Bøger af Jonah Randall

A circulating tumor cell (CTC) refers to a type of a cell that has been shed from a primary tumor into the lymphatic system or the vascular system, and is carried all over the body through blood circulation. CTCs have the ability to extravasate and become a source for the creation of new tumors in distant organs. The identification and analysis of CTC can aid in early patient prognoses and deciding suitable personalized therapy. The detection of CTCs using liquid biopsy has a number of advantages over conventional tissue biopsies. Liquid biopsies are non-invasive and can be used multiple times. They also provide valuable information about metastatic risk, disease progression and treatment success. Analysis of blood samples from cancer patients has an increased possibility of CTC detection as the disease progresses. This book unravels the recent studies on circulating tumor cells in cancer. It presents researches and studies performed by experts across the globe. This book is a vital tool for all researching and studying circulating tumor cells.

Circulating tumor cells (CTCs) are a rare subset of cells identified in the blood of patients having solid tumor. It serves as a seed for metastases. Cancer cells generally metastasize in two ways in the bloodstream, through single migratory CTCs or multicellular groupings. They imitate tumor properties and sustain tumor heterogeneity. They are also potentially useful as preclinical models, clinical biomarkers, and therapeutic targets. Furthermore, they have a potential clinical use as a component of liquid biopsy, where they can be used for early diagnosis, prognosis prediction, disease monitoring, molecular phenotyping and assessing therapy response. CTCs are also suitable for developing preclinical models, particularly 3D organoid cultures that might be used in tumor immunity, disease modelling, organoid biobanks, drug screening and genome editing. This book explores the status of current research on circulating tumor cells. Those in search of information to further their knowledge will be greatly assisted by it.