Farmaceutisk kemi og teknologi

OPGAVER I FARMAKOLOGIMed Opgavekompendium i farmakologi kan den studerende tilegne sig færdigheder inden for farmakokinetisk og farmakodynamisk beregning og beskrivelse.Kompendiet er overskueligt opbygget med i alt 69 forståelses- og regneopgaver, hvor den studerende kan teste sin viden om 1-kompartmentkinetik, 2-kompartmentkinetik, renal farmakokinetik og farmakodynamik. Der er udførlige og pædagogiske svar til alle opgaver, således at det er muligt at kontrollere egne beregninger efter. Endvidere findes en formelsamling, der indeholder alle formler, som er relevante for at løse de enkelte opgaver.Opgavesamlingen er primært rettet mod medicinstuderende på alle landets universiteter, idet opgavernes niveau er afstemt med, hvad der kan forventes til eksamen i basal farmakologi. Kompendiet kan også anvendes af studerende inden for f.eks. molekylær medicin, odontologi, farmaci og lignende studieretninger, der tilbyder kurser i basal farmakologi.Bogen er skrevet af Peter Carøe Lind, Kim Brøsen, Ulf Simonsen og Jesper Krogh Lauridsen.

Plant-based medicines and aromatics are increasingly in demand in the healthcare sector all over the globe, where they are used, not only for the treatment of various diseases, but also for maintaining good human health. Plants as Medicine and Aromatics: Uses of Botanicals reviews modern uses of ancient botanicals as medicine and aromatics, including chapters on both traditional usage to modern drug discovery development, as well as clinical research and development in ancient medicinal herbs.FeaturesAssesses the status of aromatics and medicinal plants as well as their modern uses.Elucidates the uses of plants within traditional culture practices for the prevention and treatment of diseases.Examines contemporary approaches being used to explore medicinal botany.A volume in the Exploring Medicinal Plants series, Plants as Medicine and Aromatics: Uses of Botanicals presents a comprehensive understanding in terms of modern uses of botanicals of medicinal and aromatic plants. It is useful to researchers, teachers, cultivators, students, and for those interested in herbal medicine.

En præcis og opslagsvenlig guide til brug af lægemidler i praksis – nu i 3. udgave."Praktisk farmakologi" henvender sig til den sundhedsprofessionelle, der har brug for et overblik over den praktiske brug af receptpligtige lægemidler og håndkøbslægemidler – særligt farmaceutstuderende og farmakonomer, men også hjemmesygeplejersker, medicinstuderende og læger.Denne 3. udgave er blevet grundigt opdateret og væsentlig forbedret med den nyeste viden og et væld af erfaringer fra klinisk praksis. Bogen indeholder kort og præcis information om de 100 mest solgte lægemiddelgrupper i Danmark. Bogen giver dig: lægemidlernes navne, hvilke sygdomme de bruges til at behandle, hvordan de virker, de vigtigste bivirkninger, særlige oplysninger.Bogen gennemgår desuden de 25 hyppigste problemer, som kan løses ved brug af håndkøbslægemidler, samt de vigtigste fakta om naturlægemidler, lægemiddelinteraktioner, receptlovgivningen og reglerne for tilskud til medicin.

Pharmaceutical chemistry (PC) represents a dynamic field of research that plays a pivotal role in the development of life-saving pharmaceuticals. PC is a precise science: One needs to rely on the accuracy of previous discoveries that have provided massive amount of precious information and databases as a solid foundation to move forward. PC is also an art where the artist uses a subtle mixture of knowledge, experimental learning, creativity, intuition, boldness, and serendipity to paint the right canvas. Nature often serves as a stimulus for pharmaceutical chemists. Many drugs are derived from natural compounds found in plants, fungi, or microorganisms. Chemists study these natural sources, seeking inspiration to design synthetic molecules that mimic the therapeutic properties of the originals while optimizing their characteristics. Francis Collins, geneticist and expert in the pharmaceutical industry, explains that the molecular cause of 4,000 diseases is no longer a secret to humanity, but there are only treatments available for 250 of them. Therefore, the world requires more professionals who can produce better medicines and solve more needs. For this reason, it is urgent to discover a new system, new drugs, better industrial processes and faster responses for rare and complex diseases. That is the importance and need for more students in love with PC. It is the author's wish that volumes 1 and 2 of this series may serve as motivation for students who intend to get started in the exciting world of drug design, synthesis and development. There is no nobler objective than improving health and quality of life of the human race. The unprecedented increase in human life expectancy, which has almost doubled in a hundred years, is mainly due to drugs and to those who discovered them. It is more important to create awareness in the student that he/she is responsible for his own learning and not simply a passive consumer of information. In this way we will be able to train versatile professionals with an attitude of transformative social change. Drug Design and Action is trated in a separate volume ISBN 978-3-11-131654-3.

The term nutraceuticals is applied to the products isolated from the herbal sources, nutrients or dietary supplements, processed foods, (cereals, soup and beverages) and specific diets, that may also used as medicine other than nutrition. It usually refers to the foods derived products which may sell in medicinal form, possessing physiological benefits to the host while promoting health and wellness and provide protection against chronic disorders. They may also increase the life expectancy, delay the aging and/or support the structure and function of the body organs. Demand for nutraceuticals with potential to prevent and treat chronic disorders has been interestingly increasing over the past few years. Based on food sources, nutraceuticals are classified into dietary fibers, probiotics, prebiotics, polyunsaturated fatty acids (PUFAs), vitamins, polyphenols and spices. A dietary supplement is generally considered as product containing vitamins, minerals, amino acids, and medicinal plants that are indented to be used to supplement the diet or a concentrate, metabolite, constituent, extract, or combinations of these ingredients. Broadly, nutraceuticals are any of these ingredients or supplements using for health purposes other than nutrition. This book on the fundamentals of Nutraceuticals is organized in two parts i.e., the introductory aspects of macro- and micro-nutrients, gut microbiota regulation, nutraceuticals and drug interactions, while the second part is focusing on the biological benefits of nutraceuticals in different disease states. Besides, this book is also addressing the safety aspects of nutraceuticals and phytotherapeutic support in pregnancy. Including contributions from the experts in the field, target audience (pharmacists, nutritionists, other healthcare providers, and researchers in food and nutrition sector) will be benefited with the updated literature on nutraceuticals and dietary supplements.

Biocontamination Control for Pharmaceuticals and Healthcare, Second Edition outlines a biocontamination strategy that tracks bio-burden control and reduction at each transition in classified areas of a facility. The first edition of the book covers many of the aspects of the strategy, but the new official guidance signals that a roadmap is required to fully comply with its requirements. Completely updated with the newest version of the EU-GPM (EN17141), this new edition expands coverage of quality risk management and contains completely new examples to help professionals bridge the gap between regulation and implementation. This book offers professionals in pharma quality control and related areas guidance on building a complete biocontamination strategy.

The Pharmacognosy and Phytochemistry-II book is comprehensive guidance in lucid writing for following theory as well as experimental topics:Theory topics · Biosynthesis of plant metabolites · Popular plants containing therapeutically important Secondary metabolites · Isolation, Identification and Analysis of Phytoconstituents · Industrial production, estimation and utilization of the phytoconstituents · Traditional and Modern Methods of extraction · Applications of Chromatography, Electrophoresis, spectroscopyExperiments · Morphological, histological, powder microscopical and chemical characteristics of crude drugs · Isolation of phytochemicals · Extraction of volatile oils · Separation of sugars by Paper chromatographyContents:Part - I: Pharmacognosy and Phytochemistry-II (Theory) 1. Metabolic Pathways in Higher Plants and their Determination2. General Introduction3. Isolation, Identification and Analysis of Phytoconstituents4. Industrial Production, Estimation and Utilization5. Basics of Phytochemistry Part - II: Practical Manual

Instrumental Methods of Analysis imparts fundamental knowledge on the principles and instrumentation of some of the most commonly used spectroscopic and chromatographic techniques. This book caters to the need of the students and analysts in various fields for a thorough understanding of the construction of various analytical instruments and their principles. A detailed study of the book will make the readers proficient in spectroscopic and chromatographic techniques that are covered in the book, their applications including limitations. The book is divided into two sections: The first section covers the spectroscopic techniques. All the topics of this section include a detailed description of the concepts involved, instrumentation and applications of different techniques with illustrations. The second section describes the different chromatographic techniques which include an introduction to chromatography. This section gives a detailed note on various terminologies used in chromatography along with theoretical knowledge on the methodology, stationary and mobile phases along with their applications and limitations.

To ensure that the students can understand the concept and contents, the book has been written in a clear language. Each subject has been thoroughly explained. However, certain things that are significant and valuable are covered. This will make it easier for the students to connect their theoretical learning to the real-world needs of the pharmaceutical sector.The course would make all the students understand at least the following:· Know the process of pilot planting and the scale of pharmaceutical dosage forms· Understand the process of technology transfer from lab scale to commercial batch· Know different Laws and Acts that regulate the pharmaceutical industry· Understand the approval process and regulatory requirements for drug products

This book provides an excellent platform for understanding the chemical processes involved in food transformation. Starting with the examination of major food components, such as water, carbohydrates, lipids, proteins and minerals, the author further introduces the biochemistry of digestion and energy metabolism of food ingredients. The last section of the book is devoted to modern food technologies and their future perspectives.

The fourth edition of Process Validation in Manufacturing of Biopharmaceuticals is a practical and comprehensive resource illustrating the different approaches for successful validation of biopharmaceutical processes.

This book focuses on the property of essential oil and discusses competency of essential oil in treating disorders like diabetes, insomnia, depression, nausea, anxiety, and stress and other practical topics obligatory for the development of essential oils industry.

This book provides a broad range of applications and recent advances in the search for biofilm materials in nature. It also explains the future implications for biofilms in the areas of advanced molecular genetics, pharmaceuticals, pharmacology, and toxicology. This book is comprised of 20 chapters from leading experts in the field and it examines immunology and microbiological studies derived from biofilms as well as explores environmental, agricultural, and chemical impacts on biofilms. It is divided into five subdivisions: biofilms and its complications, biofilm infections in human body, detection of biofilm-forming pathogens, antibiofilm chemotherapy, and biofilms production tools in aquaculture. This book may be used as a text or reference for everyone interested in microbial biofilms and their current applications. It is also highly recommended for environmental microbiologists, medical microbiologists, bioremediation experts, and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing, and many other related areas. Scientists in academia, research laboratories, and industry will also find it of interest. This book includes chapter homework problems and case studies. Powerpoints are also available for adopting instructors.Discusses and clarifies the resource of isolation and chemical properties from biofilmsDiscusses the latest pharmaceutical, pharmacological, and medicinal approaches toward the treatment of chronic and uncured diseases, such as Alzheimer's osteoporotic, sexual dysfunction, sleep sickness, allergy treatment, asthma, hair loss, AIDS, hypertension, antiaging, etc. Examines immunology and microbiological studies derived from biofilms Explores environmental, agricultural, and chemical impacts on biofilms.Dr. Bakrudeen Ali Ahmed Abdul is an Associate Professor, the Head of the Department of Biochemistry and Dean of the School of Life Sciences, Centre for Research and Development (CRD), PRIST Deemed University, Vallam, Thanjavur, Tamil Nadu, India. His research areas include the application of plant biochemistry, bioactive compound production, biotechnological methods, development of pharmaceutical products and pharmacological studies.

Methodologies for Biosimilar Product Development covers the practical and challenging issues that are commonly encountered during the development, review, and approval of a proposed biosimilar product. These practical and challenging issues include, but are not limited to the mix-up use of interval hypotheses testing (i.e., the use of TOST) and confidence interval approach, a risk/benefit assessment for non-inferiority/similarity margin, PK/PD bridging studies with multiple references, the detection of possible reference product change over time, design and analysis of biosimilar switching studies, the assessment of sensitivity index for assessment of extrapolation across indications without collecting data from those indications not under study, and the feasibility and validation of non-medical switch post-approval.Key Features:Reviews withdrawn draft guidance on analytical similarity assessment.Evaluates various methods for analytical similarity evaluation based on FDA's current guidelines.Provides a general approach for the use of n-of-1 trial design for assessment of interchangeability.Discusses the feasibility and validity of the non-medical switch studies.Provides innovative thinking for detection of possible reference product change over time.This book embraces innovative thinking of design and analysis for biosimilar studies, which are required for review and approval of biosimilar regulatory submissions.

The book manuscript covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants.

Chapters collected from "The Virtual Conference on Chemistry and its Applications (VCCA-2021) - Research and Innovations in Chemical Sciences: Paving the Way Forward". This conference was held in August 2021 and organized by the Computational Chemistry Group of the University of Mauritius. These peer-reviewed chapters offer insights into research on fundamental and applied chemistry with interdisciplinary subject matter.

The digital supply chain in a pharmaceutical company is known as the strategic and operative exchange of information (product, design, research, and competition) between stakeholders, such as suppliers, manufacturers, logistics service providers, customers, and regulatory agencies (Singh et al., 2016). The digitalization in supply chain helps build a new type of sustainable, responsive, and resilient supply network because the complex pharmaceutical supply chain involves life-saving interests and requires the mandatory participation of stakeholders (Haddud et al., 2017; Korpela et al., 2017).Digitalization has fostered a new era of competitiveness using digital strategies, digital enablers, digital system integrators, and application technologies (Ehie & Ferreira, 2019). Using digitalization to reduce operational costs and make the process effective is thus anecessity for profitability in a pharmaceutical industry.

Despite its great contribution to improving the health and well-being of people and saving countless lives worldwide for over a century, the modern pharmaceutical industry has continued to fall from grace in public perception for the last ten to fifteen years.While there are many reasons, such as ever-escalating prices denying access to many patients, unethical business practices to gain market share, and relentless focus on the bottom line explain for low productivity, they cannot be responsible for Pharma's loss of reputation. Instead, most pharmaceutical companies' transactional marketing and other unethical business practices seem to be a major, if not the only, cause of the drug industry's fall on the reputation barometer. Increasing competition, drying up of new product pipelines, rapid genericization, and continuing cost-containment pressures are the reasons a marketer practicing transactional marketing would offer. But, then, there is often a very thin line between a reason and an excuse. Excuses, when accepted, become reasons, and reasons, when denied, become excuses. Regardless of whether there are reasons or excuses, transactional marketing practices and unethical business behavior may give short-term gains in business at a huge cost to reputation, which is extremely difficult to rebuild. Moreover, transactional relationships are so transient, like fleeting clouds, that they cannot build loyalty for your brand or company. Only Transformational marketing practices and ethical business behavior can.Pharma needs to change its marketing practices from transactional to transformational today. The question is how? The book, Transactional to Transformational Marketing aims to show how a pharma company can do this because the cure for all current marketing ills is Transformational Marketing!

The book is application oriented highlighting the new trends within Indian Pharmaceutical Industry, Challenges that Marketers are likely to face & the Strategies that they can adopt. It is also designed keeping in mind the Pharmaceutical & Healthcare management programs taught at various B-schools. This book serves as a reference book for pharma marketers and the students of Pharmaceutical & Healthcare Management Programs. This book can be a part of Brand Manager's library - a book s/he can refer to whenever s/he has to clarify concepts.Highlights of the Book · Covers marketing concepts which a pharma marketer needs to know · It focuses on latest concepts and examples · Provides frameworks that can be applied on-the-job · A summary is given at the end of each chapter for quick reference · It is backed by author's Industry experience coupled with academic experience of teaching the subject to students undergoing management program in Pharmaceutical & Healthcare ManagementBook is for whom? · Pharma Industry Marketing Practitioners · Students undergoing a Pharmaceutical /Healthcare Management Program

"In the 1970s, Dr. Alan Scott sought to selectively weaken eye muscles to treat strabismus (when one or both eyes are misaligned) without surgery. After failed attempts with other agents, Scott developed a method to stabilize the bacteria that causes botulism, culminating in a drug that eventually became known as Botox. In Death to Beauty, Eugene M. Helveston, MD, follows the unlikely story of botulism's 1817 discovery in contaminated German sausages, to its use in military and research facilities, to Scott, an ophthalmologist who aimed to safely use the drug in humans. Scott struggled alone as an unknown in the pharmaceutical industry, searching for clinical trial financing and FDA approval, which he achieved at a fraction of the billions big pharma usually spends to bring a drug to market. Eventually, the company Allergan bought him out, capitalizing on the possibilities for cosmetic uses. Scott's formula was renamed "Botox" and reached annual sales in the billions. After the sale, Scott received no further compensation from Botox sales and remained the same unassuming man.A fascinating walk through the intricate history of how the world's deadliest toxin starting as a treatment for crossed eyes became a routine tool for the cosmetic industry, Death to Beauty will make you rethink success, beauty, and deadly bacteria"--

Bioresorbable Polymers and their Composites: Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development provides a holistic view of these unique materials and their usage in a range of biomedical applications. The book is evenly divided between fundamentals, processing methods and modeling approaches, and includes detailed coverage of a variety of applications, such as drug delivery, medical devices and wound healing. Key aspects including biocompatibility, biodegradability and toxicology are also thoroughly covered, enabling the reader to be fully informed when fabricating and utilizing their selected bioresorbable polymer. This book is an interdisciplinary and important reference for researchers in the fields of materials science, biomedical engineering, pharmaceutical science and regenerative medicine, as well as R&D groups in the development of medical devices.

Drug counterfeiting detection is very important for the safety of patients globally. Counterfeit detection devices have been used for qualitative and quantitative assessment to differentiate counterfeit medications from the relevant product. This volume focuses on current technological approaches to detect counterfeited pharmaceuticals.

This book equips readers with a comprehensive understanding of microneedles; from percutaneous absorption to microneedles production, characterization, applications in drug delivery and diagnosis, to practical perspectives on the development, manufacturing, regulatory issues, and commercialization of microneedles.

A variety of bioactives and therapeutics from the legume family (Fabaceae or Leguminosae) are thoroughly detailed. For each species included in the volume, a brief introduction is given, the plant¿s bioactive compounds are listed, and their chemical structures shown, followed by their pharmacological activities.

This volume in the Exploring Medicinal Plants series provides an overview natural healing treatments in selected antidiabetic plants.

Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development aims at showcasing different structure-based, ligand-based, and machine learning tools currently used in drug design. It also highlights special topics of computational drug design together with the available tools and databases. The integrated presentation of chemometrics, cheminformatics, and machine learning methods under is one of the strengths of the book. The first part of the content is devoted to establishing the foundations of the area. Here recent trends in computational modeling of drugs are presented. Other topics present in this part include QSAR in medicinal chemistry, structure-based methods, chemoinformatics and chemometric approaches, and machine learning methods in drug design. The second part focuses on methods and case studies including molecular descriptors, molecular similarity, structure-based based screening, homology modeling in protein structure predictions, molecular docking, stability of drug receptor interactions, deep learning and support vector machine in drug design. The third part of the book is dedicated to special topics, including dedicated chapters on topics ranging from de design of green pharmaceuticals to computational toxicology. The final part is dedicated to present the available tools and databases, including QSAR databases, free tools and databases in ligand and structure-based drug design, and machine learning resources for drug design. The final chapters discuss different web servers used for identification of various drug candidates.

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series. For Volume 54, the series editors have invited established chemists to offer cutting-edge reviews of chromatographic methods applied in the life sciences that emphasize the underlying principle of separation science.

Polysaccharides are natural, renewable materials that are biodegradable and biocompatible, making them ideal subjects for biomedical applications. This book focusses on the main polysaccharides, including but not limited to chitosan, cellulose, alginate, dextran, guar gum, gellan gum, pullulan, locust bean gum, pectin, xanthan gum, starch, hyaluronan and carrageenan, and their applications in drug delivery, imaging and tissue engineering. With contributions from around the world, the editors have pulled together a tightly curated set of chapters which showcase how polysaccharide-based materials are employed in a range of biomedical systems. The end result is a book in which the reader can gain a sound overview of this important class of material for biomedical applications, without scouring journal articles. Those working in materials science, biomedical and chemical engineering, and pharmaceutical technologies will find this a must-have reference.

Vaccine development is a complex and time consuming process that differs from the development of conventional pharmaceuticals. Primarily, vaccines are intended for use in healthy individuals as a preventative measure, requiring a long and rigorous process of research and many years of testing and development prior to clinical trials and regulatory approval. The average time for the development of vaccines to clinical is 12 to 15 years. Vaccine Development: From Concept to Clinic is a detailed overview of the development of new vaccines, covering the entire process and addresses all classes of vaccines from a processing, development and regulatory viewpoint. Utilising successful case studies the book will provide insight to the issues scientists face when producing a vaccine, the steps involved and will serve as an ideal reference tool regarding state-of-the-art vaccine development. This book is an ideal companion for any researchers working in vaccine discovery and development or with an interest in the field.