Bøger af Dhananjay Mane

L'applicazione versatile dei composti eterociclici azotati e/o ossigenati ha reso quest'area di ricerca estesa dei chimici sintetici. I composti eterociclici azotati come le triazine, i benzimidazoli, i pirazoli, gli isossazoli e le piridine hanno ricevuto una notevole attenzione negli ultimi anni grazie alle loro ampie attività fisiologiche. Questi derivati sono molto utili in vari campi, ad esempio nei farmaci, nei coloranti, nei polimeri, nei tessuti, nell'agricoltura, ecc. I derivati triazinici sono stati utilizzati come erbicidi antimicrobici, antisettici urinari e agenti antinfiammatori. I derivati benzimidazolici possiedono un'ampia gamma di attività biologiche, come quelle antibatteriche, antimicotiche, antivirali e antielmintiche. Alla luce dell'indagine, si osserva che non c'è stato un solo tentativo di sintetizzare derivati s-triazinici incorporati con diidrofridina e cumarinile. Anche i benzimidazoli sono stati oggetto di minore attenzione, incorporati con società diidropiridiniche, pirazoliniche e isossazoliniche sostituite con N, per cui si è cercato di sintetizzare questi composti, la cui relazione struttura-attività è stata discussa in questo libro.

Les applications polyvalentes des composés hétérocycliques azotés et/ou oxygénés ont fait de ce domaine l'objet de recherches approfondies de la part des chimistes de synthèse. Les composés hétérocycliques azotés tels que les triazines, les benzimidazoles, les pyrazoles, les isoxazoles et les pyridines ont fait l'objet d'une attention considérable ces dernières années en raison de leurs nombreuses activités physiologiques. Ces dérivés sont très utiles dans divers domaines tels que les médicaments, les colorants, les polymères, les textiles, l'agriculture, etc. Les dérivés de la triazine ont été utilisés comme herbicides antimicrobiens, antiseptiques urinaires et agents anti-inflammatoires. Les dérivés du benzimidazole possèdent un large éventail d'activités biologiques telles que les activités antibactériennes, antifongiques, antivirales et antihelminthiques. À la lumière de l'enquête, on observe qu'il n'y a pas eu une seule tentative de synthèse de dérivés de la s-triazine incorporant des motifs de dihydrophyridine et de coumarinyle. Les benzimidazoles ont également fait l'objet de moins d'attention en incorporant des motifs de dihydropyridine, de pyrazoline et d'isoxazoline substitués en N, c'est pourquoi on a essayé de synthétiser ces composés.

Die vielseitige Anwendung von stickstoff- und/oder sauerstoffhaltigen heterozyklischen Verbindungen hat dazu geführt, dass dieser Bereich von synthetischen Chemikern intensiv erforscht wird. Stickstoffheterozyklische Verbindungen wie Triazine, Benzimidazole, Pyrazole, Isoxazole und Pyridine haben in den letzten Jahren aufgrund ihrer vielfältigen physiologischen Aktivitäten große Aufmerksamkeit erregt. Diese Derivate sind in verschiedenen Bereichen sehr nützlich, z. B. bei der Herstellung von Arzneimitteln, Farbstoffen, Polymeren, Textilien, landwirtschaftlichen Erzeugnissen usw. Triazin-Derivate wurden als antimikrobielle Herbizide, Antiseptika für den Urin und entzündungshemmende Mittel eingesetzt. Benzimidazol-Derivaten wird ein breites Spektrum an biologischen Aktivitäten zugeschrieben, wie z. B. antibakterielle, antimykotische, antivirale und antihelminthische Wirkungen. Aus der Übersicht geht hervor, dass kein einziger Versuch unternommen wurde, s-Triazin-Derivate mit Dihydrophyridin- und Cumarinyl-Anteilen zu synthetisieren. Benzimidazole, die mit N-substituierten Dihydropyridin-, Pyrazolin- und Isoxazolin-Resten verbunden sind, wurden ebenfalls weniger beachtet, weshalb der Versuch unternommen wurde, diese Verbindungen zu synthetisieren.

A aplicação versátil de compostos heterocíclicos de azoto e/ou oxigénio tornou esta área de investigação extensiva dos químicos sintéticos. Os compostos heterocíclicos azotados, como as triazinas, os benzimidazóis, os pirazóis, os isoxazóis e as piridinas, têm recebido uma atenção considerável nos últimos anos devido às suas vastas actividades fisiológicas. Estes derivados são muito úteis em vários domínios, por exemplo, fármacos, corantes, polímeros, têxteis, agricultura, etc. Os derivados de triazina têm sido utilizados como herbicidas antimicrobianos, anti-sépticos urinários e agentes anti-inflamatórios. Os derivados do benzimidazol possuem uma vasta gama de actividades biológicas, tais como antibacteriana, antifúngica, antiviral e anti-helmíntica. À luz do inquérito, observa-se que não há uma única tentativa de sintetizar derivados de s-triazina incorporando com dihidrofiridina e cumarinilo. Os benzimidazóis também receberam menos atenção ao serem incorporados com dihidropiridina, pirazolina e isoxazolina substituídas por N, pelo que se tentou sintetizar estes compostos, cuja relação estrutura-atividade foi discutida neste livro.

Antibiotics are one of our most important weapons to cover bacterial infections and improve human life . Infectious diseases are the leaders among the challenging drug targets because of the multi-drug resist antimicrobial pathogens and continuous rise in the emerging infections from known and unknown sources. Tyrosine kinases are orally active, small molecules that have a favorable safety profile and can be easily combined with other forms of chemotherapy or radiation therapy. The combination of two pharmacophores into a single molecule is an effective and commonly used direction in modern medicinal chemistry for the exploration of novel and highly active compounds. A variety of safe and effective antiinflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. The pharmacophoric structural features of the selective COX-2 inhibitors possess a central heterocyclic five member ring system bearing two vicinal aryl moieties, such as pyrazole (celecoxib), 2(5H) furanone (rofecoxib), and isoxazole (valdecoxib).

The versatile application of nitrogen and / or oxygen heterocyclic compounds have made this area of extensive research of synthetic chemists. Nitrogen heterocyclic compounds like triazines, Benzimidazoles, pyrazoles, isoxazoles and pyridines have received considerable attention in recent years due to their wide physiological activities. These derivatives are very useful in various fields e.g. drugs dyes, polymers, textiles, agricultures etc. Triazine derivatives have been used as antimicrobial herbicides, urinary antiseptics and anti-inflammatory agents. Benzimidazole derivatives have been reported to posses wide range of biological activities such as antibacterial, antifungal, antiviral and antihelmintic. In the light of the survey it is observed that there is not a single attempt to synthesize s-triazine derivatives incorporating with dihydrophyridine and coumarinyl moieties. Benzimidazoles also received less attention incorporating with ¿ N- substituted dihydropyridine, pyrazoline and Isoxazoline moieties, therefore the attempt was made to synthesize these compounds.The structure activity relationship were discussed in this book.

Determination of exact quantity of drug in the drug formulation requires accurate and robust analytical method. Analytical method development and validation plays an important role in the drug discovery, development, and quality control of pharmaceutical products. The method should be simple and fast so that it can be adopted by any laboratory easily. The methods which are used in analysis of stability studies for assay and related substances should be stability indicating analytical methods. The peaks of solutes and impurities under determination should be pure and hence peak purity in the methods for determination of assay and related impurities should be passed. The developed methods need to be validated as per current regulatory guidelines. All the validated methods should pass the acceptance criteria as per industrial and regulatory norms.Due to these high expectations, pharma industry is suffering, since many of the firms are using regular conventional techniques to determine the drug quantities and their impurities. To keep the pace with rapid improvement in quality standards of drugs all over the world and keeping in view the essential requirements.