Molekylærbiologi

This book, Clinical Biochemistry and Drug Development: From Fundamentals to Output, focuses on clinical biochemistry fundamentals, cell culture techniques, and drug discovery and development concepts. It deals with three different fields of clinical research: cell culture, clinical biochemistry, and drug discovery and development.

This volume on applied pharmaceutical science and microbiology looks at the latest research on the applications of natural products for drug uses. It focuses on understanding how to apply the principles of novel green chemistry methods in the vital area of pharmaceuticals.

Biocatalyst Immobilization: Foundations and Applications provides a comprehensive overview of biocatalytic immobilization processes, as well as methods for study, characterization and application. Early chapters discuss current progress in enzyme immobilization and methods for selecting and pretreating enzymes prior to immobilization, with an emphasis on navigating common challenges and employing enzyme supports and post immobilization treatments to impact enzymatic activity. Process-based chapters instruct on measuring and reporting on enzyme immobilization efficiency, protein final content, quantification of reaction products, and the use of nanomaterials to characterize immobilized enzymes. Later chapters examine recent advances, including novel enzymatic reactors, multi-enzymatic biocatalysts, enzymatic biosensors, whole cell immobilization, the industrial application of immobilized enzymes, and perspectives on future trends.

Sustainable Plant Nutrition: Molecular Interventions and Advancements for Crop Improvement explores the significant opportunities for sustainable, eco-friendly approaches in plant nutrition and agricultural crop production. The book highlights the various prospects involved in optimizing plant nutrient uptake agriculture and includes chapters representing diverse areas dealing with biotechnology, nanotechnology, molecular biology, proteomics, genomics and metabolomics. This book is an ideal resource for those seeking to ensure a sustainable plant production future. While plants have evolved a set of elaborate mechanisms to cope with nutrient limitations, the traditional supplementation by the application of fertilizers to plant productivity may then lead to overfertilization which can actually reduce plant growth and have adverse effects on the environment. To tackle these issues, a detailed understanding of the responses of plants to nutrients and nutrient deficiency at the physiological, metabolic, transcriptome and epigenetic level is essential.

This reprint contains original research and review articles describing recent advances in our understanding of the transcriptional regulation of cardiac development and disease mechanisms. All articles were originally published in the International Journal of Molecular Sciences (IJMS).

This book provides basic information and different protocols associated with the Entomopathogenic nematodes (EPNs) and their symbiotic bacteria. Entomopathogenic nematodes (EPNs) of the genera Steinernema and Heterorhabditis and their associated bacterial symbionts Xenorhabdus and Photorhabdus aid nematode infective juveniles (IJs) in infecting and killing their insect hosts, creating a unique tripartite complex of host-vector-symbiont interactions. Due to this insect killing capability, EPNs are used as biological control agents of economically important insect pests. They are also a model system to study host-parasite interactions.It provides a systematic approach to various nematode procedures including pathogenicity, reproduction, foraging behaviour. It gives a brief outline on historical aspects, nematode-bacterium complex, biology and chemical ecology of EPNs. It concisely describes host insect rearing, nematode samplingand storage, isolation techniques, counting, handling and staining of nematodes, characterization including morphological, molecular and ecological studies, mass production, virulence bioassay, field application and efficacy. The book also includes methods and techniques for their associated symbiotic bacteria.This book serves as a laboratory manual and assists the readers to undertake advanced research in different aspects related to nematodes. It is useful for researchers in the fields of nematology, microbiology, bacteriology and entomology.

A must for researchers in the biological sciences, this valuable book takes the time to explain something often taken for granted - buffers used in experiments. It answers the common questions such as: Which buffer should I choose? What about the temperature effects? What about ionic strength? Why is the buffer with the biggest temperature variation used in PCR? It is an indispensable guide for everyone using buffers, providing even the most experienced researchers with the means to understand the fundamental principles behind their preparation and use.

This book constitutes the thoroughly refereed post-proceedings of the 7th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2010, held in Palermo, Italy, in September 2010. The 19 papers, presented together with 2 keynote speeches and 1 tutorial, were carefully reviewed and selected from 24 submissions. The papers are organized in topical sections on sequence analysis, promoter analysis and identification of transcription factor binding sites; methods for the unsupervised analysis, validation and visualization of structures discovered in bio-molecular data -- prediction of secondary and tertiary protein structures; gene expression data analysis; bio-medical text mining and imaging -- methods for diagnosis and prognosis; mathematical modelling and simulation of biological systems; and intelligent clinical decision support systems (i-CDSS).

This two-volume set LNCS 6691 and 6692 constitutes the refereed proceedings of the 11th International Work-Conference on Artificial Neural Networks, IWANN 2011, held in Torremolinos-Málaga, Spain, in June 2011. The 154 revised papers were carefully reviewed and selected from 202 submissions for presentation in two volumes. The second volume includes 76 papers organized in topical sections on video and image processing; hybrid artificial neural networks: models, algorithms and data; advances in machine learning for bioinformatics and computational biomedicine; biometric systems for human-machine interaction; data mining in biomedicine; bio-inspired combinatorial optimization; applying evolutionary computation and nature-inspired algorithms to formal methods; recent advances on fuzzy logic and soft computing applications; new advances in theory and applications of ICA-based algorithms; biological and bio-inspired dynamical systems; and interactive and cognitive environments. The last section contains 9 papers from the International Workshop on Intelligent Systems for Context-Based Information Fusion, ISCIF 2011, held at IWANN 2011.

The sequencing of the genomes of humans and other organisms is inspiring the developmentofnew statisticalandbioinformatics tools that we hope canmodify the current understanding of human diseases and therapies. As our knowledge about the human genome increases so does our belief that to fully grasp the mechanisms of diseases we need to understand their genetic basis and the p- teomicsbehind them and to integratethe knowledgegeneratedin thelaboratory in clinical settings. The new genetic and proteomic data has brought forth the possibility of developing new targets and therapies based on these ?ndings, of implementing newly developed preventive measures, and also of discovering new research approaches to old problems. To fully enhance our understanding of disease processes, to develop more and better therapies to combat and cure diseases, and to develop strategies to prevent them, there is a need for synergy of the disciplines involved, medicine, molecular biology, biochemistry and computer science, leading to more recent ?elds such as bioinformatics and biomedical informatics. The 6th International Symposium on Biological and Medical Data Analysis aimed to become a place where researchersinvolved in these diversebut incre- ingly complementary areas could meet to present and discuss their scienti?c results. The papers in this volume discuss issues from statistical models to arc- tectures and applications to bioinformatics and biomedicine. They cover both practical experience and novel research ideas and concepts.

Synthetic Biology - A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.

This book examines how genetic parasites and addiction modules have been involved in the origin of toxins/antitoxins modules as systems of group identity. It traces the evolution of biological identity systems from molecules to human social structure.