Molekylærbiologi

Forensic DNA Applications, Second Edition covers the latest cutting-edge research and advancements in the field and is a must-have reference for established professionals and students entering the fields of genetics and forensic DNA analysis.

Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient.The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics.This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general.The volume comprehensively covers:Emerging technologies for health careVarious aspects of biomedical research toward understanding of pathophysiology of the diseasesAdvances in improvement in diagnostic procedures and therapeutic toolsThe fundamental role of biomedical research in the development of new medicinal products

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.

A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes - the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy

This book brings together leading experts in the field of conservation to provide a comprehensive overview of current best practices, summarise technological advancements, and present a framework for facilitating the integration of reproductive technologies and biobanking into conservation breeding programs for threatened amphibians.

Phenotypic plasticity - the ability of an individual organism to alter its features in direct response to a change in its environment - is ubiquitous. This book brings together researchers who approach plasticity from diverse perspectives to explore new ideas and recent findings about the causes and consequences of plasticity.

Highlights emerging techniques and molecular applications and approaches to address plant abiotic stress, including proteomic approaches, genome editing applications, and system biology approaches. It provides an overview of omics approaches in response to stressors factors at the cellular and molecular levels.

Genomic technologies provide the means of diagnosis and management of many human diseases. Without insights from cytogenetics, correct interpretation of modern high throughput results is difficult, if not impossible.

The book, Bioremediation of Toxic Metal(loid)s, describes the state-of-the-art and potential of emerging technologies on bioremediation of toxic metal(loid)s. It has a compilation of the available comprehensive knowledge of the fundamentals and advancements in the field of bioremediation of toxic metal(loid)s. The mechanisms, applications, and current advancements of various bioremediation strategies used for metal(loid)s have been described in 21 chapters contributed by leading experts from different institutes, universities, and research laboratories from various countries across the globe including Argentina, Canada, Chile, Colombia, France, India, Japan, Republic of Korea, the United Kingdom, and the United States of America. This book offers a bird's eye view on various bioremediation technologies based on a variety of biological agents viz. plants, bacteria, algae, fungi etc., used for environmental clean-up of toxic metal(loid)s.

Analytical pyrolysis allows scientists to use routine laboratory instrumentation for analyzing complex, opaque, or insoluble samples more effectively than other analytical techniques alone. Analytical Pyrolysis Handbook, Third Edition is a practical guide to the application of pyrolysis techniques to various samples and sample types for a diversity of fields including microbiology, forensic science, industrial research, and environmental analysis.The much-anticipated third edition incorporates recent technological advances that increase the technique's sensitivity to trace elements, improve its reproducibility, and expand its applicability. The book reviews the types of instrumentation available to perform pyrolysis and offers guidance for interfacing instruments and integrating other analytical techniques, including gas chromatography and mass spectrometry. Fully updated with new sample pyrograms, figures, references, and real-world examples, this edition also highlights new areas of application including cultural materials, forensic analysis, and environmental studies.This book illustrates how the latest advances make pyrolysis a practical, cost-effective, reliable, and flexible alternative for increasingly complex sample analyses. Analytical Pyrolysis Handbook, Third Edition is an essential, one-stop guide for determining if pyrolysis meets application-specific needs as well as performing pyrolysis and handling the data obtained.

This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs. 

Bioremediation using microbes is a sustainable technology for biodegradation of target compounds, and an omics approach gives more clarity on these microbial communities. This book provides insights into the complex behavior of microbial communities and identifies enzymes/metabolites and their degradation pathways. It describes the application of microbes and their derivatives for the bioremediation of potentially toxic and novel compounds. It highlights the existing technologies along with industrial practices and real-life case studies.Features:Includes recent research and development in the areas of omics and microbial bioremediation.Covers the broad environmental pollution control approaches such as metagenomics, metabolomics, fluxomics, bioremediation, and biodegradation of industrial wastes.Reviews metagenomics and waste management, and recycling for environmental cleanup.Describes the metagenomic methodologies and best practices, from sample collection to data analysis for taxonomies.Explores various microbial degradation pathways and detoxification mechanisms for organic and inorganic contaminants of wastewater with their gene expression.This book is aimed at graduate students and researchers in environmental engineering, soil remediation, hazardous waste management, environmental modeling, and wastewater treatment.

Rapid industrialization and intensive increase in agricultural activities has decreased the soil quality, fertility, thereby adversely impacting environment, which is a serious concern globally. This book will be covering various roles of biological as well as physico-chemical management technologies for environment sustainability.

This book approaches the topic of environmental biotechnology in a clear, integrated, and meaningful way, covering both the fundamentals and biochemical processes involved including technologies. It also provides thorough description of the pollution and pollution control & role of microbes in different ecosystems and deterioration processes.

Antimicrobial resistance has existed in nature long before the discovery of antibiotics. The mechanisms of resistance are prevalent among the bacterial population. Over a period of time and facilitated by indiscriminate usage of antibiotics, these mechanisms are transferred from one type of bacteria to another, including the pathogenic ones. In addition, the rate of discovery of novel antimicrobials is much slower than the rate of evolution of antimicrobial resistance. Therefore, there is a need for alternative strategies to control antimicrobial resistance to save lives. In this book, the novel strategies to combat antimicrobial resistance are described, emphasizing collaborative measures of control. We describe the concerted efforts undertaken by global communities to combat antimicrobial resistance in detail. The most efficient strategy could be a behavioral change towards indiscriminate consumption, usage, and prescription of antibiotics.

Die Patch-Clamp-Technik ist heute eine der wichtigsten neurophysiologischen Arbeitsmethoden. Ihre Anwendung hat in der biomedizinischen Grundlagenforschung bedeutende Erkenntnisse über die Funktion und die Eigenschaften von Ionenkanälen erbracht, und auch aus der angewandten pharmakologischen Forschung ist sie in­zwischen nicht mehr wegzudenken. Klar und praxisbezogen vermitteln die Autoren die wesentlichen Informationen, um die Methode im Labor einzuführen und erfolgreich anzuwenden. Das Buch erläutert die theoretischen Grundlagen der Messung, den detaillierten Aufbau eines Messplatzes und die praktische Durchführung typischer Messkonfigurationen. Konkrete Tipps und Tricks helfen beim ¿Trouble-Shooting¿ und sind nicht nur für Neuanwender eine unverzichtbare Hilfe.