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The idea of bringing out of this book started from a small publication on mitigating the amplicon contamination of a molecular biology laboratory in the resource limited settings. The work was published in the international Journal of Mycobacteriology. An initiative in eliciting the roll and importance of Molecular biology TB labs in the resource limited settings was strongly felt. While establishing the Molecular Biology laboratory at IRL Kolkata the constraints in overcoming the amplicon contamination during the proficiency testing of the samples was documented through rigorous onsite evaluation , monitoring and hand holding. The observations were meticulously analyzed and statistically evaluated for upliftment of the laboratory procedures . Adherence of Good Lab practice was ensured and repeated sentinel testing was done till the contamination overcome. The practice prompted us to publish our systematic observations in an international journal probing into most effective intervention for combating Amplicon Contamination. The Published work was reviewed and peer reviewed so many times to bring out the pit falls in establishing a Molecular biology Laboratory.
As a resolution of the well-known hierarchy problem,like supersymmetry the model of extra spatialdimension(s) proposed by N.~Arkani-Hamed,S.~Dimopoulos and G.~Dvali(ADD) in 1998, and byL.~Randall and R.~Sundrum(RS) in 1999, have generatedconsiderable enthusiasm among the physics community. In this thesis, we have made a phenomenologicalstudy of both of these models. After a briefintroduction of the ADD model and the RS modelin chapter 1 and chapter 2 and a brief review of theexisting phenomenlogical studies in chapter 3, wehave derived the order $kappa^2$ Feynman rules inthe context of ADD model. In chapter 5, we haveinvestigated theeffect of gravity in the DIS (i.e. the process $e^+ +p rightarrow e^+ X$) and compare our result withthat at HERA to constrain the parameters of the RSmodel. In chapter 6 and chapter 7, we haveinvestigated several phenomenologicalconsequences of the radion (which appears naturallyin the RS model in order to stabilize thesize of the fifth spatial dimension). Chapter 8contains the summary and the conclusion of the thesis.
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