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This book provides researchers in the fields of organic chemistry, organometallic chemistry and homogeneous catalysis with an overview of recent developments in the applications of reactions involving carbene and nitrene intermediates directed to the synthesis of heterocyclic compounds. Multiple pathways through which diverse heterocyclic compounds are accessed occur from a variety of carbene and nitrene precursors through C-H/X-H insertions, cycloadditions, ylide transformations, rearrangements, and cascade reactions. Catalytic processes that form metallo-carbenes and nitrenes offer unparalleled chemo-, regio-, and stereo-selectivities. Insights are provided into the scope of these methodologies and the inherent control of catalyst ligands on reaction selectivities.

This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability. In recent times, flow chemistry has heralded a paradigm shift in organic synthesis as it offers several unique advantages over conventional methods like drastic acceleration of sluggish transformations, enhanced yields, cleaner reactions etc and is gradually gaining a lot of attention among organic chemist worldwide. Given the importance of heterocycles in natural products, medicinal chemistry and pharmaceuticals, this is a well warranted volume and complements the previous volume of Topics in Organometallic Chemistry 'Organometallic Flow Chemistry'. This volume offers a versatile overview of the topic, besides discussing the recent progress in the flourishing area of flow chemistry in relevance to heterocyclic chemistry; it will also help researchers to better understand the chemistry behind these reactions. This in turn provides a platform for future innovations towards the designing of novel transformations under continuous flow. Thus, this volume will appeal to both the novices in this field as well as to experts in academia and industry.

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature and this book covers the hot topics of frontier research summarized by reputed scientists in the field.

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers this hot topic of frontier research summarized by reputed scientists in the field.

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature and this book covers the hot topics of frontier research summarized by reputed scientists in the field.

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Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers hot topics of frontier research summarized by reputed scientists in the field.

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature and this book covers the hot topics of frontier research summarized by reputed scientists in the field.

well-known authors, each an authority in his ?eld. The ?rst chapter is devoted to the use of oximes in cycloadditions which leads to formationof isoxazolines and isoxazolidines and from there to synthesis of macrolides like amphotericin and of other natural products and bioactive molecules. Furthermore, 4+2 cycloadditions of nitrosoalkenes are also included. This chapter complements the one in the X Preface previous volume which discussed access to isoxazolines via nitroalkanes.

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers this hot topic of frontier research summarized by reputed scientists in the field.

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature and this book covers the hot topics of frontier research summarized by reputed scientists in the field.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community.

This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability. In recent times, flow chemistry has heralded a paradigm shift in organic synthesis as it offers several unique advantages over conventional methods like drastic acceleration of sluggish transformations, enhanced yields, cleaner reactions etc and is gradually gaining a lot of attention among organic chemist worldwide. Given the importance of heterocycles in natural products, medicinal chemistry and pharmaceuticals, this is a well warranted volume and complements the previous volume of Topics in Organometallic Chemistry 'Organometallic Flow Chemistry'. This volume offers a versatile overview of the topic, besides discussing the recent progress in the flourishing area of flow chemistry in relevance to heterocyclic chemistry; it will also help researchers to better understand the chemistry behind these reactions. This in turn provides a platform for future innovations towards the designing of novel transformations under continuous flow. Thus, this volume will appeal to both the novices in this field as well as to experts in academia and industry.

Geraldine Masson, Luc Neuville Carine Bughin Aude Fayol Jieping ZhuMulticomponent Syntheses of MacrocyclesThomas J.J. MullerPalladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of HeterocyclesRachel Scheffelaar Eelco Ruijter Romano V.A.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community.

Aromaticity is a notion that appeared in the mid-nineteenth century to differentiate between unsaturated hydrocarbons and formally unsaturated benzene [1-3].

Geraldine Masson, Luc Neuville Carine Bughin Aude Fayol Jieping ZhuMulticomponent Syntheses of MacrocyclesThomas J.J. MullerPalladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of HeterocyclesRachel Scheffelaar Eelco Ruijter Romano V.A.

Banfi A. Basso R. Chebanov K. Gura S.M. Huang K. Khoury A. Elders E. Ruijter V.G. Nenajdenko R.V.A. Cukalovic J.-C.M.R. Monbaliu C.V. Wessjohann C.R.B. Rhoden D.G. Rivera O. del Mar Sanchez Duque C. Allais N. Isambert T. Constantieux J.

With contributions by numerous experts

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. This series covers hot topics of frontier research summarized by reputed scientists in the field.

N. Pemberton, E. Chorell, F. Almqvist: Microwave-Assisted Synthesis and Functionalization of 2-Pyridones, 2-Quinolones and other Ring-Fused 2-Pyridones.- M.C. Bagley, M.C. Lubinu: Microwave-Assisted Multicomponent Reactions for the Synthesis of Heterocycles.- T. Besson, V. Thiery: Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles M. Erdélyi: Solid-Phase Methods for the Microwave-Assisted Synthesis of Heterocycles.- S. Crosignani, B. Linclau: Synthesis of Heterocycles Using Polymer-Supported Reagents under Microwave Irradiation.- B.U.W. Maes: Transition Metal-Based Carbon-Carbon and Carbon-Heteroatom Bond Formation for the Synthesis and Decoration of Heterocycles.- M. Rodriquez and M. Taddei: Synthesis of Heterocycles via Microwave-Assisted Cycloadditions and Cyclocondensations.- N. Kaval, P. Appukkuttan, E. Van der Eycken: The Chemistry of 2-(1H)-Pyrazinones in Solution and on Solid Support