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This book discusses computational methods related to biological models using mathematical tools and techniques. The book chapters concentrate on numerical and analytical techniques that provide a global solution for biological models while keeping long-term benefits in mind. The solutions are useful in closely understanding biological models, and the results will be very useful for mathematicians, engineers, doctors, scientists and researchers working on real-life biological models. This book provides significant and current knowledge of biological models related to real-life applications. The book covers both methods and applications.
This unique comprehensive compendium provides extensive studies on reversible cellular automata (RCAs), exhibiting a wide range of interesting phenomena similar to the Game-of-Life, a well-known irreversible CA.The useful reference text also introduces innovative approaches to constructing universal computers in a reversible cellular space. Numerous figures are included to illustrate the evolution of RCA configurations, and to elucidate theoretical results on RCAs. Additionally, readers can observe evolution processes of various RCAs on the free CA simulator Golly using supplementary files.
This proceedings of 15th CHAOS2022 International Conference highlights recent developments in nonlinear, dynamical, and complex systems. The conference was intended to provide an essential forum for Scientists and Engineers to exchange ideas, methods, and techniques in the field of Nonlinear Dynamics, Chaos, Fractals and their applications in General Science and Engineering Sciences.The principal aim of CHAOS2022 International Conference is to expand the development of the theories of the applied nonlinear field, the methods, empirical data and computer techniques as well as the best theoretical achievements of chaotic theory. CHAOS2022 Conference provides a forum for bringing together the various groups working in the area of Nonlinear and Dynamical Systems, Chaotic theory and Application to exchange views and report research findings.
Integrative Omics: Concept, Methodology and Application provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference provides systemic 'step-by-step' coverage that begins with basic concepts from Omic to Multi Integrative Omics approaches followed by applications and emerging and future trends. All areas of Omics are covered, including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics, technology policy, and society research. This book covers recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science.
The general format of this book is I'll start with each concept, explaining it in a bunch of sections and graphical examples. I will introduce you to some of the notations and fancy terminologies that data scientists like to use so you can talk the same language, but the concepts themselves are generally pretty simple. After that, I'll throw you into some actual Python code that actually works that we can run and mess around with, and that will show you how to actually apply these ideas to actual data.
Become a Unity Shaders Guru will help you understand Unity's latest shading tools and dive deep into its advanced features.
This Faraday Discussion volume brings together internationally leading experimental and theoretical scientists from across the fields of astronomy, chemistry, and physics to explore and exchange their ideas about our chemical understanding of the universe.
Although there is much literature on organisational learning, mathematical formalisation and computational simulation, there is no literature that uses mathematical modelling and simulation to represent and explore different facets of multilevel learning. This book provides an overview of recent work on mathematical formalisation and computational simulation of multilevel organisational learning by exploiting the possibilities of self-modeling network models to address it. This is the first book addressing mathematical formalisation and computational modeling of multilevel organisational learning in a systematic, principled manner. A self-modeling network modeling approach from AI and Network Science is used where in a reflective manner some of the network nodes (called self-model nodes) represent parts of the network¿s own network structure characteristics. This is supported by a dedicated software environment allowing to design and implement (higher-order) adaptive network models by specifying them in a conceptual manner at a high level of abstraction in a standard table format, without any need of algorithmic specification or programming. This modeling approach allows to model the development of knowledge in an organisational setting in a neatly structured manner at three different levels for the usage, adaptation and control, respectively, of the underlying mental models. Several examples of realistic cases of multilevel organisational learning are used to illustrate the approach. Crucial concepts such as the aggregation of mental models to form shared mental models out of individual mental models are addressed extensively. It is shown how to model context-sensitive control of organisational learning taking into account a wide variety of context factors, for example relating to levels of expertise of individuals or to leadership styles of managers involved. Mathematical equilibrium analysis of models of organisational learning is also addressed, among others allowing verification of correctness of the implemental models in comparison to their conceptual design. Chapters in this book also contribute to the Management and Business Sciences research by demonstrating how computational modeling can be used to capture complex management phenomena such as multilevel organizational learning. This book has a potential implication for practice by demonstrating how computational modeling can be used to capture learning scenarios, which then provide a basis for more informed managerial decisions.
Gathering the proceedings of the 14th CHAOS2021 International Conference, this book highlights recent developments in nonlinear, dynamical and complex systems. The conference was intended to provide an essential forum for Scientists and Engineers to exchange ideas, methods, and techniques in the field of Nonlinear Dynamics, Chaos, Fractals and their applications in General Science and the Engineering Sciences.The respective chapters address key methods, empirical data and computer techniques, as well as major theoretical advances in the applied nonlinear field. Beyond showcasing the state of the art, the book will help academic and industrial researchers alike apply chaotic theory in their studies.Chapter "e;On the Origin of the Universe: Chaos or Cosmos"e; is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com
This book constitutes the proceedings of the 15th International Symposium on NASA Formal Methods, NFM 2023, held in Houston, Texas, USA, during May 16-18, 2023. The 26 full and 3 short papers presented in this volume were carefully reviewed and selected from 75 submissions. The papers deal with advances in formal methods, formal methods techniques, and formal methods in practice.
This book describes a unique combination of quantum chemical methods for calculating the basic physical properties of luminescent materials, or phosphors. These solid inorganic materials containing an optically active dopant are key players in several major fields of societal interest, including energy-efficient lighting, solar cells, and medical imaging. The novel ab initio methods described in this book are especially designed to target the crowded and complex electronic excited states of lanthanide activators in inorganic solids. The book is well suited to both new and experienced researchers alike and appeals to a broad range of theoretical and experimental backgrounds. The material presented enables an adept understanding of elaborate calculations, which, in tandem with experiments, give essential insight into difficult luminescence problems and quandaries, thus fully preparing the reader for an educated search for new functional luminescent materials
What does platform thinking mean? It is the ability to put platform-based mechanisms at the core of digital business transformations in business.Digital platforms like Uber, Spotify, Airbnb, Booking.com, and many others completely re-shaped the daily life of millions of users. However, many innovation leaders struggle to conceive the significance of their impact. Platform-based business models are not just the real of geeks' startups, digital services, and Unicorns.This book shows there that their potential in creating value is higher than suspected.Even though platform ecosystems are complex, readers will take on a journey to become platform thinkers. Their eyes will be trained to look beyond what's visible and start reading the platform world around them. Then, they will be guided into a step-by-step process and learn how to write a new platform model from scratch.This book is the result of a decade of research. It offers both a framework and practical instruments to champion digital transformation in any organization. It is specially intended for those who are interested in the glittering platform world and are still trying to figure it out.
This book highlights the different aspects of the research project ¿E4C Horizon 2020 European Project¿ aimed at fighting the coronavirus by combining the best supercomputing resources and artificial intelligence with state-of-the-art experimental facilities up through clinical validation.Coronavirus disease has become an important public issue across the globe since December 2019. There is an urgent need to develop potent anti-COVID-19 agents for the prevention of the outbreak and stop viral infections.To this aim, a public¿private consortium composed by European and national infrastructures, center of excellence, universities, and a pharmaceutical company started the E4C Horizon 2020 EuropeanProject: Its core idea was to use the EXaSCale smArt pLatform Against paThogEns (EXSCALATE) supercomputing platform for a process known as ¿drug repurposing¿, namely to identify the most promising safe in man drugs for immediate treatment of the already infected population and then novel pan-coronavirus inhibitors to address future emergencies.This ambitious goal exploited a ¿chemical library¿ of 500 billion molecules, thanks to a processing capacity of more than 3 million molecules per second, made available by the computing power of the EXSCALATE platform.
This book constitutes the thoroughly refereed post-conference proceedings of the 8th International Conference on Modelling and Simulation for Autonomous Systems, MESAS 2021, held as a virtual event due COVID-19, in October 2021.The 30 full papers together with 2 short papers included in the volume were carefully reviewed and selected from 50 submissions. They are organized in the following topical sections: M&S of intelligent systems, R&D and application; and AxS/AI in context of future warfare and security environment and future challenges of Advance M&S Technology.
Time series data consist of a collection of observations obtained through repeated measurements over time. When the points are plotted on a graph, one of the axes is always time. Time series analysis is a specific way of analyzing a sequence of data points. Time series data are everywhere since time is a constituent of everything that is observable. As our world becomes increasingly digitized, sensors and systems are constantly emitting a relentless stream of time series data, which has numerous applications across various industries. The editors of this book are happy to provide the specialized reader community with this book as a modest contribution to this rapidly developing domain.
With growing interest in data mining and its merits, including the incorporation of historical or experiential information into statistical analysis, Bayesian inference has become an important tool for analyzing complicated data and solving inverse problems in various fields such as artificial intelligence. This book introduces recent developments in Bayesian inference, and covers a variety of topics including robust Bayesian estimation, solving inverse problems via Bayesian theories, hierarchical Bayesian inference, and its applications for scattering experiments. We hope that this book will stimulate more extensive research on Bayesian fronts to include theories, methods, computational algorithms and applications in various fields such as data science, AI, machine learning, and causality analysis.
This book explores the significance, challenges and benefits of digital twin technologies; it focuses in particular on various architectures, applications and challenges in the implementation of digital twins to Machine Learning and Internet of Things capabilities. Through the analysis of smart city and smart manufacturing case studies, the book explores the benefits of digital technologies in the Industry 4.0 Era.
"The Art of Randomness teaches readers to harness the power of randomness (and Python code) to solve real-world problems in programming, science, and art through hands-on experiments-from simulating evolution to encrypting messages to making machine-learning algorithms. Each chapter describes how randomness plays into the given topic area, then proceeds to demonstrate its problem-solving role with hands-on experiments to work through using Python code"--
This volume comprises papers from the 18th Conference on Systems Engineering Research (CSER). The theme of this volume, "e;Recent Trends and Advances in Model-Based Systems Engineering,"e; reflects the fact that systems engineering is undergoing a transformation motivated by mission and system complexity and enabled by technological advances such as model-based systems engineering, digital engineering, and the convergence of systems engineering with other disciplines. This conference is focused on exploring recent trends and advances in model-based systems engineering (MBSE) and the synergy of MBSE with simulation technology and digital engineering. Contributors have submitted papers on MBSE methods, modeling approaches, integration of digital engineering with MBSE, standards, modeling languages, ontologies and metamodels, and economics analysis of MBSE to respond to the challenges posed by 21st century systems. What distinguishes this volume are the latest advances in MBSE research, the convergence of MBSE with digital engineering, and recent advances in applied research in MBSE, including growing convergence with systems science and decision science. This volume is appropriate as a reference text in graduate engineering courses in Model-Based Systems Engineering.
Comprehensive, state-of-the-art coverage of every important simulation techniqueThis fully-revised book has the most comprehensive and up-to-date coverage of all aspects of a simulation study. Equally well suited for use in university courses, simulation practice, and self-study, the book offers clear and intuitive explanations as well as 300 figures, 218 examples, and 217 problems. You will get detailed discussions on modeling and simulation, simulation software, model verification and validation, input modeling, random-number and variate generation, statistical design and analysis of simulation experiments, experimental design, simulation optimization, agent-based simulation, machine learning, and much more.Authored by an operations research analyst and industrial engineer with more than 40 years of experience, Simulation Modeling and Analysis is widely regarded as the "bible" of simulation and now has more than 178,000 copies in print and 23,700 citations. This sixth edition has been streamlined, with several chapters downsized to eliminate outdated simulation programs or statistical techniques that are rarely used in practice and are unnecessarily complicated. Most analyses of simulation output data can now be done using three simple and familiar statistical formulas or expressions. A new chapter covers AI and machine learning and their application to simulation.Covers what are arguably the three most-innovative and popular simulation-software packages: AnyLogic, FlexSim, and SimioIncludes a set of instructor's resourcesHas been used at universities such as University of California-Berkeley, Stanford, Georgia Tech, Michigan, Cornell, Purdue, Virginia Tech, Penn State, Wisconsin, Columbia, Texas A&M, Washington, and Johns HopkinsWritten by a world-class expert in the field and an experienced educator who has presented more than 550 simulation and statistics short courses in 20 countries
This book presents a novel design framework for the development of Digital Twin (DT) models for process- and motion-control applications. It is based on system-data acquisition using cutting-edge computing technologies, modelling of physical-system behavior through detailed simultaneous simulation of different aspects of the system, and optimal dynamic behavior-matching of the process. The design framework is enhanced with real-time data analytics to improve the performance of the DT¿s behavior-matching with the real system or physical twin.The methods of creating a DT detailed in Digital-Twin-Enabled Smart Control Engineering make possible the study of a system for real-time controller tuning and fault detection. They also facilitate life-cycle analysis for multiple critical and dangerous conditions that cannot be explored in the corresponding real system or physical twin. The authors show how a DT can be exploited to enable self-optimizing capabilitiesin feedback control systems.The DT framework and the control-performance assessment, fault diagnosis and prognosis, remaining-useful-life analysis, and self-optimizing control abilities it allows are validated with both process- and motion-control systems and their DTs. Supporting MATLAB-based material for a case study and an expanded introduction to the basic elements of DTs can be accessed on an associated website. This book helps university researchers from many areas of engineering to develop new tools for control design and reliability and life-cycle assessment and helps practicing engineers working with robotic, manufacturing and processing, and mechatronic systems to maintain and develop the mechanical tools they use.
This book focuses on the problem of responsibility voids: these are cases where responsibility for a morally undesirable outcome cannot be attributed to any of the involved agents. Responsibility voids are thought to occur in collective decision-making and in the context of artificial intelligent systems. In these cases, philosophers worry that there is a shortfall of moral responsibility. In particular, such voids are often assumed to justify a notion of collective responsibility that cannot be reduced to individual responsibility. One of the aims of the book is to study how collective responsibility and joint action relate to individual responsibility and individual actions. The book offers a unifying framework for modelling moral responsibility by drawing from modal logic and game theory.The book investigates the possibility and scope of the problem of responsibility voids. One of its characteristics is its pluralistic perspective on moral responsibility: in contrast to giving a unique and all-encompassing definition of it, the book makes progress by spelling out and modelling several conceptions of moral responsibility. One of the appealing features of the book is that a relatively small range of models is used to investigate a variety of conceptions of moral responsibility. The unifying framework can thus be used to characterize the conditions under which responsibility voids are ruled out.
The book consists of a collection of papers from a corresponding conference regarding additive manufacturing. The yearly conference used to be held in German under the title "Konstruktion für die Additive Fertigung" and is held in English since last year. The topics are Specifications, potentials, and solutions Contributions to specifications on components and processes and methods for assessing the suitability of components and the application of additive manufacturing and finding solutions for concepts and design Design and optimization Contributions to the development and design of components, their design to ensure functional requirements and manufacturability, and methods and tools for optimization components Simulation, validation, and quality assurance Contributions to approaches for the computer-aided and physical validation of components, the testing of components and material, and measures to ensure quality aspects Process chain and business modelsContributions to their integration of additive manufacturing processes into existing processes and measures to increase value creation and the creation of new business models.
The textbook is intended for teaching MATLAB language and its applications. The book is composed of three parts: MATLAB programming, scientific computing with MATLAB, and system simulation with Simulink. Since MATLAB is widely used in all fields of science and engineering, a good introduction to the language can not only help students learn how to use it to solve practical problems, but also provide them with the skills to use MATLAB independently in their later courses and research. The three parts of the book are well-balanced and tailored to the needs of engineering students, and the mathematical problems commonly encountered in engineering can be easily solved using MATLAB. This textbook is suitable for undergraduate and graduate students majoring in science and engineering.The study guide of this textbook could be accessed via: http://sn.pub/thGR7v. This website provides links to recorded teaching videos, MATLAB toolbox for the book, interactive slide decks files in Powerpoint documents, and solution manuals by the authors.
The Bioethics of Space Exploration provides a comprehensive discussion of the possible bioethical issues and challenges that may arise when considering future long-term space missions. Because of numerous threats within the space environment, many consider the concept of radically modifying humans to be a serious and perhaps even necessary option. Konrad Szocik presents what types of ethical and bioethical challenges may await participants on commercial, scientific, and colonizing missions, and provides a new perspective into the potential for radical biomedical technologies.
This book helps readers easily learn basic model checking by presenting examples, exercises and case studies. The toolset mCRL2 provides a language to specify the behaviour of distributed systems, in particular where there is concurrency with inter-process communication. This language allows us to analyse a distributed system with respect to its functional requirements. For example, biological cells, supply chain management systems, patient support platforms, and communication protocols.The underlying technique is based on verifying requirements through model checking. The book explains the syntax of mCRL2 and offers modelling tips and tricks.
This book presents the state of the art in High-Performance Computing on modern supercomputer architectures. It addresses trends in hardware and software development in general. The contributions cover a broad range of topics, from performance evaluations in context with power efficiency to Computational Fluid Dynamics and High-Performance Data Analytics. In addition, they explore new topics like the use of High-Performance Computers in the field of Artificial Intelligence and Machine Learning. All contributions are based on selected papers presented in 2021 at the 31st Workshop on Sustained Simulation Performance, WSSP31, held at HLRS in Stuttgart, Germany, and WSSP32, held at Tohoku University in Sendai, Japan.
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