Bøger af Costas Demetzos

Comprehensive reference delivering a framework to develop and assess nanosystems that provide unique advantages in biomedical applications Nanotechnology in Therapeutics explores the idea that by studying in depth the behavior of living organisms, especially the functionality of their cell membranes, we can develop and evaluate innovative bio-inspired nanosystems that are able to deliver small molecules, biomolecules like proteins, peptides, and other genetic material in terms of the production of new therapies and vaccines. The main concept promoted in this book is an integrated approach for producing new medicines following the nanotoxicity, biotoxicity, regulatory, and ethical guidelines, which are also covered in the book. The book is divided into three parts. Part A provides an introduction and a historical overview of nanotechnology. Part B delves deeper into issues relating to lipid and polymeric nanostructures in medicine. Part C presents the regulatory landscape around nanotechnology and nanomedicine, while highlighting the need to keep an eye on emerging technologies such as Artificial Intelligence and Machine-Learning. Overall, this book opens up biomedical applications for previously challenging drugs and drug targets. Written by a highly qualified professor with significant pertinent research experience, Nanotechnology in Therapeutics includes discussion on: Eukaryotic cell membranes, their structural properties, and the thermodynamic payload of their lipid bilayersThe DLVO (Derjaguin, Landau, Verwey and Overbeek) theory as a scientific tool for studying the stability and the behavior of nanoparticlesLiposomes, lipid nanoparticles, and solid lipid nanoparticles, as well as polymeric nanoparticles, like micelles, polymersomes, and dendrimersIssues in the approval process of nanomedicines by the regulatory agencies, such as complexity, chaos, and nonlinear dynamics With comprehensive coverage of novel concepts that have the potential to transform how new medicines are designed and developed, Nanotechnology in Therapeutics is an essential resource on the subject for chemists in industry, as well as biomedical and pharmaceutical engineers.

This book presents modern trends that regard the utilization of advanced functional materials in the development of innovative pharmaceuticals. It will be useful for upper undergraduate and graduate students, young researchers, scientists who want to enrich their knowledge of advanced drug delivery nanocarriers and their applications.

Le livre "La voix de la science - Le silence de la nature" cherche à mettre en lumière les processus et phénomènes évolutifs silencieux et sans bruit qui se déroulent dynamiquement dans la nature sans que nous puissions les percevoir en raison de l'échelle à laquelle ils se produisent. En outre, il vise à présenter la recherche scientifique, les outils scientifiques intemporels et les tournants de la pensée humaine qui sont utilisés dans le macrocosme et constituent la voix de la communauté scientifique dans notre effort pour comprendre ces processus naturels silencieux et l'évolution. Ce dialogue entre le macrocosme et le microcosme comme moyen de comprendre la création et l'évolution de toutes les espèces constitue la sagesse sous-jacente de l'ordre naturel, son déterminisme pour ainsi dire. Le silence de la nature "porte" les créations que les êtres humains tentent d'examiner à travers la voix de la science. La philosophie constitue le moyen que les êtres humains utilisent pour construire une compréhension des processus de création et d'évolution, afin de ne pas se perdre dans le processus sans fin de "la fondation du cosmos" et de la création, et afin de dépasser leurs imperfections et faiblesses inhérentes.

O livro "A Voz da Ciência - O Silêncio da Natureza" procura realçar os processos e fenómenos evolutivos silenciosos e sem som que se desenrolam dinamicamente na natureza sem que os possamos perceber devido à escala em que ocorrem. Além disso, pretende mostrar a investigação científica e os instrumentos científicos intemporais e pontos de viragem no pensamento humano que são utilizados no macrocosmo e constituem a voz da comunidade científica no nosso esforço para compreender esses processos naturais silenciosos e a evolução. Este diálogo entre macrocosmo e microcosmo como meio de compreender a criação e a evolução de todas as espécies constitui a sabedoria subjacente à ordem natural, o seu determinismo, por assim dizer. O Silêncio da Natureza 'transporta' as criações que os seres humanos tentam examinar através de A Voz da Ciência. A filosofia constitui o meio que os seres humanos utilizam para construir uma compreensão dos processos de criação e evolução, a fim de não se perderem no processo interminável da "fundação do cosmos" e da criação, e a fim de ultrapassarem as suas imperfeições e fraquezas inerentes.

Il libro "La voce della scienza - Il silenzio della natura" vuole mettere in luce i processi e i fenomeni evolutivi silenziosi e insonorizzati che si svolgono dinamicamente in natura senza che noi possiamo percepirli a causa della scala in cui avvengono. Inoltre, intende presentare la ricerca scientifica e gli strumenti scientifici senza tempo e le svolte del pensiero umano che vengono utilizzati nel macrocosmo e che costituiscono la voce della comunità scientifica nel nostro sforzo di comprendere questi processi naturali silenziosi e l'evoluzione. Questo dialogo tra macrocosmo e microcosmo come mezzo per comprendere la creazione e l'evoluzione di tutte le specie costituisce la saggezza di fondo dell'ordine naturale, il suo determinismo per così dire. Il silenzio della natura "trasporta" le creazioni che gli esseri umani cercano di esaminare attraverso la voce della scienza. La filosofia costituisce il mezzo che gli esseri umani usano per costruire una comprensione dei processi di creazione ed evoluzione, per non perdersi nel processo senza fine della "fondazione del cosmo" e della creazione, e per superare le loro imperfezioni e debolezze intrinseche.

Das Buch "The Voice of Science - The Silence of Nature" will die stillen und geräuschlosen Evolutionsprozesse und -phänomene aufzeigen, die sich in der Natur dynamisch entfalten, ohne dass wir sie aufgrund des Ausmaßes, in dem sie sich abspielen, wahrnehmen können. Darüber hinaus sollen die wissenschaftliche Forschung und die zeitlosen wissenschaftlichen Werkzeuge und Wendepunkte des menschlichen Denkens vorgestellt werden, die im Makrokosmos eingesetzt werden und die Stimme der wissenschaftlichen Gemeinschaft in unserem Bemühen darstellen, diese stillen natürlichen Prozesse und die Evolution zu verstehen. Dieser Dialog zwischen Makrokosmos und Mikrokosmos als Mittel zum Verständnis der Schöpfung und der Evolution aller Arten stellt die zugrunde liegende Weisheit der natürlichen Ordnung dar, sozusagen ihren Determinismus. Die Stille der Natur "trägt" die Schöpfungen, die der Mensch durch die Stimme der Wissenschaft zu untersuchen versucht. Die Philosophie ist das Mittel, das der Mensch einsetzt, um ein Verständnis für die Prozesse der Schöpfung und der Evolution zu entwickeln, um sich nicht in dem endlosen Prozess der "Gründung des Kosmos" und der Schöpfung zu verlieren und um seine eigenen Unvollkommenheiten und Schwächen zu überwinden.

From Current to Future Trends in Pharmaceutical Technology explores the current trends of this field and creates a multi-aspect framework for the reader. The book covers topics on pharmaceutics, pharmaceutical engineering, pre-formulation protocols, techniques, innovative excipients, bio-printing techniques, scale-up based on formulas on-a-chip, and regulatory aspects based on new scientific achievements. Modified dosage forms, new aspects on the compatibility of drug excipients interactions, and drug release by various dosage forms are included. Physical pharmacy (physical and biological stability of dosage forms), innovative excipients, patents on innovative formulations and regulatory issues related to the approval process of medicines are also discussed. The book is a valuable resource for a wide audience of academics, industrial researchers and professionals working in this field as the development of efficient and safe medicines is critical to future needs.