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Concerned with discovering the chemical pathways of biosynthesis, this book devotes four chapters to the use of isotopes in biosynthetic research and the biosynthesis of enzyme cofactors and vitamin B12 and of reduced polyketides such as erythromycin.

Isolated enzymes are known as useful for synthesising of complex molecules with more and more large scale applications in recent years.

The first review in this book presents synthetic strategies, biosynthesis and the genetics involved. The second review article, on non-template based multienzyme systems, addresses why polyketides are the most diverse group of natural products, comparing polyketide syntheses with other non-template multienzyme systems.

This volume recapitulates the state of the art in those sectors of bioorganic chemistry that, rather than mimick the natural example, aim to utilize the underlying principles for useful applications.

They cover the whole spectrum from the discovery of novel enzymes - by modern screening, evolutionary or immunological approaches - through immobilization techniques for technical processes, to their use in the asymmetric synthesis of important target compounds.

Whereas the hydrolases such as proteases, esterases and lipases are sufficiently well researched to be applied in every standard laboratory, other types of enzymes are still waiting to be discovered with respect to their applicability in organic-chemistry transformations on a preparative scale.

This book is unique in covering the present status and future potential of natural products in drug discovery.

The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres.

The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres.

Homogeneous catalysis is an important strategy for the synthesis of high-valued chemicals. Brandsma has carefully selected and checked the experimental procedures illustrating the catalytic use of copper, nickel, and palladium compounds in organic synthesis.

The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres.

This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientists at the forefront of this rapidly growing field.

"WHAT DOES NOT NEED TO BE BIG, WILL BE SMALL", a word by an engineer at a recent conference on chips technology. The engineering of micron and submicron sized features on the surface of silicon, glass and polymers opens a whole new world. An engineer, a chemist or a biologist will find new impulses from the various chapters in this book.

The synthesis of very complex saccharide structures is one of the most challenging areas of modern glycoscience. This volume presents the state of the art of complex carbohydrate synthesis, written by leading scientists whose groups are making major contributions in the field. Reflecting the particular interest in inhibitors and modulators as well as in mimetics, an in-cepth treatment is given both of their selective syntheses and of their biological implications. In addition the concept of multivalent glycoconjugate recognition as well as supramolecular implications of amphiphilic carbohydrates are highlighted.

This volume presents exciting new developments in preparative heterocyclic chemistry with a special emphasis on the stereoselective synthesis of - or with the aid of - heterocycles. A wide range of modern methods and strategies for the construction and synthetic elaboration of versatile heterocycles is surveyed in depth by leading researchers in this field. Due to the high quality and up-to-date coverage of each chapter, this volume provides a valuable overview of the different aspects discussed and will at the same time be highly inspiring for the expert synthetic organic chemist as well as the non-specialist reader.