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Learn the data skills necessary for turning large sequencing datasets into reproducible and robust biological findings. With this practical guide, youll learn how to use freely available open source tools to extract meaning from large complex biological data sets.At no other point in human history has our ability to understand lifes complexities been so dependent on our skills to work with and analyze data. This intermediate-level book teaches the general computational and data skills you need to analyze biological data. If you have experience with a scripting language like Python, youre ready to get started.Go from handling small problems with messy scripts to tackling large problems with clever methods and toolsProcess bioinformatics data with powerful Unix pipelines and data toolsLearn how to use exploratory data analysis techniques in the R languageUse efficient methods to work with genomic range data and range operationsWork with common genomics data file formats like FASTA, FASTQ, SAM, and BAMManage your bioinformatics project with the Git version control systemTackle tedious data processing tasks with with Bash scripts and Makefiles

Tired of reading HTML books that only make sense after you're an expert? Then it's about time you picked up Head First HTML and really learned HTML. You want to learn HTML so you can finally create those web pages you've always wanted, so you can communicate more effectively with friends, family, fans, and fanatic customers. You also want to do it right so you can actually maintain and expand your web pages over time so they work in all browsers and mobile devices. Oh, and if you've never heard of CSS, that's okay--we won't tell anyone you're still partying like it's 1999--but if you're going to create web pages in the 21st century then you'll want to know and understand CSS.Learn the real secrets of creating web pages, and why everything your boss told you about HTML tables is probably wrong (and what to do instead). Most importantly, hold your own with your co-worker (and impress cocktail party guests) when he casually mentions how his HTML is now strict, and his CSS is in an external style sheet.With Head First HTML, you'll avoid the embarrassment of thinking web-safe colors still matter, and the foolishness of slipping a font tag into your pages. Best of all, you'll learn HTML and CSS in a way that won't put you to sleep. If you've read a Head First book, you know what to expect: a visually-rich format designed for the way your brain works. Using the latest research in neurobiology, cognitive science, and learning theory, this book will load HTML and CSS into your brain in a way that sticks.So what are you waiting for? Leave those other dusty books behind and come join us in Webville. Your tour is about to begin.

Get a comprehensive, in-depth introduction to the core Python language with this hands-on book. Based on author Mark Lutzs popular training course, this updated fifth edition will help you quickly write efficient, high-quality code with Python. Its an ideal way to begin, whether youre new to programming or a professional developer versed in other languages.Complete with quizzes, exercises, and helpful illustrations, this easy-to-follow, self-paced tutorial gets you started with both Python 2.7 and 3.3 the latest releases in the 3.X and 2.X linesplus all other releases in common use today. Youll also learn some advanced language features that recently have become more common in Python code.Explore Pythons major built-in object types such as numbers, lists, and dictionariesCreate and process objects with Python statements, and learn Pythons general syntax modelUse functions to avoid code redundancy and package code for reuseOrganize statements, functions, and other tools into larger components with modulesDive into classes: Pythons object-oriented programming tool for structuring codeWrite large programs with Pythons exception-handling model and development toolsLearn advanced Python tools, including decorators, descriptors, metaclasses, and Unicode processing

Pick up where certification exams leave off. With this practical, in-depth guide to the entire network infrastructure, youll learn how to deal with real Cisco networks, rather than the hypothetical situations presented on exams like the CCNA. Network Warrior takes you step by step through the world of routers, switches, firewalls, and other technologies based on the author's extensive field experience. You'll find new content for MPLS, IPv6, VoIP, and wireless in this completely revised second edition, along with examples of Cisco Nexus 5000 and 7000 switches throughout.Topics include:An in-depth view of routers and routingSwitching, using Cisco Catalyst and Nexus switches as examplesSOHO VoIP and SOHO wireless access point design and configurationIntroduction to IPv6 with configuration examplesTelecom technologies in the data-networking world, including T1, DS3, frame relay, and MPLSSecurity, firewall theory, and configuration, as well as ACL and authenticationQuality of Service (QoS), with an emphasis on low-latency queuing (LLQ)IP address allocation, Network Time Protocol (NTP), and device failures

Want to know how to use an electronic component? This second book of a three-volume set includes key information on electronics parts for your projects - complete with photographs, schematics, and diagrams. You'll learn what each one does, how it works, why it's useful, and what variants exist.

Written by members of Cisco's Computer Security Incident Response Team, this book shows IT and information security professionals how to create an InfoSec playbook by developing strategy, technique, and architecture.

Machine learning has become an integral part of many commercial applications and research projects, but this field is not exclusive to large companies with extensive research teams. If you use Python, even as a beginner, this book will teach you practical ways to build your own machine learning solutions.

"e;The computer world is like an intellectual Wild West, in which you can shoot anyone you wish with your ideas, if you're willing to risk the consequences. "e; --from Hackers & Painters: Big Ideas from the Computer Age, by Paul GrahamWe are living in the computer age, in a world increasingly designed and engineered by computer programmers and software designers, by people who call themselves hackers. Who are these people, what motivates them, and why should you care?Consider these facts: Everything around us is turning into computers. Your typewriter is gone, replaced by a computer. Your phone has turned into a computer. So has your camera. Soon your TV will. Your car was not only designed on computers, but has more processing power in it than a room-sized mainframe did in 1970. Letters, encyclopedias, newspapers, and even your local store are being replaced by the Internet.Hackers & Painters: Big Ideas from the Computer Age, by Paul Graham, explains this world and the motivations of the people who occupy it. In clear, thoughtful prose that draws on illuminating historical examples, Graham takes readers on an unflinching exploration into what he calls "e;an intellectual Wild West."e;The ideas discussed in this book will have a powerful and lasting impact on how we think, how we work, how we develop technology, and how we live. Topics include the importance of beauty in software design, how to make wealth, heresy and free speech, the programming language renaissance, the open-source movement, digital design, internet startups, and more.

Tap into the wisdom of experts to learn what every programmer should know, no matter what language you use. With the 97 short and extremely useful tips for programmers in this book, you'll expand your skills by adopting new approaches to old problems, learning appropriate best practices, and honing your craft through sound advice.With contributions from some of the most experienced and respected practitioners in the industry--including Michael Feathers, Pete Goodliffe, Diomidis Spinellis, Cay Horstmann, Verity Stob, and many more--this book contains practical knowledge and principles that you can apply to all kinds of projects.A few of the 97 things you should know:"e;Code in the Language of the Domain"e; by Dan North"e;Write Tests for People"e; by Gerard Meszaros"e;Convenience Is Not an -ility"e; by Gregor Hohpe"e;Know Your IDE"e; by Heinz Kabutz"e;A Message to the Future"e; by Linda Rising"e;The Boy Scout Rule"e; by Robert C. Martin (Uncle Bob)"e;Beware the Share"e; by Udi Dahan

Explains how to set up and use a home chemistry lab, with step-by-step instructions for conducting experiments in basic chemistry. This book shows how to do real lab work: purify alcohol by distillation; produce hydrogen and oxygen gas by electrolysis; smelt metallic copper from copper ore you make yourself; and much more.

As data continues to grow and become more complex, organizations seek innovative solutions to manage their data effectively. Data Mesh is one solution that provides a new approach to managing data in complex organizations. This practical guide offers step-by-step guidance on how to implement data mesh in your organization. In this book, Jean-Georges Perrin and Eric Broda focus on the key components of data mesh and provide practical advice supported by code. You'll explore a simple and intuitive process for identifying key data mesh components and data products, and learn about a consistent set of interfaces and access methods that make data products easy to consume. This approach ensures that your data products are easily accessible and the data mesh ecosystem is easy to navigate. With this book, you'll learn how to: Identify, define, and build data products that interoperate within an enterprise data mesh Build a data mesh fabric that binds data products together Build and deploy data products in a data mesh Establish the organizational structure to operate data products, data platforms, and data fabric Learn an innovative architecture that brings data products and data fabric together into the data mesh About the authors: Jean-Georges "JG" Perrin is a technology leader focusing on building innovative and modern data platforms. Eric Broda is a technology executive, practitioner, and founder of a boutique consulting firm that helps global enterprises realize value from data.

Whether youre a startup founder trying to disrupt an industry or an intrapreneur trying to provoke change from within, your biggest challenge is creating a product people actually want. Lean Analytics steers you in the right direction.This book shows you how to validate your initial idea, find the right customers, decide what to build, how to monetize your business, and how to spread the word. Packed with more than thirty case studies and insights from over a hundred business experts, Lean Analytics provides you with hard-won, real-world information no entrepreneur can afford to go without.Understand Lean Startup, analytics fundamentals, and the data-driven mindsetLook at six sample business models and how they map to new ventures of all sizesFind the One Metric That Matters to youLearn how to draw a line in the sand, so youll know its time to move forwardApply Lean Analytics principles to large enterprises and established products

In this book, author Will Larson shows you ways to obtain your first executive job and quickly ramp up to meet the challenges you may not have encountered in non-executive roles.

Together, the Flutter open source UI software development kit and the Dart programming language for client development provide a unified solution to building applications capable of targeting multiple platforms. Recipes in this cookbook show you how this potent combination provides an efficient approach to application development.

Master the math needed to excel in data science, machine learning, and statistics. In this book author Thomas Nield guides you through areas like calculus, probability, linear algebra, and statistics and how they apply to techniques like linear regression, logistic regression, and neural networks. Along the way you'll also gain practical insights into the state of data science and how to use those insights to maximize your career.Learn how to:Use Python code and libraries like SymPy, NumPy, and scikit-learn to explore essential mathematical concepts like calculus, linear algebra, statistics, and machine learningUnderstand techniques like linear regression, logistic regression, and neural networks in plain English, with minimal mathematical notation and jargonPerform descriptive statistics and hypothesis testing on a dataset to interpret p-values and statistical significanceManipulate vectors and matrices and perform matrix decompositionIntegrate and build upon incremental knowledge of calculus, probability, statistics, and linear algebra, and apply it to regression models including neural networksNavigate practically through a data science career and avoid common pitfalls, assumptions, and biases while tuning your skill set to stand out in the job market

Data engineering has grown rapidly in the past decade, leaving many software engineers, data scientists, and analysts looking for a comprehensive view of this practice. With this practical book, you'll learn how to plan and build systems to serve the needs of your organization and customers by evaluating the best technologies available through the framework of the data engineering lifecycle.Authors Joe Reis and Matt Housley walk you through the data engineering lifecycle and show you how to stitch together a variety of cloud technologies to serve the needs of downstream data consumers. You'll understand how to apply the concepts of data generation, ingestion, orchestration, transformation, storage, and governance that are critical in any data environment regardless of the underlying technology.This book will help you:Get a concise overview of the entire data engineering landscapeAssess data engineering problems using an end-to-end framework of best practicesCut through marketing hype when choosing data technologies, architecture, and processesUse the data engineering lifecycle to design and build a robust architectureIncorporate data governance and security across the data engineering lifecycle

Snowflake's ability to eliminate data silos and run workloads from a single platform creates opportunities to democratize data analytics, allowing users within an organization to make data-driven decisions. This clear, comprehensive guide will show you how to build integrated data applications and develop new revenue streams based on data.

This guide teaches Rust using a single small, complete, focused program in each chapter. Author Ken Youens-Clark shows you how to start, write, and test each of these programs to create a finished product. You'll learn how to handle errors in Rust, read and write files, and use regular expressions, Rust types, structs, and more.

Three acknowledged experts in search engine optimization share guidelines and innovative techniques that will help you plan and execute a comprehensive SEO strategy. Complete with an array of effective tactics from basic to advanced, this fourth edition prepares digital marketers for 2022 and beyond with updates on SEO tools and new search engine optimization methods that have reshaped the SEO landscape. Novices will receive a thorough SEO education, while experienced SEO practitioners get an extensive reference to support ongoing engagements. Learn about the various intricacies and complexities of internet search Explore the underlying theory and inner workings of search engines and their algorithms Understand the interplay between social media engagement and other factors Discover tools to track results and measure success Examine the effects of key Google algorithm updates Consider opportunities for visibility in mobile, local, vertical, social, and voice search Build a competent SEO team with defined roles Gain insights into the future of search and internet discoverability

If you use SQL in your day-to-day work as a data analyst, data scientist, or data engineer, this popular pocket guide is your ideal on-the-job reference. You'll find many examples that address the language's complexities, along with key aspects of SQL used in Microsoft SQL Server, MySQL, Oracle Database, PostgreSQL, and SQLite.In this updated edition, author Alice Zhao describes how these database management systems implement SQL syntax for both querying and making changes to a database. You'll find details on data types and conversions, regular expression syntax, window functions, pivoting and unpivoting, and more.Quickly look up how to perform specific tasks using SQLApply the book's syntax examples to your own queriesUpdate SQL queries to work in five different database management systems NEW: Connect Python and R to a relational databaseNEW: Look up frequently asked SQL questions in the "e;How Do I?"e; chapter

Learn how to use Autodesk Fusion 360 to digitally model your own original projects for a 3D printer or a CNC device.

How do you use PowerShell to navigate the filesystem, manage files and folders, or retrieve a web page? This introduction to the PowerShell language and scripting environment provides more than 400 task-oriented recipes to help you solve all kinds of problems. Intermediate to advanced system administrators will find more than 100 tried-and-tested scripts they can copy and use immediately.Updated for PowerShell 5.1 and Open Source PowerShell up to 7.0 and beyond, this comprehensive cookbook includes hands-on recipes for common tasks and administrative jobs that you can apply whether you're on the client or server version of Windows. You also get quick references to technologies used in conjunction with PowerShell, including regular expressions, the XPath language, format specifiers, and frequently referenced .NET, COM, and WMI classes.Learn how to use PowerShell on Windows 10 and Windows Server 2019Tour PowerShell's core features, including the command model, object-based pipeline, and ubiquitous scriptingMaster fundamentals such as the interactive shell, pipeline, and object conceptsPerform common tasks that involve working with files, internet-connected scripts, user interaction, and moreSolve tasks in systems and enterprise management, such as working with Active Directory and the filesystem

Written by two experienced systems programmers, this book explains how Rust manages to bridge the gap between performance and safety, and how you can take advantage of it.

Algorithmic trading, once the exclusive domain of institutional players, is now open to small organizations and individual traders using online platforms. The tool of choice for many traders today is Python and its ecosystem of powerful packages. In this practical book, author Yves Hilpisch shows students, academics, and practitioners how to use Python in the fascinating field of algorithmic trading.You'll learn several ways to apply Python to different aspects of algorithmic trading, such as backtesting trading strategies and interacting with online trading platforms. Some of the biggest buy- and sell-side institutions make heavy use of Python. By exploring options for systematically building and deploying automated algorithmic trading strategies, this book will help you level the playing field.Set up a proper Python environment for algorithmic tradingLearn how to retrieve financial data from public and proprietary data sourcesExplore vectorization for financial analytics with NumPy and pandasMaster vectorized backtesting of different algorithmic trading strategiesGenerate market predictions by using machine learning and deep learningTackle real-time processing of streaming data with socket programming toolsImplement automated algorithmic trading strategies with the OANDA and FXCM trading platforms

The new edition of this cookbook applies a highly practical approach to Structured Query Language (SQL) so you can create and manipulate large stores of data. Based on real-world examples, this updated book provides a framework to help you construct solutions and executable examples in several flavors of SQL

The future will be increasingly distributed. As the publicity surrounding Bitcoin and blockchain has shown, distributed technology and business models are gaining popularity. Yet the disruptive potential of this technology is often obscured by hype and misconception. This detailed guide distills the complex, fast moving ideas behind blockchain into an easily digestible reference manual, showing what's really going on under the hood.Finance and technology pros will learn how a blockchain works as they explore the evolution and current state of the technology, including the functions of cryptocurrencies and smart contracts. This book is for anyone evaluating whether to invest time in the cryptocurrency and blockchain industry. Go beyond buzzwords and see what the technology really has to offer.Learn why Bitcoin was fundamentally important in blockchain's birthExplore altcoin and alternative blockchain projects to understand what's possibleUnderstand the challenges of scaling and forking a blockchainLearn what Ethereum and other blockchains offerExamine emerging business uses for blockchain beyond cryptocurrencyDiscover where the future lies in this exciting new technology

Your team will change whether you like it or not. People will come and go. Your company might double in size or even be acquired. In this practical book, author Heidi Helfand shares techniques for reteaming effectively. Engineering leaders will learn how to catalyze team change to reduce the risk of attrition, learning and career stagnation, and the development of knowledge silos.Based on research into well-known software companies, the patterns in this book help CTOs and team managers effectively integrate new hires into an existing team, manage a team that has lost members, or deal with unexpected change. Youll learn how to isolate teams for focused innovation, rotate team members for knowledge sharing, break through organizational apathy, and more.Youll explore:Real-world examples that demonstrate why and how organizations reteamFive reteaming patterns: One by One, Grow and Split, Isolation, Merging, and SwitchingTactics to help you master dynamic reteaming in your companyStories that demonstrate problems caused by reteaming anti-patterns

For nearly 25 years this best seller has been the go-to guide for JavaScript programmers. The seventh edition is fully updated to cover the 2020 version of JavaScript, and new chapters cover classes, modules, iterators, generators, Promises, async/await, and metaprogramming.

This practical, user-friendly reference book of common mechanical engineering concepts is geared (no pun intended) toward makers who don't have (or want) an engineering degree but need to know the essentials of basic mechanical elements to successfully accomplish their personal projects.

With this practical guide, Harry Percival and Bob Gregory from MADE.com introduce proven architectural design patterns to help Python developers manage application complexity.