Bøger af Michael R. Rose

Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population- genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host- pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. (c) 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.

Extending the human life-span past 120 years. The "e;green"e; revolution. Evolution and human psychology. These subjects make today's newspaper headlines. Yet much of the science underlying these topics stems from a book published nearly 140 years ago--Charles Darwin's On the Origin of Species. Far from an antique idea restricted to the nineteenth century, the theory of evolution is one of the most potent concepts in all of modern science. In Darwin's Spectre, Michael Rose provides the general reader with an introduction to the theory of evolution: its beginning with Darwin, its key concepts, and how it may affect us in the future. First comes a brief biographical sketch of Darwin. Next, Rose gives a primer on the three most important concepts in evolutionary theory--variation, selection, and adaptation. With a firm grasp of these concepts, the reader is ready to look at modern applications of evolutionary theory. Discussing agriculture, Rose shows how even before Darwin farmers and ranchers unknowingly experimented with evolution. Medical research, however, has ignored Darwin's lessons until recently, with potentially grave consequences. Finally, evolution supplies important new vantage points on human nature. If humans weren't created by deities, then our nature may be determined more by evolution than we have understood. Or it may not be. In this question, as in many others, the Darwinian perspective is one of the most important for understanding human affairs in the modern world. Darwin's Spectre explains how evolutionary biology has been used to support both valuable applied research, particularly in agriculture, and truly frightening objectives, such as Nazi eugenics. Darwin's legacy has been a comfort and a scourge. But it has never been irrelevant.

The author of this monograph proposes an evolutionary theory of senescence - that the force of natural selection declines proportionally with age after the onset of reproduction. He elaborates with evidence from cell biology, physiology and gerontology.