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Thirty-year-old John Balwin has just lost his beloved fiancée to cancer, and he decides it is time to leave New York City, the only home he has ever known. He will take a thirty-day trip across the United States to start a fresh new life in San Francisco, California, where a new job and, perhaps, a new love awaits him. The only thing left to do is to say good-bye to his beloved city, and he decides on a last visit to Central Park. There he meets a woman who will change his life forever-seventy-two-year-old Harriet Dinsmore. He agrees to bring her along on his cross-country trek, and their journey begins. Along the way, the pair pick up two more senior women, and together the four continue westward, transforming from a band of strangers into a family. But along the way, Harriet is plagued by visions of the dead-such as Civil War soldiers at Gettysburg. One apparition in particular begins to haunt Harriet over and over again. A woman is beckoning to her, calling for Harriet to join her in the spirit realm. Could the woman be an omen that Harriet is not long for this world?
The hypothalamus is a part of the brain, which is structurally small but functionally significant. The brainstem and its reticular formation are extremely interconnected with the hypothalamus. It is a part of the limbic system and it has connections to other limbic structures such as septum and amygdala. It is also well connected to the areas of the autonomous nervous system. The hypothalamus works as a control center for various endocrine functions. It regulates endocrine systems by secreting various hormones such as oxytocin, growth hormone-releasing hormone, gonadotropin-releasing hormone, corticotropin-releasing hormone and antidiuretic hormone. Hypothalamic disease is a type of disorder which can lead to disruptions in growth, weight, emotions, sleep cycles, etc. It can also result in hypopituitarism, neurogenic diabetes insipidus, tertiary hypothyroidism, and developmental disorders. There are several causes of hypothalamic disease such as head trauma, radiation, tumor, genetic disorders, lesion, surgery, and illness caused due to malnutrition. This book attempts to understand the anatomy and dysfunction of the hypothalamus along with disease management. It will serve as a valuable source of reference for graduate and post graduate students.
The hypothalamus is a functionally significant part of the brain. It works as a neural control center for entire endocrine systems, specifically in vertebrates. It maintains the internal balance of the body, which is referred to as homeostasis. Adrenal glands and thyroid gland are the primary endocrine glands in human beings. There are some glands that signal each other in sequence, commonly known as an axis, including hypothalamic-pituitary-adrenal axis. The anterior pituitary regulates several endocrine glands and organs, which is a part of the central neuroendocrine function in hypothalamus. Complex homeostatic mechanisms, several hormonal and behavioral circadian rhythms, crucial behaviors and complicated patterns of neuroendocrine outputs are coordinated through hypothalamus. The extreme lateral part of the ventromedial nucleus of the hypothalamus is liable for controlling food intake. This book contains some path-breaking studies on endocrine functions and hypothalamus. Those in search of information to further their knowledge will be greatly assisted by it.
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