Bøger af Keith Seibert

Homeostasis refers to the ability of an organism to keep the body's internal environment within bounds that enable the organism to survive. Chemical regulation, thermoregulation and osmoregulation are the primary types of homeostatic regulations that occur in the body. Muscle regeneration is the ability of an adult muscle to regenerate damaged fibers and it represents an essential homeostatic function. It is an extremely coordinated program, which partly mimics the embryonic developmental program. It also includes the activation of the muscle compartment of stem cells, specifically satellite cells as well as other precursor cells. The activities of these cells are dependent on environmental signals. Muscle regeneration can be hampered by a number of pathological conditions either because of the increasing loss of stem cell populations or due to the absence of signals that prevent damaged tissues from effectively activating a regenerative program. Thus, it is possible that losing control over these cells will result in pathological cell differentiation. The topics included herein on muscle regeneration and homeostasis is of utmost significance and bound to provide incredible insights to readers. Those in search of information to further their knowledge will be greatly assisted by this book.

Skeletal muscles are organs found in the vertebrate muscular system that are usually connected to skeleton bones through tendons. It is the most abundant tissue in the human body and it is longer than other muscle tissues. It also has a strong innate ability to repair tissue damage occurred through an accident or degenerative illnesses, like muscular dystrophy, and regenerate new muscle fibers. Satellite cells and myogenic progenitors located between the muscle fiber membrane and the basal lamina are primarily responsible for regeneration. Skeletal muscles have the ability to regenerate and repair themselves following a trauma in a sophisticated and well-organized manner. This process requires the existence of varied cell populations, the up and down regulation of different gene expressions, along with the involvement of numerous growth agents. The topics in this book on the regeneration of skeletal muscles are of utmost significance and bound to provide incredible insights to readers. The readers would gain knowledge that would broaden their perspective in this area of orthopedics.