Bøger af Madhumita Roy

This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.¿

Cancer is uncontrolled proliferation of cells where environmental factors also play a role. Ground water contamination by inorganic arsenic poses several health problems including cancer. Chronic arsenic(As) exposure leads to development of skin carcinogenesis, both basal and squamous cell carcinoma. Chronic As intake leads to excess generation of ROS, which in turn causes DNA, protein and lipid damage. Epigenetics and EMT play crucial role in skin carcinogenesis. Several remedial measures have been adopted. Patients having skin cancer undergo surgery, radiation and chemotherapy, which are expensive and have side effects. Therefore, prevention of cancer is a better choice. Chemoprevention by the use of nontoxic agents which inhibit specific molecular steps in the carcinogenic pathway is the need of the hour. Use of phytochemicals for chemoprevention has been globally approved. Phytochemicals can work on all stages of carcinogenesis. Tea, the popular beverage has enormous anticancer potential. Black tea has the ability to modulate several genes, proteins implicated in skin carcinogenesis. Thus, black tea can be a potential phytochemical to counter skin carcinogenesis by As.

The book discusses cancer and the potential use of phytochemicals as cancer therapeutics.