Bøger af Daniel Fletcher

MicroRNAs (miRNAs) are a category of non-coding RNAs which play a crucial role in the regulation of gene expression. A vast range of miRNAs are transcribed from DNA sequences in primary miRNAs, which are then processed into precursor miRNAs and then into mature miRNAs. The interaction of miRNAs with their target genes is dynamic and depends on a variety of factors including the abundance of miRNAs and target mRNAs, the affinity of miRNA-mRNA interactions, and miRNA subcellular location. They can be secreted into extracellular fluids and transferred to target cells by vesicles like exosomes or through a bind to proteins such as argonautes. Furthermore, miRNAs regulate the activities of host cell and also secrete and transport those host cells to recipient cells. This book provides significant information to help develop a good understanding of microRNAs. The readers would gain knowledge that would broaden their perspective in this area of study.

MicroRNA (miRNA) refers to a small single-stranded non-coding RNA molecule. It can be found in animals, plants and some viruses. miRNAs function in post-transcriptional regulation of gene expression and RNA silencing. They work through base-pairing along with complementary sequences in mRNA molecules. Several mammalian cell types contain a high concentration of miRNAs as circulating in extracellular fluid, which are released into body fluids such as blood and cerebrospinal fluid, and could be used as biomarkers in a variety of disorders. MiRNAs play a role in gene regulation and can also produce histone modifications and DNA methylation at promoter sites, which can affect the target gene expression. MiRNAs are important in modulating complex enzymatic cascades, such as the hemostatic blood coagulation system. The topics included in this book on microRNAs are of utmost significance and bound to provide incredible insights to the readers. Researchers and students engaged in the study of this molecule will be assisted by it.

This masterfully crafted guide to ninjitsu or budo explores in depth the history, culture and philosophy of this fascinating and enduring Japanese martial art. Budo is one of the least understood forms of art in the world. Even more than skills or techniques, the teachings of budo require faith to learn and courage to understand. One of the fundamental teachings of budo is ninjutsu, the art of perseverance that forms the basis of the Japanese martial arts.The lessons in this book come directly from experiencing the living vitality of the world's foremost master of the ninja arts, Masaaki Hatsumi. Through the use of stories, poetry, art, and earned wisdom, the authors move beyond the common image of the martial arts and reveal the nature of the unexpected changes in themselves as they struggled to come to terms with what being a martial artist in the ninja tradition meant.The Art of Life and Death is a reflection of the discipline, the aesthetics, and the philosophy that lies hidden within the martial way. It is a glimpse at the hidden potential of the martial arts, one where the practitioner can embrace transcendence and transformation in order to face all the fears that litter life and also life's most fearsome opponent: Death.

This masterfully crafted guide to ninjitsu or budo explores in depth the history, culture and philosophy of this fascinating and enduring Japanese martial art. Budo is one of the least understood forms of art in the world. Even more than skills or techniques, the teachings of budo require faith to learn and courage to understand. One of the fundamental teachings of budo is ninjutstu, the art of perseverance that forms the basis of the Japanese martial arts.The lessons in this book come directly from experiencing the living vitality of the world's foremost master of the ninja arts, Masaaki Hatsumi. Through the use of stories, poetry, art, and earned wisdom, the authors move beyond the common image of the martial arts and reveal the nature of the unexpected changes in themselves as they struggled to come to terms with what being a martial artist in the ninja tradition meant.The Art of Life and Death is a reflection of the discipline, the aesthetics, and the philosophy that lies hidden within the martial way. It is a glimpse at the hidden potential of the martial arts, one where the practitioner can embrace transcendence and transformation in order to face all the fears that litter life and also life's most fearsome opponent: Death.

"Japanese Throwing Weapons" is a detailed instruction manual for learning authentic shuriken throwing techniques as practiced in Japan. Daniel Fletcher studied under Japan's most notable shuriken sensei, Yasuyuki Otsuka, of the Meifu Shinkage Ryu and in this book he reveals the secrets learned in his years of study and training. Fletcher explains the origins and purpose of the shuriken as a weapon and provides information on the various types of shuriken used by the historic samurai and ninjas. Fletcher's expert instructions and the enclosed DVD can help anyone become proficient in throwing these weapons.