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KRAS Drug Discovery: Past, Present and Future is a comprehensive overview of the state-of-the-art medicinal chemistry approaches towards targeting the formerly undruggable oncogene, KRAS. It includes Seminal medicinal chemistry case histories of KRASG12C inhibitors such as Sotorosib, the first approved KRASG12C inhibitor for NSCLC, alongside the latest advances towards identification of in vivo tools and development candidates targeting KRAS G12D, KRAS G13C and other mutations. The book also provides the reader with a comprehensive overview of the in vitro assay systems, in vivo pharmacology xenograft models and chemical biology tools available to characterize small molecule inhibitors of KRAS.
"Unique in its approach and really helpful with its information - this book is a must have for any owner" Written for the admirers, fans and owners of this wonderful breed, we are confident that you will greatly benefit from the techniques and information in this book. A must have addition to your collection. Written for the admirers, fans and owners of this wonderful breed, we are confident that you will greatly benefit from the techniques and information in this book. A must have addition to your collection.
A selection of the next best writing by A. A. Gill, 'by miles the most brilliant journalist of our age' (Lynn Barber).
A selection of the very best writing by A. A. Gill, 'by miles the most brilliant journalist of our age' (Lynn Barber).
A collection of the very best recent journalism of A. A. Gill, 'by miles, the most brilliant journalist of our age' (Lynn Barber).
Pour Me, a gripping memoir by Adrian Gill, is a must-read for all book enthusiasts. Published in 2016 by Orion Publishing Co, this book has made a significant impact in the literary world. The book falls under the genre of autobiography, providing a candid and deeply moving account of Gill's life. As the title suggests, 'Pour Me' is a tale poured from the heart, filled with raw emotions and profound insights. This book is a testament to Gill's exceptional storytelling skills and his ability to captivate readers with his unique perspective. Published in English, 'Pour Me' is a compelling read that leaves a lasting impression. Orion Publishing Co has truly outdone itself by bringing this gem to the literary market.
Britain's most readable journalist takes on his biggest challenge - America.
A new collection of dazzling travel pieces from SUNDAY TIMES journalist and critic A.A. GILL.
The first collection of food writing by Britain's funniest and most feared critic
Foreigner Adrian Gill (a Scot) goes in search of the essence of England and the English
A collection of travel writing by Britain's funniest and most feared critic.
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