Bøger udgivet af Cold Spring Harbor Laboratory Press,U.S.

Parkinson's Disease is an incurable neurodegenerative disease characterized by a progressive loss of dopaminergic neurons that leads to slowness of movement, muscle rigidity, and tremors. Insoluble aggregates of proteins such as alpha-synuclein accumulate in the affected neurons, which also appear to be subject to oxidative stress. This collection from Cold Spring Harbor Perspectives in Medicine discusses recent work that has begun to uncover the molecular mechanisms that underlie the condition, including studies that implicate dysfunction of mitochondrial proteins such as parkin and pink1.

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing cells in the pancreas by the body's immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of

The behavior of lymphocytes in the immune system depends on encounters with antigens. These bind to immunoreceptors on the surface of T-cells and B-cells, activating a variety of signal transduction pathways that control cell survival, proliferation, differentiation, and effector functions. Written and edited by experts in the field, this volume is essential reading for systems biologists as well as all immunologists and cell biologists interested in understanding how lymphocytes function.

Many human diseases--including Alzheimer's disease, schizophrenia, cancer, and cardiovascular disease--show complex inheritance that requires sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book's chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance.

Signaling by diffusible morphogens, such as Hedgehog, Wingless, TGF-, and various growth factors, is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues. The expert contributors to this volume discuss the roles of morphogen gradients in organisms from yeast to humans. They examine the regulation of morphogen synthesis, trafficking, and diffusion, as well as the complex webs of signaling mechanisms and transcriptional responses in recipient cells. The book is a vital reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis.

Comprised of review articles reprinted from the tenth anniversary issue of the journal "Genome Research" that capture the status of genetic research in a collection of model species, this volume serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology.

This is the first book to provide a detailed and thoroughly up-to-date review of the complexity of DNA replication in eukaryotic cells. It is organized into three parts: Concepts, a distillation of underlying principles; Enzymes, a description of each protein class involved; and Systems, a review of events over a wide range of organisms. The book is therefore invaluable for teachers who want a current survey of a topic central to the biology syllabus: investigators of replication who will appreciate a remarkably concise, central source of knowledge in their specialty; and scientists studying other biological functions on which DNA replication has an impact.

Highly illustrated and based heavily on early 20th century original sources, the book traces the roots of genetics in breeding analysis and studies of cytology, evolution, and reproductive biology that began in Europe but were synthesized in the United States through new Ph.D. programs and expanded academic funding. Readable and original, this narrative will interest historians and science educators as well as today's practitioners of genetics.

Ageless Quest is a personal, sometimes controversial, account of the pursuit of a genetic 'cure' for aging by an expert in the field. The author is the Novartis Professor of Biology at the Massachusetts Institute of Technology. Aging has always been regarded as a highly complex process with many degenerative changes leading to the cessation of life. But recent research has identified a relatively simple mechanism that governs the pace of aging. Lenny Guarente's Ageless Quest is a scientific detective story for the baby boom generation. It offers an insider's view of an area of potentially astonishing high reward--and equally high risk.

Reilly discusses over 90 common conditions, diseases, and disorders, arranged from conception to old age. In frank, non-technical terms, he makes clear what is known and not known about the genetic factors and, if your risk is elevated, what you might be able to do about it. This book is a uniquely valuable resource for anyone seeking more information about a family's disease heritage.

This advanced microscopy manual includes established and evolving methods for studying metabolic and developmental changes in living cells and organisms. It is divided into two sections: the first covers the principles of detection and imaging approaches, and the second deals with detailed protocols for imaging live cells, organelles, and organisms.

Selected by his daughter Vivien, these letters chronicle Perutz's life through his own vivid, erudite, and humorous pen. With a spontaneity and directness no autobiography can match, this volume captures the hopes, roadblocks, and moments of elation throughout his 60-year quest to understand the molecular biology of hemoglobin.