Bøger i Reviews of Physiology, Biochemistry and Pharmacology serien

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

This is the first of three volumes in the "Ion Channels & Transporters in Tumor Biology" collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

ContentsH,-J. Apell: Structure -Function Relationship in P-Tyype ATPases - A Biophysical ApproachH. Koepsell, B. Schmitt, and V. Goboulev: Organic Cation TransportersW.G. Wier and K.G. Morgan:Alpha1-Adrenergic Signaling Mechanisms in Mammalian Resistance ArteriesG. Ahnert-Hilger, M. Höltje, I. Pahner, S. Winter and I. Brunk: Regulation of Vesicular Neurotransmitter Transporters

This third and final volume in the "e;Ion Transport in Tumor Biology"e; collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed. As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application.As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.