Biokemi

IMMUNOLGI 2. udgaveImmunologi er fagets autoritative standardværk, og nu foreligger det i denne gennemreviderede 2. udgave.Bogen dækker den basale immunologi og fokuserer på de immunologiske komponenter og mekanismer, der er særligt vigtige for sygdom. Til 2. udgaven er bogen opdateret med 6 nye kapitler, som adresserer immunologien i centrale organer, herunder centralnervesystemet, fordøjelseskanalen, luftvejene og huden, for at afdække og forstå årsag og patogenesen. Desuden er tilføjet kapitler om hukommelse, autoimmunitet og transfusionsimmunologi.Immunologi 2. udgave er fuldt pensumdækkende for faget immunologi ved landets medicinske fakulteter, men er også relevant for andre sundhedsfaglige grupper, såsom tandlæger, dyrlæger og sygeplejersker.Christian Kanstrup Holm er lektor, ph.d., cand.scient på Institut for Biomedicin ved Aarhus Universitet.

Dette kompendium er til dig, der skal bruge en grundig men kortfattet, illustreret og letforståelig gennemgang af menneskets metabolisme og biokemi.Kompendium i Metabolisk biokemi giver en grundlæggende forståelse for menneskekroppens metaboliske processer, pathways, samt regulering af disse. Metabolitter som kulhydrater, lipider, proteiner og nukleotiders optag, omsætning og udskillelse i kroppen, gennemgås trin for trin med illustrative figurer. Foruden de metaboliske pathways, bliver nøje udvalgte beregningsopgaver af alt fra energiforbrug og -udbytte samt regneopgaver med ernæring, enzymaktivitet og iltforbrug gennemgået.Kompendiet er velegnet til farmaci-, odontologi-, medicin- og veterinærstuderende, samt andre med interesse for metabolisme og biokemi.

Biokemi udforsker de kemiske processer i levende organismer på cellulært og molekylært niveau.Dette kompendium giver dig et overblik over det centrale dogme, intracellulær proteinsortering og biokemiske metoder. Forfatterne har ved udarbejdelse af dette kompendium haft fokus på at skabe simple figurer samt letforståelig tekst.Kompendium i Biokemi er primært rettet mod studerende på sundhedsfaglige videregående uddannelser, specielt farmaci-, læge- og veterinærstuderende.

Time is a critical factor in sorting out problems practically. Regarding the quality system as deviations, complaints, and CAPAs, the author had to look up many different sources to find possible answers. Understanding the incident and seeing the issue is crucial in sorting it out and is half of the way. Following the problem diagnosis, the book will guide the user to the possible cause (s). Reaching out to the possible causes, the reader can find the one that fits more to the specified case and see the suggested solution. The author designed the book as simple as possible and preferred avoiding formal reading texts to prevent losing track in sorting the issue. Since the author prepared the present document for many levels' audience, it is suitable for understanding and uses from technician operators to drug formulation designers.

Kompendiet er målrettet medicinstuderende på 5. semester og har til formål at skabe et overblik over de processer i blodet, der er kernepensum i “Kursus i endokrinologi, reproduktion og blod”. Det gælder først og fremmest hæmostasen, transport af ilt og kuldioxid i blodet, erythrocyttens metabolisme og forsvar mod oxidativt stress, omsætning af hæm samt plasmaproteiner generelt – herunder vævsspecifikke enzymer. Der er lagt stor vægt på at formidle stoffet på en pædagogisk og overskuelig måde, og derfor rummer kompendiet mange illustrationer og oversigter. Kompendiet er velegnet som basis for studier i de detaljerede, traditionelle lærebøger. Kompendiets form og indhold er resultatet af forfatterens mange års erfaring med undervisning i kurset.

This volume covers various aspects of affinity chromatography along with examples of its applications. Chapters guide readers through methodologies to purify a diverse array of molecular targets such as antibodies, extracellular vesicles, recombinant proteins, biomarkers, metabolites, plant organelles, nucleic acids, ligand identification and protocols on building affinity matrix. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Affinity Chromatography: Methods and Protocols aims to be an invaluable resource to anyone employing affinity chromatography-based methodologies.

This book comprehensively reviews the proteins associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It also discusses the interactions of the associated-proteins, like bromodomain-containing proteins (BCPs), kinases, synaptic proteins, scaffolding proteins, transcriptional factors, and DNA-binding proteins at the subcellular and molecular levels. The book also explores the potential of these proteins as a druggable target and a biomarker in the neurodevelopmental disorders. The book further explores the recent advancements in understanding the important role of epigenetic factors in predisposition to these diseases. Lastly, it presents genetic factors that lead to variation in gene expression in these diseases, disorders management via diet intervention and the future potential of stem cell therapy.

This proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)'. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation.The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop:· Techniques for biomarker development· Low-dose effect mechanisms· Biomarkers for risk evaluation· Biomarkers in wildlife· Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.

This book is a comprehensive account of recent advances in the endophytic research. It covers recent perspective of endophytic research, molecular diversity, bioprospecting of novel genes using high throughput molecular techniques, and most importantly application of endophytes in practicing sustainable agriculture. Endophytic micro-organisms are mysterious living component associated mutually with plant roots and soil microbes. Various endophytic bacteria have attracted considerable attention for their ability to promote plant growth through direct mechanisms or by acting as biocontrol agents. Endophytes also find use in biocontrol, medicine, agriculture and food industry. This is a useful reading for the student of agriculture, environmental microbiology and biotechnology.

This edited book brings together comprehensive information on various aspects of the biofortification of staple crops. It addresses the present status of food and nutritional security and highlights the importance of micronutrients in human health, a historical account of biofortification, current approaches and challenges, crop-specific biofortification efforts and various breeding approaches, including conventional, and genomics enabled improvement.  It also explains the efficacy of biofortification, bioavailability, and future thrust. It is an inclusive source of information on different aspects of micronutrients in crops of global importance.  Malnutrition is a serious global issue, with millions of people being undernourished, several suffering from micronutrient deficiencies, and the adult population struggling with obesity. Despite significant economic progress, South Asia and Sub-Saharan Africa are still home to an undernourished population. Nutrition-related health problems are related to hidden hunger and are widespread in the developing world. Women and preschool children are more vulnerable. Even though global food production has increased manifolds, estimates indicate that over 60% of the world's population is deficient in essential micronutrients such as iron, zinc, iodine, and selenium, often causing health problems and developmental delays. Linking agricultural production with human nutrition and health is crucial for ensuring nutrition security. Much research has been carried out to assess genetic diversity related to micro-nutrients in staple crops, their bioavailability, and the efficacy of biofortified germplasm. Biofortified varieties developed in different crops through conventional breeding are being up-scaled for reducing the micronutrient deficiencies in other countries.  This book is a ready reference for researchers, academicians, extension personnel, policymakers, students, and value chain stakeholders engaged in agriculture, nutrition, and health sectors promoting nutrition-sensitive diets.

This book illustrates the significance of various optical spectroscopy and microscopy techniques, including absorption spectroscopy, fluorescence spectroscopy, infrared spectroscopy, and Raman spectroscopy for deciphering the nature of biological molecules. The content of this book chiefly focuses on (1) the principle, theory, and instrumentation used in different optical spectroscopy techniques, and (2) the application of these techniques in exploring the nature of different biomolecules (e.g., proteins, nucleic acids, enzymes, and carbohydrates). It emphasizes the structural, conformational and dynamic, and kinetic including the changes in biomolecules under a range of conditions. In closing, the book summarizes recent advances in the field of optical spectroscopic and microscopic techniques.

This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.

Natural compounds obtained from plants represent a tremendous global market due to their use as food additives, cosmetics, in agriculture and in pharmaceuticals. This book provides up-to-date information on various strategies and methods for producing compounds of interest. Leading researchers discuss the latest advances in environmentally friendly natural compound production from plants, making the book a valuable resource for biotechnologists, pharmacists, food technologists and researchers working in the medical and healthcare industries.

This detailed volume explores techniques for researching brown adipose tissue (BAT) and the fascinating biology and therapeutic potential of thermogenic adipocytes. The content reflects the advancing technologies in genetics, imaging, and 'omics strategies that are allowing researchers to probe BAT biology at unprecedented depths and detail, yet it also presents classic physiology principles, which remain the core tenets of BAT biology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Brown Adipose Tissue: Methods and Protocols provides perspectives and detailed protocols for the benefit of both new BAT researchers looking for guidance as well as seasoned researchers who would like to expand their toolkits. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series. For Volume 54, the series editors have invited established chemists to offer cutting-edge reviews of chromatographic methods applied in the life sciences that emphasize the underlying principle of separation science.