Bøger udgivet af Springer New York

The field of capillary-tissue exchange physiology has been galvanized twice in the past 25 years. A 1969 conference at the National Academy of Sciences in Copenhagen resulted in the book Capillary Permeability: The Transfer of Mole­ cules and Ions Between the Capillary Blood and the Tissue (Crone and Lassen, 1970). It focused on the physiochemical aspects of transcapillary water and solute transport. The field has matured considerably since. This volume was designed as the successor to the 1970 book, and was created at a gathering of the authors at McGill University. It too captures the breadth of a field that has been dramatically enriched by numerous technical and conceptual advances. In 1970 it was already known that the capillary wall was not merely a "cellophane bag" exerting steric hindrances on solute particles. Instead, the endothelial surface was recognized as the site of binding reactions and permeation by passive or carrier-mediated trans­ port. Furthermore, the cells of the blood could traverse evanescent wide openings in the "zippered" clefts. Today, research priorities have turned more to cell-cell interactions, toward understanding the utility of the gap junctional connections between endothelial cells and neighboring smooth muscle cells, neuronal twigs, and the parenchymal cells of organs. New discoveries in the past few years have revealed the critical importance of the close relationships between the endothelial cells and the parenchymal cells.

1 Lebensmittelüberwachung.- 1.1. Reasons for initiating the work.- 1.1 Geschichtliches.- 1.2 Grundlagen des heutigen Lebensmittelrechts.- 1.3 Grundsätze der Überwachung.- 1.4 Zuständigkeiten und Organisation der Lebensmittelüberwachung in den einzelnen Bundesländern.- 1.5 Durchführung der Überwachung.- 1.5.1 Sorgfaltspflicht der Hersteller.- 1.5.2 Amtliche Überwachung.- 1.5.3 Überwachungsbeamte.- 1.5.4 Zusammenarbeit der an der Überwachung beteiligten Personen.- 1.6 Betriebskontrolle.- 1.7 Entnahme von Proben.- 1.7.1 Zahl und Auswahl der Proben.- 1.7.2 Planprobe.- 1.7.3 Verdachtsprobe.- 1.7.4 Beschwerdeprobe.- 1.7.5 Vergleichsprobe.- 1.7.6 Gegenprobe.- 1.7.7 Proben für Monitoring-Programme.- 1.8 Untersuchung und Gutachten.- 1.8.1 Organisation und Ausstattung der Laboratorien.- 1.8.2 Untersuchungen.- 1.8.3 Untersuchungen unter Berücksichtigung der europäischen Normen EN 45001 bis 45003 und der guten Laborpraxis.- 1.8.4 Gutachten.- 1.9 Maßnahmen der Überwachung.- 1.9.1 Freiwillige Maßnahmen der Betroffenen.- 1.9.2 Anordnungen.- 1.9.3 Beschlagnahme, Sicherstellung.- 1.9.4 Warnung und Information der Öffentlichkeit.- 1.10 Literatur.- 2 Industrielle Qualitätssicherung.- 2.1 Was ist Qualität?.- 2.2 Die Erwartung des Kunden.- 2.3 Qualitätssicherung.- 2.3.1 Historie der Qualitätssicherung.- 2.3.2 Präventives Qualitätsmanagement.- 2.3.3 Aufbau einer Qualitätssicherungsabteilung.- 2.4 Die Instrumente der Qualitätssicherung.- 2.4.1 Qualitätspolitik.- 2.4.2 Briefing und Umsetzung.- 2.4.3 Lebensmittelrechtliche Aspekte.- 2.4.4 Rohwaren-und Packmittelspezifikation.- 2.4.5 Lieferantenaudit.- 2.4.6 Kontrollierte Erzeugung.- 2.4.7 Rohwareneingang.- 2.4.8 Bau-und Anlagendesign.- 2.4.9 Rezeptur-und Herstellanweisung.- 2.4.10 HACCP.- 2.4.11 Quality Monitoring.- 2.4.12 Good Laboratory Practice.- 2.4.13 Good Manufacturing Practice.- 2.4.14 Fertigwarenspezifikation.- 2.4.15 Lager-und Versandanweisungen.- 2.4.16 Loskennzeichnung.- 2.4.17 Warenrückrufsystem und Krisenmanagement.- 2.4.18 Dokumentationssystem und Archivierung.- 2.4.19 Übergeordnete QS-Maßnahmen.- 2.4.20 Qualitätskosten.- 2.4.21 Industrial Organisation und Controlling.- 2.5 Personalqualifikation.- 2.6 Zertifizierung von QS-Systemen.- 2.7 Amtliche Lebensmittelüberwachung.- 2.8 Total Quality Management.- 2.9 Literatur.- 3 Lebensmittelrecht und EG.- 3.1 Einführung.- 3.1.1 Die Europäische Gemeinschaft und ihre Rechtsordnung.- 3.1.2 Die Organe der Europäischen Gemeinschaft.- 3.2 EWG-Vertrag und Einheitliche Europäische Akte - Bestimmungen, die für das Lebensmittelrecht von Bedeutung sind.- 3.3 Rechtssetzung in der Europäischen Wirtschaftsgemeinschaft.- 3.3.1 Rechtssetzungsmaßnahmen.- 3.3.2 Rechtssetzungsverfahren.- 3.4 EG-Lebensmittelrecht und für den Verbraucherschutz bedeutsame Regelungen im EG-Agrarrecht.- 3.4.1 EWG-Verordnungen.- 3.4.2 EWG-Richtlinien.- 3.4.2.1 Horizontale EWG-Richtlinien.- 3.4.2.2 Vertikale EWG-Richtlinien.- 3.4.3 Entscheidungen des Europäischen Gerichtshofes.- 3.4.4 Neuer Ansatz der Kommission im gemeinschaftlichen Lebensmittelrecht.- 3.5 Ausschüsse der Kommission und ihre Aufgaben.- 3.5.1 Wissenschaftlicher Lebensmittelausschuß.- 3.5.2 Beratender Lebensmittelausschuß.- 3.5.3 Weitere Ausschüsse bei der Kommission mit Bedeutung für den Lebensmittelbereich.- 3.6 Prinzipien der Lebensmittelüberwachung in der EG.- 3.7 Literatur.- 4 Lebensmittelbedarfsgegenstände.- 4.1 Warengruppen.- 4.2 Beurteilungsgrundlagen.- 4.2.1 Deutsche Rechtsvorschriften.- 4.2.2 Richtlinien der EG.- 4.2.3 Standardisierung von Prüfverfahren.- 4.2.4 Empfehlungen des Bundesgesundheitsamtes.- 4.3 Warenkunde.- 4.3.1 Metalle.- 4.3.1.1 Aluminium.- 4.3.1.2 Nichtrostende Stähle.- 4.3.1.3 Zinn.- 4.3.1.4 Sonstige Werkstoffe aus Metall.- 4.3.2 Silikatische Materialien.- 4.3.2.1 Glas.- 4.3.2.2 Keramik.- 4.3.2.3 Email.- 4.3.2.4 Übergang von Inhaltsstoffen.- 4.3.3 Papier, Karton und Pappe.- 4.3.3.1 Definitionen.- 4.3.3.2 Papierherstellung.- 4.3.4 Kautschuk und Elas

This second edition book advances knowledge about criminal careers throughout life. It presents new results from the Cambridge Study in Delinquent Development (CSDD), which is a unique longitudinal study of the development of offending from age 10 to age 61. Previous results obtained in the CSDD are reviewed, and then new findings from official criminal records up to age 61 are presented: on offending at different ages, continuity in offending, ages of onset, and criminal career duration. The number of offenders and offenses between ages 50 and 61 is noteworthy. The book then presents results on self-reported offending in different age ranges up to 48: on prevalence, frequency, continuity, and comparisons with official records that suggest that official records only capture the tip of the iceberg of offending. It then analyzes different trajectories of official offending up to age 61 and shows to what extent they could be predicted by childhood risk factors. New results from the CSDD in the last 10 years are then presented, followed by a discussion of the relevance of all the findings for criminological theories and public policies such as early intervention. This book should be of great interest not only to academics but also to policy makers and practitioners who are concerned with crime. . . . . . . . . . . . . . . . .

This volume focuses on games to manage and facilitate rehabilitation. It emphasizes user practice, attitudes, and experience, and their changing place within developing rehabilitation frameworks. It looks at how users have adopted, integrated, and innovated with games to facilitate rehabilitation. Topics include game technology, game design and accessibility, web-based technologies vs pervasive and mobile technologies, social and collaborative aspects, and rehabilitative outcome. Games for rehabilitation are gaining interest from different communities such as medicine, psychology, and rehabilitation. A distinction can be made between games specifically made for rehabilitative purposes and games made for the general public but that are used in rehabilitation as well. Games have allowed the building of new/complementary forms for rehabilitation and offered new options to produce rehabilitative activities and experiences.

The present volume supersedes my Introduction to Differentiable Manifolds written a few years back. I have expanded the book considerably, including things like the Lie derivative, and especially the basic integration theory of differential forms, with Stokes' theorem and its various special formulations in different contexts. The foreword which I wrote in the earlier book is still quite valid and needs only slight extension here. Between advanced calculus and the three great differential theories (differential topology, differential geometry, ordinary differential equations), there lies a no-man's-land for which there exists no systematic exposition in the literature. It is the purpose of this book to fill the gap. The three differential theories are by no means independent of each other, but proceed according to their own flavor. In differential topology, one studies for instance homotopy classes of maps and the possibility of finding suitable differentiable maps in them (immersions, embeddings, isomorphisms, etc.). One may also use differentiable structures on topological manifolds to determine the topological structure of the manifold (e.g. it la Smale [26]).

"e;The appearance of Grunbaum's book Convex Polytopes in 1967 was a moment of grace to geometers and combinatorialists. The special spirit of the book is very much alive even in those chapters where the book's immense influence made them quickly obsolete. Some other chapters promise beautiful unexplored land for future research. The appearance of the new edition is going to be another moment of grace. Kaibel, Klee and Ziegler were able to update the convex polytope saga in a clear, accurate, lively, and inspired way."e; (Gil Kalai, The Hebrew University of Jerusalem) "e;The original book of Grnbaum has provided the central reference for work in this active area of mathematics for the past 35 years...I first consulted this book as a graduate student in 1967; yet, even today, I am surprised again and again by what I find there. It is an amazingly complete reference for work on this subject up to that time and continues to be a major influence on research to this day."e; (Louis J. Billera, Cornell University) "e;The original edition of Convex Polytopes inspired a whole generation of grateful workers in polytope theory. Without it, it is doubtful whether many of the subsequent advances in the subject would have been made. The many seeds it sowed have since grown into healthy trees, with vigorous branches and luxuriant foliage. It is good to see it in print once again."e; (Peter McMullen, University College London)

Glutamine is the most abundant amino acid and is a major contributor to whole body nitrogen metabolism and is considered to be ¿conditionally essential.¿ Glutamine in Health and Disease presents the application of current nutritional knowledge by physicians and dietitians and incorporates emerging fields of science and important discoveries. Section 1 covers glutamine structure and function, glutamine synthetase, glutamine binding protein, glutamine transport, glutamine-rich activation domains and transcription, glutamine transaminase and cell biochemistry. Section 2 covers glucose-independent glutamine metabolism, intestinal barrier function, thyroid-stimulating hormone, glutamine resonances, focal ischemia, plasma glutamine, metabolic stress, cancer and absorption. Section 3 covers dipeptide-bound glutamine, DNA protection, oxidative stress, NF-KB, the inflammatory response, the lung, kidney, GI tract and liver, autophagy, ethanol and diabetes. Finally, Section 4 covers the use of glutamine in preoperative states, enteral and parenteral nutrition, pulmonary infections, cancer, hypoxic injury, arginyl-glutamine, paediatrics, pancreatic surgery, the elderly, gastric emptying gastric bypass and use glutamine cocktails. Written by authors of international and national standing, leaders in the field and trendsetters, Glutamine in Health and Disease is essential reading for nutritionists and dietitians, public health scientists, physicians, epidemiologists, policy makers, and health care professionals of various disciplines.

Since information in the brain is processed by the exchange of spikes among neurons, a study of such group dynamics is extremely important in understanding hippocampus dependent memory. These spike patterns and local field potentials (LFPs) have been analyzed by various statistical methods. These studies have led to important findings of memory information processing. For example, memory-trace replay, a reactivation of behaviorally induced neural patterns during subsequent sleep, has been suggested to play an important role in memory consolidation. It has also been suggested that a ripple/sharp wave event (one of the characteristics of LFPs in the hippocampus) and spiking activity in the cortex have a specific relationship that may facilitate the consolidation of hippocampal dependent memory from the hippocampus to the cortex. The book will provide a state-of-the-art finding of memory information processing through the analysis of multi-neuronal data. The first half of the book is devoted to this analysis aspect. Understanding memory information representation and its consolidation, however, cannot be achieved only by analyzing the data. It is extremely important to construct a computational model to seek an underlying mathematical principle. In other words, an entire picture of hippocampus dependent memory system would be elucidated through close collaboration among experiments, data analysis, and computational modeling. Not only does computational modeling benefit the data analysis of multi-electrode recordings, but it also provides useful insight for future experiments and analyses. The second half of the book will be devoted to the computational modeling of hippocampus-dependent memory.

This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others.Written by world-renowned scientists in the field, Neural Stem Cells in Development, Adulthood and Disease presents cutting-edge studies of interest to both established neurogenesis researchers and readers with general interests in nervous system science. It is an authoritative addition to the Stem Cell Biology and Regenerative Medicine series.

Treatment of Benign Prostatic Hyperplasia: Modern Techniques is an up-to-date review of modern techniques used to treat benign prostatic hyperplasia. It provides a comprehensive review of both office and operating room based techniques. Both electrosurgical and laser based techniques are covered. These include high powered 532 nm laser photoselective laser vaporization of the prostate (PVP), holmium laser enucleation/ablation of the prostate (HoLEP/HoLAP), and Bipolar Electrovaporization of the Prostate (Bipolar EVP/Bipolar TURP). In addition, a comprehensive review of office based techniques and future therapies currently being developed is presented. Each of these techniques are presented in a balanced fashion with a focus on modern literature. Treatment of Benign Prostatic Hyperplasia: Modern Techniques will be of great value to Urologists, Urology Residents, Iternists, and Family Practitioners. ¿

This is a timely and informative updated edition for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, this updated title is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current treatment issues and strategies for both adults and children. While several of the chapters are no longer relevant from the first edition, other topics have emerged as interesting and current. This edition will keep the two-section format of Physiology and Pathophysiology and Clinical Management, but it increases the first section to 10 chapters and reduces the second section to 12 chapters. The plan is to keep this edition in the range of about 350 to 400, maximum, printed pages. The volume is again divided into two parts. Part 1 covers new discoveries in the physiological control of body weight, as well as the pathophysiology of obesity. Expert authors discuss pathways that control food intake, energy expenditure and peripheral nutrient metabolism, including a look at the emerging evidence of the role of adipose tissue as an endocrine organ. Part 2 covers all the key issues central to clinical management, including recent developments in the epidemiology of obesity, assessment of the obese patient, behavioral strategies in weight management, dietary modification as a weight management strategy, physical activity as a weight management strategy, weight loss drugs, surgical approaches to obesity and other important clinical topics. An essential, practical text that sorts, synthesizes and interprets the latest information on obesity-related topics, this second edition will be an essential resource for clinical endocrinologists and other health care providers across a broad spectrum of specialties.

¿¿Non-parametric methods are widely used for studying populations that take on a ranked order (such as movie reviews receiving one to four stars). The use of non-parametric methods may be necessary when data have a ranking but no clear numerical interpretation, such as when assessing preferences. In terms of levels of measurement, non-parametric methods result in "ordinal" data. As non-parametric methods make fewer assumptions, their applicability is much wider than the corresponding parametric methods. In particular, they may be applied in situations where less is known about the application in question. Also, due to the reliance on fewer assumptions, non-parametric methods are more robust. Non-parametric methods have many popular applications, and are widely used in research in the fields of the behavioral sciences and biomedicine. This is a textbook on non-parametric statistics for applied research. The authors propose to use a realistic yet mostly fictional situation and series of dialogues to illustrate in detail the statistical processes required to complete data analysis. This book draws on a readers existing elementary knowledge of statistical analyses to broaden his/her research capabilities. The material within the book is covered in such a way that someone with a very limited knowledge of statistics would be able to read and understand the concepts detailed in the text.The ¿real world¿ scenario to be presented involves a multidisciplinary team of behavioral, medical, crime analysis, and policy analysis professionals work together to answer specific empirical questions regarding real-world applied problems. The reader is introduced to the team and the data set, and through the course of the text follows the team as they progress through the decision making process of narrowing the data and the research questions to answer the applied problem. In this way, abstract statistical concepts are translated into concrete and specific language.This text uses one data set from which all examples are taken. This is radically different from other statistics books which provide a varied array of examples and data sets. Using only one data set facilitates reader-directed teaching and learning by providing multiple research questions which are integrated rather than using disparate examples and completely unrelated research questions and data.

The study of quantum disorder has generated considerable research activity in mathematics and physics over past 40 years. While single-particle models have been extensively studied at a rigorous mathematical level, little was known about systems of several interacting particles, let alone systems with positive spatial particle density. Creating a consistent theory of disorder in multi-particle quantum systems is an important and challenging problem that largely remains open. Multi-scale Analysis for Random Quantum Systems with Interaction  presents the progress that had been recently achieved in this area.  The main focus of the book is on a rigorous derivation of the multi-particle localization in a strong random external potential field. To make the presentation accessible to a wider audience, the authors restrict attention to a relatively simple tight-binding Anderson model on a cubic lattice Zd.  This book includes the following cutting-edge features: an introduction to the state-of-the-art single-particle localization theory an extensive discussion of relevant technical aspects of the localization theorya thorough comparison of the multi-particle model with its single-particle counterpart a self-contained rigorous derivation of both spectral and dynamical localization in the multi-particle tight-binding Anderson model.  Required mathematical background for the book includes a knowledge of functional calculus, spectral theory (essentially reduced to the case of finite matrices) and basic probability theory. This is an excellent text for a year-long graduate course or seminar in mathematical physics. It also can serve as a standard reference for specialists.

¿In this brief we consider some stochastic models that may be used to study problems related to environmental matters, in particular, air pollution.  The impact of exposure to air pollutants on people's health is a very clear and well documented subject. Therefore, it is very important to obtain ways to predict or explain the behaviour of pollutants in general. Depending on the type of question that one is interested in answering, there are several of ways studying that problem. Among them we may quote, analysis of the time series of the pollutants' measurements, analysis of the information obtained directly from the data, for instance, daily, weekly or monthly averages and standard deviations. Another way to study the behaviour of pollutants in general is through mathematical models. In the mathematical framework we may have for instance deterministic or stochastic models. The type of models that we are going to consider in this brief are the stochastic ones.¿

This text presents a comprehensive and concise evidence-based and differential-based approach to physical examination of the shoulder in a manner that promotes its successful application in clinical practice. Additionally, this book provides an integrated approach to the diagnosis of numerous shoulder pathologies by combining discussions of pathoanatomy and the interpretation of physical examination techniques and was written for any health care professional or student who may be required to evaluate patients who present with shoulder pain. This information will allow the clinician to make informed decisions regarding further testing procedures, imaging and potential therapeutic options.Physical Examination of the Shoulder will serve as an invaluable resource for practicing orthopedic surgeons, sports medicine specialists, physical therapists, residents in training and medical students interested in the field of clinical orthopedics. ¿

This book presents the current trends and practices in breast imaging. Topics include mammographic interpretation; breast ultrasound; breast MRI; management of the symptomatic breast in young, pregnant and lactating women; breast intervention with imaging pathological correlation; the postoperative breast and current and emerging technologies in breast imaging. It emphasizes the importance of fostering a multidisciplinary approach in the diagnosis and treatment of breast diseases. Featuring more than 800 high-resolution images and showcasing contributions from leading authorities in the screening, diagnosis and management of the breast cancer patient, Breast Cancer Screening and Diagnosis is a valuable resource for radiologists, oncologists and surgeons.

Facebook's psychological experiments and Edward Snowden's NSA leaks epitomize a world of increasing information awareness in the social media ecosystem. With over a billion monthly active users, Facebook as a nation is overtaking China as the largest country in the world. President Barack Obama, in his 2011 State of the Union Address, called America "e;the nation of Edison and the Wright brothers"e; and "e;of Google and Facebook."e; U.S. Chief Information Officer Steven VanRoekel opines that America has become a "e;Facebook nation"e; that demands increased transparency and interactivity from the federal government.Ubiquitous social networks such as Facebook, Google+, Twitter, and YouTube are creating the technologies, infrastructures, and big data necessary for Total Information Awareness - a controversial surveillance program proposed by DARPA after the 9/11 attacks. NSA's secret PRISM program has reinvigorated WikiLeaks founder Julian Assange's accusation that "e;Facebook is the most appalling spying machine that has ever been invented."e;Facebook CEO Mark Zuckerberg once said, "e;We exist at the intersection of technology and social issues."e; This book offers discourse and practical advice on the privacy issue in the age of big data, business intelligence in social media, e-government and e-activism, as well as personal total information awareness. This expanded edition also includes insights from Wikipedian Emily Temple-Wood and Facebook ROI experts Dennis Yu and Alex Houg.

Pediatric Urology: Evidence for Optimal Patient Management provides pediatric urologists the information needed for state-of-the-art patient care. Chapters are organized around pertinent clinical questions within major areas of pediatric urology, answered using the best available data while also reporting areas for which there is poor evidence. The text includes randomized controlled trials and prospective observational studies, tables that summarize important studies, and figures that illustrate algorithms with best options for management and their expected results. With an easy to use format not found in other volumes, Pediatric Urology: Evidence for Optimal Patient Management is an indispensible and unique resource for experienced pediatric urologists, pediatric surgeons, general urologists with an interest in pediatric urology, as well as fellows and residents in training.