Bøger i Ernst Schering Foundation Symposium Proceedings serien

The aim of the Ernst Schering Research Foundation Workshop 29 was to discuss the contribution of research on model organisms which are particularly suited for genetic and biological research, to the understanding of gen eral principles of biology as well as the basis for human diseases.

Presents the advances in stem cell research. This book discusses the analysis and use of stem cells in basic biology, and their application in clinical practice.

The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process.

Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged.

Leading scientists from Europe and North America were invited to discuss computer-aided drug design in industrial research. These changes are gaining momentum, so it is the right time to think about the role of computer-aided drug design in this changing environment.

Bone is a sex hormone-dependent organ, which has importantimplications for current therapeutic strategies in theprevention and possible treatment of bone loss in theelderly.

In February 2001, two separate teams published the first working drafts of the entire human genome, marking an achievement that is certainly one of the seminal developments in our understanding of human biology.

The European Workshops on Molecular and Cellular Endocrinology of the Testis have become by now a well-established tradition. Together with the Miniposter book they constitute an excel lent written account of the Proceedings of the 8th European Testis Workshop.

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands.

Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur bid.

The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop.

This book gives an updated review of the state of the art in regenerative cell therapy in the fields of cardiology, hematology, pediatrics, neurology, orthopedics and infectious diseases.

Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease.

Reasoning in terms of molecular recognition may be traced back to Emil Fischer, who practiced the art of chemistry at Humboldt University in Prussian Berlin a century ago.

In recent years the importance of adjuvants for optimising the activity of agrochemicals has become increasingly recognized. This book is aimed at accumulating the current knowledge of the interactions between adjuvants, agrochemicals and target organisms.

This book provides an excellent overview on state-of-the-art of modern organocatalysis. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.

In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged.

This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry.

This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry.

Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.

Introducing neuroinflammation and its involvement in human neurodegenerative disease, this text discusses the microglia and their response to brain injury, the importance of the chemokine family, experimental models of BSE, scrapie and vCJD as well as Alzheimer's disease, stroke and MS.

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands.

The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient.