Pathophilosophy of Human Disease ¿ New Viral Pandemics - Ravikumar Kurup - Bog

Modern civilization results in stress in societies leading to increased activation of the HPA axis leading to increased secretion of stress hormones the catecholamines producing increase in sympathetic tone. The increase in sympathetic tone leads to increase in stress hormones epinephrine and norepinephrine producing breeching of the gut blood barrier. This leads to decrease in mucin secretion lining the gut wall and inflammatory changes in the colonic mucosa. Modern civilization results in changes in dietary habits leading to less consumption of fibre and more intake of protein and fat. This leads to increased colonic archaeal growth and archaeal endosymbiosis. This produces a new human phenotype with increased predilection for new emerging viral pandemics and other civilizational disorders. The endosymbiotic archaeal growth leads to secretion of RNA viroids which are converted to DNA viroids by reverse transcriptase and integrated into the genome by integrase. The RNA viroids and their corresponding DNA viroids can recombine with human genomic sequences and other viruses generating new viruses.