Bøger i De Gruyter Series in Mathematics and Life Sciences serien

Electroencephalography and magnetoencephalography are the two most efficient techniques to study the functional brain. This book completely aswers the fundamental mathematical question of uniqueness of the representations obtained using these techniques, and also covers many other concrete results for special geometric models of the brain, presenting the research of the authors and their groups in the last two decades.

This monograph discusses statistics and risk estimates applied to radiation damage under the presence of measurement errors. The first part covers nonlinear measurement error models, with a particular emphasis on efficiency of regression parameter estimators. In the second part, risk estimation in models with measurement errors is considered. Efficiency of the methods presented is verified using data from radio-epidemiological studies. Contents: Part I - Estimation in regression models with errors in covariatesMeasurement error modelsLinear models with classical errorPolynomial regression with known variance of classical errorNonlinear and generalized linear models Part II Radiation risk estimation under uncertainty in exposure dosesOverview of risk models realized in program package EPICUREEstimation of radiation risk under classical or Berkson multiplicative error in exposure dosesRadiation risk estimation for persons exposed by radioiodine as a result of the Chornobyl accidentElements of estimating equations theoryConsistency of efficient methodsEfficient SIMEX method as a combination of the SIMEX method and the corrected score methodApplication of regression calibration in the model with additive error in exposure doses

The book provides a unique collection of in-depth mathematical, statistical, and modeling methods and techniques for life sciences, as well as their applications in a number of areas within life sciences. The book provides also with a range of new ideas that represent emerging frontiers in life sciences where the application of such quantitative methods and techniques is becoming increasingly important. Many areas within life sciences are becoming increasingly quantitative and the progress in those areas will be more and more dependent on the successful development of advanced mathematical, statistical and modelling methodologies and techniques. The state-of-the-art developments in such methodologies and techniques are scattered throughout research journals and hardly accessible to the practitioners in those areas. This book identifies a number of frontier areas where such methodologies and techniques have recently been developed and are to be published here for the first time, bringing substantial potential benefit to a range of applications in life sciences. In addition, the book contains several state-of-the-art surveys at the interface of mathematics and life sciences that would benefit a larger interdisciplinary community. It is aimed at researchers in academia, practitioners and graduate students who want to foster interdisciplinary collaborations required to meet the challenges at the interface of modern life sciences and mathematics.

This book focuses on the dynamic complexity of neural, genetic networks, and reaction diffusion systems. The author shows that all robust attractors can be realized in dynamics of such systems. In particular, a positive solution of the Ruelle-Takens hypothesis for on chaos existence for large class of reaction-diffusion systems is given. The book considers viability problems for such systems - viability under extreme random perturbations - and discusses an interesting hypothesis of M. Gromov and A. Carbone on biological evolution. There appears a connection with the Kolmogorov complexity theory. As applications, transcription-factors-microRNA networks are considered, patterning in biology, a new approach to estimate the computational power of neural and genetic networks, social and economical networks, and a connection with the hard combinatorial problems.

This two-volume work focuses on the mathematical aspects of Darwinian evolution starting from the basic model of asexual stochastic evolution of a single isolated locus in the presence of mutation. Vol. 2 discusses fitness landscape, genealogy and various mathematical applications to virus evolution. Vol. 1: One-Locus and Multi-Locus Theory and Recombination.