Bøger af Farnaz-Sadat Fattahi

Nano-fibers have attained great research attention owing to their unique physico-chemical characteristics and broad implementation potential. These one-dimensional (1-D) nano-structures are being increasingly applied in bio-medical fields such as manufacturing the scaffolding materials for regenerate new tissues owing to their great surface area-to-volume ratio, high porosity by interrelated pore-configuration, and the suitable surface structure for cell attachment, proliferation, growth, adhesion, viability and differentiation. Nano-fibrous scaffolds with porous construction can mimic the Extra Cellular Matrix structure in providing the suitable area for cells in their micro-environment. Detailed analyses of nano-fibers effects on cellular functions have been carried out to choose the most appropriate candidates for promoting new tissue-regeneration in human body. Constructing nano-fibrous scaffolds for cell cultivating and implanting the scaffold-cell matrix in human body for tissue- regeneration is the most necessary requirement for bio-scientists nowadays. This book will consider important notes about this process briefly form novel explorations in tissue-engineering field.

Les maillages nanofibreux font référence aux structures constituées de fibres polymères ultrafines. En raison de leur taille nanométrique avec un rapport résistance/poids excessif, ils conviennent très bien comme nanosystème pour administrer des molécules médicamenteuses. Les molécules médicamenteuses mélangées aux nanofibres peuvent être libérées du milieu environnant au moyen de divers mécanismes et de différentes manières (libération en rafale, libération durable et libération réglable). Les nanofibres peuvent être utilisées dans le cadre de stratégies de contrôle du taux de libération en tant que structures d'administration appropriées pour les molécules médicamenteuses. L'objectif de cette revue est de mettre en évidence la capacité des nanofibres en tant que nouvelles substances libératrices de profènes (médicaments dérivés de l'acide propionique, notamment le carprofène, le naproxène, le fénoprofène, le flurbiprofène, l'ibuprofène, le kétoprofène et l'acide tiaprofénique). Les profènes sont une classe d'anti-inflammatoires non stéroïdiens (AINS) non sélectifs. Ces molécules médicamenteuses sont des dérivés de l¿acide 2-phénylpropanoïque. Tous contiennent un centre chiral entraînant la formation de deux énantiomères (R et S) de chaque profène. Dans cette revue, des informations complètes seront rapportées sur les nouveaux progrès concernant les comportements de libération des molécules de profène à partir de la nouvelle délivrance nanofibreuse.

Nanofibrous meshes refer to the structures made of ultrafine polymeric fibers. Because of nanometer measure size with an excessive strength/weight ratio, they are actual suitable as a nanosystem for delivering drug molecules. Drug molecules which mixed in nanofibers, can be released from the surrounding environment by means of various mechanisms in different manners (burst release, sustainable release and tunable release). Nanofibers can be used by way of release rate controlling strategies as proper delivery structures for drug molecules. The objective of this review is to highpoint the capacity of nanofibers as novel releasing substances for profens (Propionic acid derivative drugs including Carprofen; Naproxen; Fenoprofen; Flurbiprofen; Ibuprofen; Ketoprofen and Tiaprofenic acid). The profens are a class of nonselective, nonsteroidal anti-inflammatory drugs (NSAIDs). These drug molecules are derivatives of 2-phenylpropanoic acid. All contain a chiral center resulting in the formation of two enantiomers (R and S) of each profen. In this review, full information will be reported about the new progresses for release behaviors of profen molecules form the novel nanofibrous delivery.

Environmental concerns are pushing industries for the use of renewable and bio-based materials. Considerable interest has been devoted to poly(lactic acid) (PLA) since this polymer has shown promising and excellent results in mechanical and environmental properties. Poly(lactic acid) properties can be improved by incorporation of nanoplatelets , nanofibers, nanocrystals and nanoparticles into polymer matrix. The reinforcement of poly(lactic acid) using these methods has attracted more researchers with the goal of making ¿green-nanocomposites¿ due to their extensive and potential applications. This BOOK reviewed the recent advances in the preparations , modification, fabrication and properties of poly(lactic acid) nanocomposites.

In recent years, the adaptation of tissue engineering techniques is necessary to progress the field of cardio-vascular bio-logy and advancing patient care. Through the high event of cardio-vascular disease and increasing amount of patients needing vascular admission, there is a considerable require for small-diameter (