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This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy.Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis. The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.
This book examines critically how the Chinese government has proactively engaged the nine cities and two special administrative regions in the Greater Bay Area (GBA) in Southern China for deeper collaborations in order to transform the country from the ¿World Factory¿ to become a leading world economy in innovation and entrepreneurialism. While most of the existing research related to Chinäs GBA development offers the economic and technological advancement perspectives, this book focuses on critical reflections upon how the call for megacity development and deeper regional collaborations in the Bay Area will affect people¿s livelihoods, social integration and urban governance. The central theme of this book builds around ¿Cities, Social Cohesion and Governance.¿ Based upon policy and document analysis, first-hand fieldwork and surveys, and intensive interviews with major stakeholders responsible for pushing the Greater Bay Area development, this book offers not only regional perspectives in analyzing the Greater Bay Area development through comparing and contrasting development experiences within the country¿s different bay economies like the Shanghai and Zhejiang Bay Area and Beijing and Bohai Bay Area. The present book also draws comparative and international insights from other well- established bay economies like Tokyo Bay, Florida Bay and New York Bay Areas when analyzing the development in the GBA in China.
This book presents select proceedings of the International Virtual Conference on Trends in Hydrological and Environmental Systems (ITHES 2021). Various topics covered in this book include urban hydrology, hydrological extremes, statistical analysis of hydro-meteorological data, impacts of climate change, hydrological modelling, groundwater studies, water resource management and applications of RS & GIS in hydrology. The book also discusses various topics on applications of CFD in water resources and environmental engineering, water and wastewater treatment, solid waste management and air quality. The book will be a valuable reference for beginners, researchers, and professionals interested in environmental civil engineering, especially hydrological and environmental systems.
This volume comprises select proceedings of the International Conference on Humanizing Work and Work Environment organized by the Indian Society of Ergonomics (HWWE2019). The book presents research findings on different areas of ergonomics for developing appropriate tools and work environment considering capabilities and limitations of working people for maximum effectiveness on their performance. This volume will be of interest to academics, professionals and practitioners in the field of ergonomics.
The book comprises state-of-the-art scientific reviews on carbon management strategies in response to climate change. It provides in-depth information on topics relating to recent advances in carbon capture technology and its reuse in value added products. It features contributions of leading scientists and technocrats on topics including climate change and carbon sequestration, lowering carbon footprint CO2 capture, low carbon imperatives in oil industry, CO2 as refrigerant in cold-chain application, carbonic anhydrase-mediated carbon sequestration and utilization, chemical looping combustion with Indian coal, CO2 conversion to chemicals, algae based biofuels, and carbon capture patent landscaping analysis. The contents of this book will be helpful for research scholars, post-graduate students, industry, agricultural scientists and policy makers/planners.
This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
This book examines the childhood education policy development in China. It involves investigating the holistic landscape of China's childhood development from a policy perspective. It also offers a specific lens to examine the migrant childhood education policy in China, the left-behind childhood education policy in China, the ethnic childhood education policy development in China, the special childhood education policy in China, and the boarding schools' childhood education policy in China. The intended readers are scholars and researchers who are interested and work in research on China's childhood education reform/pre-K-12 in China. The administrators and stakeholders in Chinese education system and graduate students are majoring and minoring in the field of educational policy.
The book presents selected papers at the 9th Conference on Sound and Music Technology (CSMT) held virtually in June 2022, organized by Zhejiang University, China. CSMT is a multidisciplinary conference focusing on audio processing and understanding with bias on music and acoustic signals. The primary aim of the conference is to promote the collaboration between art society and technical society in China. In this book, the paper included covers a wide range topic from speech, signal processing, music understanding, machine learning, and signal processing for advanced medical diagnosis and treatment applications, which demonstrates the target of CSMT merging arts and science research together. Its content caters to scholars, researchers, engineers, artists, and education practitioners not only from academia but also industry, who are interested in audio/acoustics analysis signal processing, music, sound, and artificial intelligence (AI).
This book reflects the great changes in terms of real estate sales, purchases, finance and policies from planned economy to market economy in China. Real estate system has always been a great concern to the public for its irreplaceable role in people's lives and various daily affairs, as well as in the development of the whole economy, especially in China's context. The unique perspective of this book lies in the significant role that the Chinese government plays in real estate system. This book aims to help readers to understand China's real estate system comprehensively.
This book examines the idea of opening education to the outside world in China since post-COVID-19. It investigates the historical development of international education development in China and explores the internationalization of education system from various dimensions. It also discusses the history of studying abroad at public expense since the 18th National Congress of the Communist Party of China, as well as studying abroad at our own expense in China from the perspective of departmental coordination, Sino-foreign cooperation of running schools in China, Confucius Institutes' development in China, Luban Workshop Development in China, and running Chinese-foreign cooperation education in China. In addition, this book also offers specific suggestion to address various problems of international education development in China during post-COVID-19. This book will be particularly interest to scholars and researchers who are interested and work in research on China international education development.
This book features selected papers presented at the 20th International Conference on Near Infrared Spectroscopy. It discusses the latest progress in the field of near infrared spectroscopy from around the globe, including the advances in instrumentation, spectral interpretation and Chemometrics. In addition, it presents potential trends for near infrared spectroscopy in the next decade and highlights developments in process analytical technology, chemical imaging and deep learning. It can be used as a reference book for researchers and application personnel engaged in spectroscopy technology, Chemometrics, analytical instruments, on-site rapid or on-line analysis, process control and other fields. It will also be useful for undergraduates and postgraduates studying these topics.
This book offers an exploration of the postcolonial hybrid experience in anglophone Caribbean plays and performance from a feminist perspective.In a hitherto unattempted consideration of Caribbean theatre and performance, this study of gendered identities chronicles the postcolonial hybrid experience - and how it varies in the context of questions of sex, performance and social designation. In the process, it examines the diverse performances of the anglophone Caribbean. The work includes works by Caribbean anglophone playwrights like Derek Walcott, Mustapha Matura, Michael Gikes, Dennis Scott, Trevor Rhone, Earl Lovelace and Errol John with more recent works of Pat Cumper, Rawle Gibbons and Tony Hall. The study would also engage with Carnival, calypso and chutney music, while commenting on its evolving influences over the hybrid imagination.Each section covers the dominant socio-political thematics associated with the tradition and its effect on it, followed by an analysis of contemporaneously significant literary and cultural works - plays, carnival narrative and calypso and chutney lyrics as well as the experiences of performers. From Lovelace's fictional Jestina to the real-life Drupatee, the book critically explores the marginalization of female performances while forming a hybrid identity.
In a context in which explicit attention to the curriculum has been sidelined in universities' strategy, this book makes an argument for why curriculum matters, both in understanding the effects of unbundled online learning and more broadly. It takes up two particular curriculum issues which are amplified in an unbundled context: differences in the formulation of curriculum between disciplines and professional fields, and the extent these are recognised in university strategy; and the push for constructivist pedagogies, and its effects on curriculum construction. Since the onslaught of MOOCs in 2012, unbundled forms of online learning offered via partnerships with external online program management and MOOC providers have grown significantly across the university sector. There has been much debate about the implications of these partnerships but the focus has predominantly been on the engagement of students and their learning. This book takes a different and novel approach, looking instead at the effects on curriculum and knowledge.Drawing on selected case studies, the book reflects on how university leaders and academics engaged with MOOCs and other forms of unbundled online learning in the early 2010s, and the effects of these reforms on curriculum practice. It captures in detail the complex and difficult work involved in university curriculum making in a way rarely seen in discussions of higher education. And it generates new in-sights about some of the critical problems manifest in the ongoing moves to embrace unbundled online learning today.
This book provides an archival forum for researchers, academics, practitioners, and industry professionals interested and/or engaged in the reform of the ways of teaching and learning through advancing current learning environments towards smart learning environments. It facilitates opportunities for discussions and constructive dialogue among various stakeholders on the limitations of existing learning environments, need for reform, innovative uses of emerging pedagogical approaches and technologies, and sharing and promotion of best practices, leading to the evolution, design and implementation of smart learning environments. This book also focus on the interplay of pedagogy, technology and their fusion towards the advancement of smart learning environments.
This book is a compilation of the best papers presented at the 2021 edition of the Singapore Conference of Applied Psychology (SCAP) organised and facilitated by East Asia Research in Singapore. The selection of papers addresses the latest innovations, trends, concerns and practical challenges encountered in the field, and poses practical solutions within the field of applied psychology. The theme for 2021 is psychological well-being, and so the collection covers aspects of clinical and non-clinical psychological well-being in different arenas, from education to the workplace. Following a rigorous peer-review process led by the School of Psychology at the University of Derby, this collection is a valuable resource for academics, researchers and practitioners looking to keep themselves up-to-date with recent research in the field. The book is of interest to educators and practitioners in applied psychology focused on well-being.
This book presents an overview on ten years of rich experience and innovative development of scientific research around pedagogy, didactics and educative technologies at Cadi Ayyad University. From active learning in traditional teaching to technology enhanced learning, many efforts have been done so far by both researchers and PhD students making from Science Education an essential pillar that should bring innovative solutions and improve quality in teaching and learning in classes. 13 different topics have been selected and converted to chapters summarizing a decennia of active and open research works at the university. The selected chapters are a compilation of initiatives of research that Cadi Ayyad University team's are developing and experimenting among students. This compilation is unique in the field and country, so that it provides a innovative view on how some key topics are addressed in Higher Education.
This book addresses the need for a technical guided thought on production, consumption, and waste management of plastic and polymers in the African continent. Issues such as resource availability, processing technologies, plastic policies, and much more are covered in the book. While Africa is made up of several different countries which might be different from each other in many ways, these countries within the African continent have some commonalities such as region, some shared history, resources, and some shared policies through organizations such as the African Union, African Free trade Zone, and ECOWAS. With a population of over a billion, the African continent has become an attractive market for various businesses. Several publications in recent years have pushed for the advancement of the African continent toward increased manufacturing as a road to development. This inevitably includes the plastics and other polymers industry. Careful consideration must be taken to ensure that this growth will focus on more sustainable and greener manufacturing; otherwise, this anticipated growth in the plastics and polymer industry will only spell increased pollution and worsening of the environment.
This book examines the management of multiple goals in organizations especially in today's increasingly turbulent business environment. In this book, authors develop a novel concept of goal polychronicity, wherein organizations may attend to multiple goals simultaneously, rather than mono-chronically through sequential attention. This book further investigates the impact of internal organizational control systems and external environmental turbulence on multiple goals management. Empirical evidence is drawn from in-depth interviews of top executives and large-scale survey of top executives from four countries (US, Australia, China, and Israel). The book enriches the understanding of multiple goals and provides evidence-based recommendations to researchers and practitioners in managing multiple goals.
This book of CRIOCM 2021 (26th International Conference on Advancement of Construction Management and Real Estate) presents the latest developments in real estate and construction management around the globe. The conference was organized by the Chinese Research Institute of Construction Management (CRIOCM) working in close collaboration with Tsinghua University. Written by international academics and professionals, the book discusses the latest achievements, research findings and advances in frontier disciplines in the field of construction management and real estate. Covering a wide range of topics, including building information modeling, big data, geographic information systems, housing policies, management of infrastructure projects, intelligent construction and smart city, real estate finance and economics and urban planning and sustainability, the discussions provide valuable insights into the implementation of advanced construction project management and real estate market in China and abroad. The book offers an outstanding resource for academics and professionals.
The edited book brings out a comprehensive synthesis of latest scientific literature covering various important aspects of anaerobic biodigesters for human waste management that ranges from latest understanding on fundamental concepts/mechanisms of anaerobic biodigestion, modern tools and techniques used in process evaluation, current strategies being recruited for the performance enhancement, and case studies/ success stories across the world on applications of biodigesters used in human waste treatment.The anaerobic biodigestion is a process of break-down of organic waste by anaerobic microorganisms in absence of the oxygen. This process has been conventionally used for treating various types of organic waste including sewage sludge. After optimizing various process parameters, researchers have developed anaerobic biodigesters that have been successfully used for human waste (nigh soil) treatment. The topic of human waste treatment assumes global significance in the wake of UN sustainable Development Goals (SDG) wherein SDG-6 specifically highlights the Sanitation for all by 2030. The anaerobic Biodigester technology has the potential to manage the human waste as well and can contribute immensely in achieving targets of UN-SDG-6. This book is of interest to researchers, academicians, scientists, policy officials and capacity builders. Also the book serves as additional reading material for undergraduate and graduate students of environmental Biotechnology. National and international biotechnologists, environmental engineers and sanitation experts also find this to be a useful read.
Network Function Virtualization (NFV) has recently attracted considerable attention from both research and industrial communities. Numerous papers have been published regarding solving the resource- allocation problems in NFV, from various perspectives, considering different constraints, and adopting a range of techniques. However, it is difficult to get a clear impression of how to understand and classify different kinds of resource allocation problems in NFV and how to design solutions to solve these problems efficiently.This book addresses these concerns by offering a comprehensive overview and explanation of different resource allocation problems in NFV and presenting efficient solutions to solve them. It covers resource allocation problems in NFV, including an introduction to NFV and QoS parameters modelling as well as related problem definition, formulation and the respective state-of-the-art algorithms.This book allows readers to gain a comprehensive understanding of and deep insights into the resource allocation problems in NFV. It does so by exploring (1) the working principle and architecture of NFV, (2) how to model the Quality of Service (QoS) parameters in NFV services, (3) definition, formulation and analysis of different kinds of resource allocation problems in various NFV scenarios, (4) solutions for solving the resource allocation problem in NFV, and (5) possible future work in the respective area.
This book systematically summarizes the advanced development of carbon-based nanomaterials for electrochemical catalysis, and it is comprised of four sections. The first section discusses about the fundamental synthesis, characterization techniques, and catalytic effects on the energy conversion and storage mechanism. The second section elaborately reviews various types of electrocatalytic reactions on carbon-based materials and their performance. The third section focuses on batteries about carbon-based materials with different storage mechanism. And the last one, the following enlightenment in terms of theoretical development and experimental research is provided to the general readers: 1) Precise design and construction of local atomic and electronic structures at the interface of catalysts; 2) Selective activation and directed conversion of carbon-based energy-carrying molecules at the interface; 3) Interaction mechanism and regulation of catalyst solid surface interface properties under environment and external field. This book will be useful for researchers and students who are interested in carbon-based nanomaterials, electrochemical catalysts and energy storage.
The book presents the various ways in which persuasion can be used to make people behave in certain ways without coercion, intimidation, or brute force. It explores the intricacies of social influence processes like self-presentation, impression management, ingratiation, persuasion, manipulative social behavior, and compliance in socio-cultural contexts. Social influence constitutes one of the key themes in the field of social psychology. Contributions in the book highlight social influence behavior and its importance in human social life. The book deepens the reader's understanding of social psychology research on the science and applications of social influence. It invites readers to consider critical questions, such as the interactive effects of personality/disposition and situational factors on social influence. Given its scope, the book is of interest to those in academic fields like social psychology, political science, mass communication, and marketing.
This book describes the practical application of artificial intelligence (AI) methods using time series data in system control. This book consistently discusses the application of machine learning to the analysis and modelling of time series data of physical quantities to be controlled in the field of system control.Since dynamic systems are not stable steady states but changing transient states, the changing transient states depend on the state history before the change. In other words, it is essential to predict the change from the present to the future based on the time history of each variable in the target system, and to manipulate the system to achieve the desired change. In short, time series is the key to the application of AI machine learning to system control. This is the philosophy of this book: "e;time series data"e; + "e;AI machine learning"e; = "e;new practical control methods"e;.This book can give my helps to undergradate or graduate students, institute researchers and senior engineers whose scientific background are engineering, mathematics, physics and other natural sciences.
This volume discusses the relevance of different ergonomic principles in fashion, lifestyle, and accessory design. Written in a simple and concise language, the book makes the subject interesting to those unfamiliar with the technicalities in ergonomics. The contents provide a broad overview of the relevance of ergonomics in fashion design, and touches upon the systems aspects of ergonomics in fashion design. It also includes ergonomic issues like dimensions, adornment of different body parts, thermoregulation through clothing. The volume highlights the application of ergonomics in different domains of fashion (sports, medicine, etc) followed by ergonomic issues in fashion designing for elderly and the disabled. Ergonomic issues in fashion design for different context like crowded places, mass transportation etc are also discussed. This volume will be of interest to those in academia and industry alike.
This book provides an overview of bidirectional communication between gut-microbiome-brain, pathways, nutrients, and metabolites that are involved in microbiota gut-brain axis (MGBA) interactions. Further it reviews the relevance of this axis in the neurological disorders and potential therapeutic interventions, involving gut microbiome or probiotics and prebiotics which can ameliorate the neurological disorders. The book examines the role of gut microbiota in the establishment and hemostasis of innate immune response and explores the possibility of development of microbiome-targeted therapeutic interventions. Notably, the book discusses the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. It also highlights the recent advances in improving neurological diseases by phytochemicals, prebiotics and probiotics. This book is useful for researchers working in neuropharmacology, Clinical Research, toxicology, neurodegeneration, and stroke biology.
This book provides a concise history of economic thought for readers of all ages. While some basic economics knowledge would be helpful, it is not required. The book sets out to achieve three aims: to be interesting, entertaining, and thought-provoking. While the authors may appear opinionated in certain instances, this is intentionally done in order to alert readers to form their own views. History of ideas does not make the us smarter nor richer, but it can reduce our ignorance and the "e;banality of evil"e;-a term Hannah Arendt referred to people who lack self-reflection, "e;He did his duty...; he not only obeyed orders, he also obeyed the law."e;