Progress in Iron Research - Chaim Hershko - Bog

1) Mechanism of Fe(II) Oxidation and Core Formation in Ferritin.- 2) Chemico-Physical and Functional Differences Between H and L Chains of Human Ferritin.- 3) Iron Oxidation in Sheep, Horse and Recombinant Human Apoferritins.- 4) The Transferrin Receptor and the Release of Iron from Transferrin.- 5) The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages.- 6) Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition.- 7) Mechanism of Production of the Serum Transferrin Receptor.- 8) Iron Absorption and Cellular Uptake of Iron.- 9) Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.- 10) Cellular Responses to Iron and Iron Compounds.- 11) The Structure and Function of Iron Regulatory Factor.- 12) Structure and Function of IREs, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase.- 13) Translational Control by Iron-Responsive Elements.- 14) The Role of Cytokines in the Regulation of Ferritin Expression.- 15) Stimulation of IRE-BP Activity of IREF by Tetrahydrobiopterin and Cytokine Dependent Induction of Nitric Oxide Synthase.- 16) Reciprocal Modulation of Aconitase Activity and RNA-binding Activity of Iron Regulatory Factor by Nitric Oxide.- 17) A New Look at Ferritin Metabolism.- 18) Bacterioferritin: A Hemoprotein Member of the Ferritin Family.- 19) Intracellular Iron.- 20) Distinct Features of Iron Metabolism in Erythroid Cells: Implications for Heme Synthesis Regulation.- 21) Cellular Ferritin Uptake: A Highly Regulated Pathway for Iron Assimilation in Human Erythroid Precursor Cells.- 22) Differential Effects of Iron and Iron Carrier on Hematopoietic Cell Differentiation and Human ADA Gene Transfer.- 23) A Hemin-Inducible Enhancer Lies 4. 5 Kb Upstream of the Mouse Ferritin H Subunit Gene.- 24) Iron Deficiency: The Global Perspective.- 25) Iron Regulation in the Brain at the Cell and Molecular Level.- 26) Pathophysiology of Iron Toxicity.- 27) Morphologic Observations in Iron Overload: An Update.- 28) Identification of Thiolic Sarcolemmal Proteins as a Primary Target of Iron Toxicity in Cultured Heart Cells.- 29) Iron Overload and the Biliary Route.- 30) Changing Concepts of Haemochromatosis.- 31) Epidemiology, Clinical Spectrum and Prognosis of Hemochromatosis.- 32) The Morbidity of Hemochromatosis Among Clinically Unselected Homozygotes: Preliminary Report.- 33) Genetics of Haemochromatosis.- 34) Localization of Seven New Genes Around the HLA-A Locus.- 35) Searching for the Hemochromatosis Grail.- 36) Iron Chelator Design.- 37) Results from a Phase I Clinical Trial of HBED.- 38) Lessons from Preclinical and Clinical Studies with 1,2-Diethyl-3-Hydroxypyridin-4-One, CP94 and Related Compounds.- 39) Iron Chelation Therapy for Malaria.- 40) The Biochemical Basis for the Selective Antimalarial Action of Iron Chelators on Plasmodium Falciparum Parasitized Cells.