Bøger i Advances in Inclusion Science serien

The rapidly growing number of papers and patents on Cyclodextrins and their potential or actual industrial uses raised the idea to organize a Symposium on Cyclodextrins.

Proceedings of the Third International Symposium on Clathrate Compounds and Molecular Inclusion Phenomena and the Second International Symposium on Cyclodextrins, Tokyo, Japan, July 23-27, 1984

Proceedings of the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins, Lancaster, UK, July 20-25, 1986

Charlie's academic experiences, his employment with du Pont, and the creative spark which he manifested at an early stage of his scientific career are detailed in the paper in this issue by Herman Schroeder. The field of macrocyclic chemistry, to a large degree, had its beginnings with Charlie's discovery.

The rapidly growing number of papers and patents on Cyclodextrins and their potential or actual industrial uses raised the idea to organize a Symposium on Cyclodextrins.

Proceedings of the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins, Lancaster, UK, July 20-25, 1986

Molecular biology has now advanced to the point where it is no longer possible to give a complete review of the available data on the conformational features of proteins. Such an analysis may result in one of three possible situations: neither the experi mental results nor their interpretation contradict the proposed model;

Proceedings of the Third International Symposium on Clathrate Compounds and Molecular Inclusion Phenomena and the Second International Symposium on Cyclodextrins, Tokyo, Japan, July 23-27, 1984

Cyclodextrins are galnlng industrial interest owing to their particu­ lar structure. These cyclic amyloses are commonly composed of 6, 7 or 8 (named a-, 8-, y-CD) glucose units. They undergo complexation with quite a large number of substances by molecular inclusion. Their potential for in­ dustrial application is substantiated by their ability to protect fragile substances from oxygen and UV, to delay the evolution of volatiles and to aid the ancillary processing of dangerous or volatile substances in powder­ ed form. Though a-, 8- and y-CD exhibit different inclusion specificity, 8-CD has found more attention than the others. This is due to the fact that most of the cyclodextrin producing enzymes known produce predominantly 8-CD. Fur­ thermore 8-CD is by far the least soluble form, leading to a relatively sim­ ple production and purification. Consequently 8-CD is already in production on an industrial scale [~] while a- and 8-CD are still more or less re­ garded as specialities. A further CD-producing enzyme has been found in the medium of K. pneu­ moniae [l], Since this CGT appeared to produce predominantly a-CD [~], it has been chosen to develop a process for the production of a-CD. MATERIALS AND METHODS Analysis of cyclodextrins: HPLC on Lichrosorb-NH . 10 ~m, with acetonitrile 2 water 65/35 per volume. Test for CGT activity: as described by Landert elsewhere in this Volume. Starch: potato starch as obtained from Blattmann, Wadenswil, Switzerland.