'live' versus infectious virus.

The study of the brain-mind complex has been hampered by the dichotomy between objective biological neuroscience and subjective psychological science. The two antithetical avenues of research are partly responsible for the failure to unravel the transformation of neural events into mental images: how matter becomes imagination, and vice versa; is the brain¿s consciousness equivalent to Ego consciousness? Is the ego the self? In its new and updated edition, ¿The Rosetta Stone of the Human Mind: Three Languages to Integrate Neurobiology and Psychology¿ illustrates how the simultaneous use of the languages of neurobiology, of mathematics, and of the humanities, enriches the understanding of the neural and mental realms and adds new dimensions to our perception of neuropsychological events. Dr. Sanguineti shows how the two seemingly dichotomous approaches are similar in what they describe, and he explores how the awareness and application of these perspectivesare helpful in getting a deeper theoretical grasp on major mental events, giving us a better understanding of individual minds, and fostering a more integrated therapeutic intervention. The intended readers include neuroscientists, psychiatrists, psychologists, and anyone interested in the human mind.