Strychnos spinosa and high blood pressure - Yvanna Temasoa - Bog

The aim of the present study is to valorize the use in traditional medicine of Strychnos spinosa (Loganiaceae) as an antihypertensive plant. On isolated rat aorta pre-contacted with phenilephrine the crude extract of the plant causes endothelium-dependent vasorelaxation with a relaxation EC50 value equal to 0.900 ± 0.054 mg/ml. L-NAME inhibits the vasorelaxation effect induced by the extract of Strychnos spinosa with an increase in EC50 value of 2.254± 0.140mg/ml, this shows that the vasorelaxation effect involves a mechanism that involves NO. The inhibition of the effect by propranolol, with an EC50 of 2.762±0.138mg/ml demonstrates that the vasorelaxant effect involves the participation of ¿2 adrenergic receptors.