Udviklingsbiologi

Charles Darwins banebrydende værk som ligger til grund for al biologisk evolutionsteori.Når man læser Darwins bog, forbavses man over hans alsidighed, viden og kombinationsevne. Han er naturhistoriker af det helt store format og så kendte han store dele af jorden".Få andre bøger har skabt en sådan storm af kontroverser som Arternes Oprindelse. Darwins teori om, at arter stammer fra andre arter ved en gradvis evolutionær proces – og at gennemsnitsniveauet for hver art øges ud fra grundtanken om at – kun den bedst egnede overlever (”the survival of the fittest”), hvilket fik debatten til at tage nye højder. Den senere accept af Darwins teorier, revolutionerede det videnskabens forløb.Darwins bidrag til den moderne videnskab, er altafgørende for, hvordan vi ser verden i dag - og næsten umulig at evaluere. Arternes oprindelse bør læses af alle med interesse indenfor biologi og for verdens evolution. Ligesom bogen har bidraget til heftig debat og fortolkning indenfor områder som filosofi og teologi.Bogen regnes for det vigtigste bidrag til biologien i videnskabens historie.Den originale version af Darwins "Arternes Oprindelse" udgives af Paludans Forlag, hvor bogen indgår i serien blandt klassiske historiske værker.

THE INTERNATIONAL BESTSELLER: a deep dive into the science and nature of aging

Life is definitively purposive and creative. Organisms use genes in controlling their destiny. This book presents a new understanding of how living systems function, showing how organisms generate purposive behaviour. For general readers interested in evolutionary biology, systems biology, genetics, and history and philosophy of science.

Biolog og naturformidler Anders Kofoed fortæller i denne bog om det forunderlige dyr, som i eget billede er planetens allervigtigste: mennesket.Læs om alle stadierne i menneskedyrets tilværelse og om meningen med dem - hvis der altså er en! Vores historie begynder under dynen, ved undfangelsen, og slutter under jorden, når mennesket er gået bort, og det sidste liv ebber ud. Indimellem går Anders Kofoed bagom alle de andre store øjeblikke. Spædbarnet, der begynder at pludre og får sprog. Teenageren, der flipper ud på sine forældre. Kvinden, der føder i svære smerter og giver livet videre. Forældreparret, der forlader hinanden og går på jagt efter nye mager. Bedsteforældrene, der træder til og passer slægtens yngste. De ældre, der begynder at glemme i livets efterår. Og til sidst døden, som siden tidernes morgen har været kilde til frygt og filosofisk undren for mennesket.Som ekspert i dyr trækker Anders Koefoed gennem bogen en række oplysende og underholdende paralleller til stadierne i alle de andre levende væseners liv og forklarer, at vi mennesker ikke er alene med vores mærkværdigheder. Flagermus pludrer også kærligt til deres afkom. Hunde og køer bliver også umulige teenagere. Og de gamle løver tager sig også af de unge i flokken. Der er en mening med det meste, hvis vi kigger rundt i livets store træ. 

One of today's most accomplished biologists and gifted storytellers reveals the rules that regulate all lifeHow does life work? How does nature produce the right numbers of zebras and lions on the African savanna, or fish in the ocean? How do our bodies produce the right numbers of cells in our organs and bloodstream? In The Serengeti Rules, award-winning biologist and author Sean Carroll tells the stories of the pioneering scientists who sought the answers to such simple yet profoundly important questions, and shows how their discoveries matter for our health and the health of the planet we depend upon.One of the most important revelations about the natural world is that everything is regulated—there are rules that regulate the amount of every molecule in our bodies and rules that govern the numbers of every animal and plant in the wild. And the most surprising revelation about the rules that regulate life at such different scales is that they are remarkably similar—there is a common underlying logic of life. Carroll recounts how our deep knowledge of the rules and logic of the human body has spurred the advent of revolutionary life-saving medicines, and makes the compelling case that it is now time to use the Serengeti Rules to heal our ailing planet.Bold and inspiring, The Serengeti Rules illuminates how life works at vastly different scales. Read it and you will never look at the world the same way again.

Discussing the issue of male germline mutagenesis and the effects on developmental defects in the next generation, this book provides analysis of the fundamental mechanisms of mutations covering both clinical and experimental aspects.

This detailed volume compiles numerous methods to explore fly oogenesis. Beginning with updated protocols from isolating and staining the ovary to numerous imaging techniques and genetic protocols for cell-specific assessment and CRISPR-mediated mutagenesis, the volume continues by detailing techniques from assessing cytoskeletal structures to uncovering protein-protein interactions, with closing chapters exploring how Drosophila oogenesis can be used in the classroom and in outreach programs to increase interest in biomedical research, STEM education, and STEM careers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Drosophila Oogenesis: Methods and Protocols serves as an ideal guide for both new and expert researchers working with this robust and versatile model organism.

Insect Ecomorphology: Linking Functional Insect Morphology to Ecology and Evolution offers up-to-date knowledge and understanding of the morphology of insects and the functional basis of their diversity. This book covers the form and function of insect body structures in relation to their physiological performance capabilities, biological roles, and evolutionary histories. Written by international experts, the book explores the ecomorphology of functional systems such as insect feeding, locomotion, sensing, and egg laying. The combination of conceptual and review chapters, methodological approaches, and case studies enables readers to delve into active research fields and to gain an understanding of the form-function-performance paradigm. This book uncovers key structures of the various regions of the insect body, elucidates their function, and investigates their ecological and evolutionary implications. Insect Ecomorphology is thus a vital resource for entomologists, biologists, and zoologists, especially those seeking to understand more fully the morphology and physiological impacts of insects in correlation to their environments and to evolution.

Since the publication of the previous editions, there has been increased focus on the use of adipose-derived stromal/stem cells (ASC) and stromal vascular fraction (SVF) cells in three-dimensional hydrogel-based scaffolds for the development of microphysiological systems (MPS) serving as in vitro humanized assays and alternatives to in vivo pre-clinical animal models. This third edition volume discusses of the latest technology and advancements in the field of human-derived ASC and SVF. The chapters in this book are organized into four parts. Part One focuses on human ASC¿s isolation, characterization, and differentiation. Part Two describes the isolation and characterization of ASC and SVF from canine, feline, and murine tissues. Part Three looks at hydrogels, scaffolds, and microphysiological systems, and Part Four talks about the new assays and applications using ASC. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Adipose-Derived Stem Cells: Methods and Protocols, Third Edition is a valuable resource for both novice and experts researchers interested in learning more about this important and developing field.

This detailed volume explores techniques for the isolation, purification, and establishment of in vitro germ cell (GS) systems at different stages of development in a variety of organisms, including chickens, mice, rats, and humans. The book additionally describes cutting-edge analytic and informatic tools to study germ cell development at the single cell level and meiotic recombination. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Germ Cell Development: Methods and Protocols provides new insight into the understanding of basic biological aspects of germ cell biology, as well as the opportunity for in vitro manipulation of germ cells for toxicology studies and for genetic intervention.

This new volume of the book series Advances in Anatomy, Embryology and Cell Biology provides a complete and exhaustive overview of the morphofunctional organization of the mammalian carotid body, a polymodal chemosensory organ responsible for the maintenance of blood gas homeostasis. The authors review the state of the art of the neurochemical anatomy of carotid body¿s cell populations with a special reference to their structural and neurochemical plasticity. The essential role of this organ in the generation, progression and maintenance of cardiorespiratory and metabolic diseases in humans and other mammals is presented. Finally, the book summarizes current knowledge on the stem cell niche in the mammalian carotid body and discusses its contribution to replacement cell therapy and other potential applications in translational research. This book represents an essential reading for physiologists, anatomists, cell, and developmental biologists, as wellas physicians, veterinarians, and biomedical researchers.

This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells.Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.

Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.

This fully updated volume collects laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. Beginning with a section detailing basic principles of teratogenicity, the book continues with application of in vitro models for teratogenic screening to predict toxicity in embryonic animals and humans, as well as a variety of well-established in vivo animal model tests, which offer solutions for evaluating the efficacy and the teratogenicity of compounds in preclinical trials before human safety testing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Teratogenicity Testing: Methods and Protocols, Second Edition serves as an ideal guide to tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.

This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the molecular/genetic, cellular, and whole organism levels. Exploring methods that apply stress to hematopoiesis, the book also contains chapters focused on better understanding the role of hematopoietic niches and their cellular components, as well as in vivo models that test and quantitate stem cell function and are key to further development of therapeutic applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Hematopoietic Stem Cells: Methods and Protocols serves as a valued addition to laboratories focused on understanding hematopoietic stem cell biology and the therapeutic advances that can be derived from it.