Bøger udgivet af Cold Spring Harbor Laboratory Press,U.S.

Written and edited by experts in the field, this collection provides a comprehensive update on our understanding of the biological basis of and treatment strategies for addiction to psychoactive drugs, with an emphasis on opioids. Contributors examine the molecular targets of alcohol, cannabinoids, nicotine, stimulants, and opioids, the resulting changes to the neurocircuitry, and various genetic, environmental, developmental, and behavioral factors that influence the progression from abuse to addiction and susceptibility to relapse.

Influenza is a serious disease that affects millions worldwide every year. This book discusses cutting edge research on the viruses that cause the disease, its effects on the host, and current vaccine design strategies.

This collection captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology describes recent progress in our understanding of early heart development and the various cell lineages involved, as well as mechanisms and models of congenital heart disease. The contributors discuss early cardiac morphogenesis and anatomy, the origins of contractile activity, the control of cardiac growth and size, and the signaling pathways and transcription programs that underpin these processes. Specific chapters are devoted to various muscle and non-muscle cell lineages involved in heart development, including those of the neural crest, endo- and epicardium, fibroblasts, coronary vessels, and cardiac conduction and lymphatic systems.

Henri Termeer was one of the first of a pioneering group of business executives who built a disparate group of fledgling companies into a biotech industry that has driven decades of therapeutic innovation. In Conscience and Courage, John Hawkins, an insightful analyst of healthcare leaders, reveals the philosophy, principles, methods, and habits of a prominent and successful CEO who defied convention to create an investor-owned global enterprise that put people before profits and improved the lives of thousands of forgotten patients.

Written and edited by experts in the field, this collection examines recent progress in our understanding of stem cell biology and how the properties of stem cells can be manipulated for therapeutic purposes, emphasizing the roles that cutting-edge technologies and interdisciplinary approaches have played in this work. The contributors describe how the first cell lineages arise in the mammalian embryo, stem cell dynamics during the development and homeostasis of specific tissues, and what happens when stem cell integrity is compromised. They also explore specialized niches in which stem cells reside and how the extracellular cues in those microenvironments regulate stem cell behavior.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on all facets of calcium signaling. The contributors discuss the components and activities of the various calcium-sequestering organelles inside cells, the dynamic interactions that lead to spatiotemporally distinct signals in different circumstances, and the downstream effector mechanisms that translate the signals into biological outcomes. Recent advances in the field (e.g., structural insights into the functions of certain calcium channels) are emphasized throughout.

Written and edited by experts in the field, this collection provides a comprehensive update on the cell signaling that underlies the main cell death programs (apoptosis, pyroptosis, and necroptosis) and how this knowledge is driving the development of therapeutic drugs to treat some human diseases. Contributors describe in detail the molecular mechanisms of cell death signaling and the myriad players involved, including death receptor-ligand systems, BCL-2 family proteins, caspases, inflammasomes, gasdermin, MLKL, RIPK1, A20, and XIAP.

Written and edited by experts in the field, this collection covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells.

This collection captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of PTEN biology and its roles in human diseases. The contributors discuss the structural characteristics of PTEN; its functions at the plasma membrane as well as in the cytoplasm and nucleus; the mutations, interacting partners, and posttranslational modifications that affect its expression levels, subcellular localization, and enzymatic activity; and how this activity ultimately leads to changes in cell growth, migration, and morphology, as well as in gene expression, chromatin dynamics, and the maintenance of genomic stability. A historical perspective that covers the initial discovery and subsequent characterization of PTEN is also included.

Written and edited by experts in the field, this collection covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. The contributors review the normal functions of hematopoietic stem cells--the precursors to white blood cells--and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g., MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma.

Written and edited by experts in the field, this collection examines all aspects of the biology of HCV, the pathological consequences of infection, the current standard of hepatitis C treatment, and ongoing efforts to control the disease. Contributors discuss the structural and biochemical properties of HCV, the molecular details of its life cycle, and how it promotes liver disease by perturbing host cell signaling pathways. They likewise examine the innate and adaptive immune responses elicited by HCV and why those responses often fail to clear the infection.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the molecular bases of different plant characteristics and how they can be manipulated genetically using modern molecular biological techniques. The contributors review recent advances in our understanding of plant plasticity, circadian rhythms, stomatal development, inflorescence architecture, symbiotic phosphate acquisition, and specialized plant metabolism and discuss how this knowledge might be used to boost yields, improve tolerance to pathogens and environmental stress, and enhance nutritional content. Several chapters are devoted to the development of specific genetically modified plants (e.g., disease-resistant cassava and submergence-tolerant rice) and their agronomic and socioeconomic impacts.

Written and edited by experts in the field, this volume covers many aspects of bioelectronic medicine, examining the neuronal pathways that are being targeted for manipulation, the electronic neuromodulation devices that are under development, and how all of this work is leading to new diagnostics and treatment options for patients. The contributors discuss how the stimulation of specific nerves has been successfully used to treat certain conditions and how similar strategies are being investigated as therapeutics for a multitude of gastrointestinal, cardiovascular, respiratory, and renal disorders.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity).

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids).

Bone plays far more than just a structural role in our bodies. It actively communicates with our brains and other organs, releasing and responding to signaling molecules that regulate numerous biological processes. This book reviews the classical functions of bone as well as exciting new work that has revealed novel aspects of its biology.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines our current understanding of all aspects of protein synthesis and its control. The contributors describe recent insights into the fundamental steps in translation (initiation, elongation, termination, and ribosome recycling) based on high-resolution structures of the translational machinery. The signaling pathways and targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) are discussed, as are the roles of riboswitches, processing bodies (P-bodies), stress granules, and various classes of RNAs (e.g., circular RNAs). Methods to study translation dynamics, including ribosome profiling, kinetic assays, and single-molecule and single-cell fluorescence imaging, are also covered.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the pathogenesis and treatment of prostate cancer. The contributors review the normal development, anatomy, and histology of the prostate; the genetic, lifestyle, and dietary factors associated with prostate cancer risk; and the alterations in the genome, epigenetic landscape, transcriptional networks, and metabolic and signaling pathways that drive oncogenesis. The role of the tumor microenvironment in prostate cancer pathogenesis is covered, as are the molecular mechanisms of metastasis. The authors also discuss how mouse models and patient-derived tissues can be used to study aspects of the disease and accelerate the development of appropriate therapies.

Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord. The immune system attacks the myelin sheaths that surround and insulate nerve cells, producing a variety of neurological symptoms. This book examines the molecular basis of the condition, the nature of the autoimmune response, and current treatment and vaccine strategies.

Science is no quiet life. Imagination, creativity, ambition, and conflict are as vital and abundant in science as in artistic endeavors. In this collection of essays, the Nobel Prize-winning protein chemist Max Perutz writes about the pursuit of scientific knowledge, which he sees as an enterprise providing not just new facts but cause for reflection and revelation, as in a poem or painting. Max Perutz's essays explore a remarkable range of scientific topics with the lucidity and precision Perutz brought to his own pioneering work in protein crystallography. He has been hailed as an author who "makes difficult subjects intelligible and writes with the warmth, humanity, and broad culture which has always characterized the great men of science." Of his previous collection of essays, a reviewer said "They turn the world of science and medicine into a marvelous land of adventure which I was thrilled to explore in the company of this wise and human [writer]." Readers of this volume can journey to the same land, with the same delight. Max Perutz (1914-2002) was a brilliant scientist, a visionary of molecular biology, and a writer of elegant essays infused with humanity and wisdom. This expanded paperback edition of his very successful book I Wish I'd Made You Angry Earlier contains nine additional essays, and a warmly evocative portrait of Max by his friend and professional colleague Sir John Meurig Thomas. The original hardcover edition of this book was co-published with Oxford University Press. A paperback edition is also available from Oxford University Press. The expanded paperback edition is only available from Cold Spring Harbor Laboratory Press.