Bøger af Novartis Foundation

Transient Receptor Potential (TRP) genes were originally identified as encoding critical components of phototransduction in Drosophila. Since the discovery of the first mammalian transient receptor potential channel (TRPC) some eight years ago, more than 20 mammalian homologues have been reported.

In keeping with the Novartis series this book draws together contributions from an international and interdisciplinary group of experts. Involved here are those studying the mechanisms of light signalling to the vertebrate clock, the connections between central and peripheral clocks and the genetics of the vertebrate clock and clock proteins.

The object of this book is to gather together workers in the fields of epilepsy, those concerned with the basic science of resistance and the blood-brain barrier, and those with clinical experience of drug resistance in cancer, with a view to stimulating further work on drug resistance in epilepsy.

Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung.

Addresses the research on mast cells and basophils and its significance in relation to allergic and autoimmune diseases. This is an area of burgeoning interest, driven by increasing recognition of the fundamental importance of these cell types in several disease processes.

The cerebral cortex is the crowning achievement of evolution and the biological substrate of human mental capacities. Using a comparative evolutionary developmental approach to the study of its origin helps to offer new insights into this complex and important problem.

Many human diseases such as cancer, diabetes and neural disorders arise from the malfunction of signaling components. This is frequently due to alterations of multiple components of an integrated signaling network.

Rice is the most important food crop for over half the world's population. The challenge to produce enough rice for the future is a daunting one as the current rate of population growth outpaces increases in rice production. Science has a central role to play in raising rice productivity.

Over the past five years, there has been dramatic progress in unravelling the cellular circuitry involved in cardiac failure, as well as in normal cardiac growth, development and apoptosis. These studies have revealed new and unanticipated therapeutic targets in the heart.