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Alzheimer's disease is the most frequent cause of dementia that slowly and progressively causes cognitive impairment and profoundly alters the daily activities of the patients. Approximately, ten percent of all persons over the age of seventy experience significant memory loss, and in more than half of the cases, the cause is Alzheimer's disease.This reference book is an update on the most relevant pathological and clinical findings of this neurological disorder. Chapters cover the basic hypothesis of Alzheimer's disease, pathological features of the disease in the brain, Alzheimer's disease diagnosis and therapy. Information provided in the book is focused on research in developed countries.The book offers students of medicine and nursing as well as medical practitioners and specialists (internists, neurologists, gerontologists, and psychiatrists), the necessary information to understand the pathological and clinical aspects of the disease in depth, with the goal of improving medical outcomes in the care of their patients.
It is well known that arterial hypertension is the most important and frequent cardiovascular risk factor. The damage caused to the arterial walls accounts for the high prevalence of some disorders such as ischemic heart disease, peripheral artery disease, and stroke. When the histological lesion occurs in the Willis¿circle, patients can suffer from different types of stroke. Therefore, hypertension and stroke cannot be considered separately as individual entities, but as a pathogenic symbiosis between the two. Cerebrovascular disease is one of the most common and devastating disorders today; stroke can be ischemic or hemorrhagic. Stroke is the second leading cause of death worldwide, which caused 6.2 million deaths in 2011. It is well-established that the incidence of cerebrovascular diseases increases with age, and the number of strokes is set to increase as the elderly population grows. A stroke, or cerebrovascular accident, is defined as an abrupt onset of a neurologic deficit that is attributable to a focal vascular cause.
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