Bøger af Finn McFarland

The JAK-STAT signal pathway refers to a cytokine-stimulated signal transduction pathway which plays an important role in numerous biological processes which include cell proliferation, differentiation, apoptosis and immune regulation. The signal transducer and activator of transcription (STAT) pathway is linked upstream with the Janus kinase (JAK) family of proteins. It is also capable of integrating inputs from several signaling pathways. Each member of the family performs a distinct role in signal transduction and is critical in mediating cellular responses to various types of cytokines. STAT family members particularly STAT3 and STAT5 have been associated with the progression of cancer. Persistent STAT3 and STAT5 activation is known to stimulate chronic inflammation, which makes healthy cells more susceptible to carcinogenesis. STAT3 is significantly linked to immune evasion and tumor growth. Several mechanisms appear to play a role in the activation of STAT5 proteins in human cancer, comprising miRNA- and hormone-regulated TFs, gene amplification, epigenetic alterations, aberrant growth factor signaling and altered proteolytic pathways. This book contains some path-breaking studies on the STAT pathway. It will serve as a valuable source of reference for graduate and postgraduate students.

Signal processing is a subfield of electrical engineering involved in analyzing, modifying and synthesizing signals such as sound, images and scientific measurements. The techniques of signal processing are used to improve transmission, storage efficiency, and subjective quality. They can also emphasize or detect components of interest in a measured signal. There are various categories of signal processing such as analog, continuous time, digital, discrete time, non-linear and statistical signal processing. Analog signal processing refers to the signal processing which is conducted on continuous analog signals through analog means. The techniques which are used to improve the accuracy and quality of digital communication is known as digital signal processing. Some of the prominent applications of signal processing are economic modeling and analysis, weather forecasting, oceanography, medical imagery (such as CAT and MRI), oil explorations, seismic studies, and data analysis. The objective of this book is to give a general view of signal processing with an emphasis on advanced techniques. It is an essential guide for both students and professionals.