Bøger af Himanshu Gupta

Nanotechnology is a relatively new science. Application of nanotechnology in medicine currently being developed involves employing nanoparticles to deliver drugs, or other substances to specific types of cells. Most toxicology data for nano particles usage are derived from in vitro studies and may not reflect in in vivo responses. Knowledge about their potential toxicity and health impact is essential before these nanomaterials can be used in real clinical settings.There are a few studies documenting the toxicity of Silver Nano Particles (SNP) & Gold Nano Particles (GNP) in vivo, for chronic based (90 days). Till date, there are very few reproductive nano toxicity studies for assessing the impact of SNP/GNP on testicular germ cells. In particular, their possible ability to penetrate inside the cells and in defining their localization. Efforts were directed to investigate the histopathological & ultrastructure analysis of NP¿s on the male germ. These studies cannot be overlooked, while using such NP¿s in various industries. Our findings could be applied in the reproductive biology related research, they are likely to be of great interest to the vision scientists, researchers, etc.

In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99mTc by direct labeling method. The labeling procedure was optimized to get maximum labeling efficiency(