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Sirtuins refer to a class of signaling proteins involved in metabolic regulation. They are members of the class III family of NAD-dependent histone deacetylases (HDAC). They are involved in a variety of physiological processes ranging from metabolism and endocrine function control to immune coordination and cellular responses to stress. Sirtuin-1 (SIRT1) plays an important role in epigenetics, immunology, and endocrinology. SIRT1's diverse roles include energy sensing metabolic homeostasis regulation, and deacetylation of histone and non-histone proteins in numerous tissues. It also facilitates neuro-endocrine regulation through hypothalamus-pituitary axis stimulation, and synthesis and maintenance of reproductive hormones via steroidogenesis. Some of the other functions involve maintenance of innate and adaptive immune systems via T and B cell maturation regulation, chronic inflammation, and autoimmune diseases. This book provides significant information of sirtuin biology as well as its importance in endocrinology and metabolic disease. It will provide comprehensive knowledge to the readers.
In this book, Shay Welch expands on the contemporary cognitive thinking-in-movement framework, which has its roots in the work of Maxine Sheets-Johnstone but extends and develops within contemporary embodied cognition theory.
This book investigates the phenomenological ways that dance choreographing and dance performance exemplify both Truth and meaning-making within Native American epistemology, from an analytic philosophical perspective.
Existential Eroticism: A Feminist Approach to Understanding Womens Oppression-Perpetuating Choices offer a unique lens aimed at the underbelly of the lady through which feminists can reorient discourses on rationality and moral responsibility related to women's oppression-perpetuating choices. Shay Welch utilizes feminist ethics, broadly construed as feminist philosophy concerned with the ethical commitment to eliminate oppression, to scrutinize how women regard and judge one another and to offer a more representative account of restriction, rationality, and responsibility to begin the healing process between diverse and divergent women. The book aims not only to construct an analysis of self-perpetuated oppression that will broaden feminist understandings of experiences that motivate many women to choose as they do, it serves as a means of understanding the marginalized.
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