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As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase.
The synucleinopathy sporadic Parkinson's disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer's disease.
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