Bøger udgivet af Springer Basel

Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease.

The book begins at the level of an undergraduate student assuming only basic knowledge of calculus in one variable. It rigorously treats topics such as multivariable differential calculus, Lebesgue integral, vector calculus and differential equations. After having built on a solid foundation of topology and linear algebra, the text later expands into more advanced topics such as complex analysis, differential forms, calculus of variations, differential geometry and even functional analysis. Overall, this text provides a unique and well-rounded introduction to the highly developed and multi-faceted subject of mathematical analysis, as understood by a mathematician today.

The discovery of quantum mechanics in the years 1925-1930 necessitated the consideration of associating ordinary functions with non-commuting operators. Methods were proposed by Born/Jordan, Kirkwood, and Weyl. Sometime later, Moyal saw the connection between the Weyl rule and the Wigner distribution, which had been proposed by Wigner in 1932 as a way of doing quantum statistical mechanics. The basic idea of associating functions with operators has since been generalized and developed to a high degree. It has found several application fields, including quantum mechanics, pseudo-differential operators, time-frequency analysis, quantum optics, wave propagation, differential equations, image processing, radar, and sonar. This book aims at bringing together the results from the above mentioned fields in a unified manner and showing the reader how the methods have been applied. A wide audience is addressed, particularly students and researchers who want to obtain an up-to-date working knowledge of the field. The mathematics is accessible to the uninitiated reader and is presented in a straightforward manner.

This book provides a useful text for research students and scientists on the latest knowledge about the immune system of fish, cutting edge technologies and the step required to develop, test and commercialise fish vaccines.

In recent years there have been a number of significant developments of natural products for the treatment of rheumatic diseases, pain and gastro-intestinal ulcers and inflammation. Some of the natural products covered are either at the experimental stage of development while others are well-established clinically-used products.

The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008.

Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus.

In 1898 Camillo Golgi reported his newly observed intracellular structure, the apparato reticolare interno, now universally known as the Golgi Apparatus.

Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA.

Reprint from Pure and Applied Geophysics (PAGEOPH), Volume 151 (1998), No. 2/3/4

This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions.

The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states.

This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates.

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.

Die Bauwerksvermessung bildet die Grundlage für jede gründliche Bestandserfassung eines Gebäudes, seiner konstruktiven Zusammenhänge, des Bauzustandes und zu planende Baumaßnahmen. Sie erfasst das Bauwerk in seiner komplexen Form in einer angemessenen Detaillierung und bei Bedarf auch verformungsgetreu. Sie ist ein wesentlicher Bestandteil der Bauaufnahme im Rahmen von Sanierung, Modernisierung bzw. Umnutzung eines Gebäudes, aber auch bei Bauuntersuchungen für wissenschaftliche Zwecke der Haus- und Bauforschung und bei denkmalpflegerischen Maßnahmen.Die Bauwerksvermessung vereint methodisch das Handaufmaß mit Geodäsie, Photogrammetrie und Laserscanning. Der Autor bietet einen umfassenden Überblick und Anwenderwissen zum Thema Bauwerksvermessung. Die grundlegenden Verfahren Handaufmaß, Geodäsie, Photogrammetrie und Laserscanning bilden neben dem Management von Messprodukten an Bauwerken den Schwerpunkt des Buches. Das Buch ist ebenso geeignet als Nachschlagewerk über die derzeit aktuellen Verfahren und Methoden.

Expanding from the classic use of immunosuppressants in transplantation and rejection, this current overview highlights their new roles in clinical medicine.

What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l

New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

Die Einsatzmöglichkeiten von Holz im Außenbereich sind vielfältig. Wesentliche Anwendungen sind Überdachungen von Freiräumen, Fassaden, Türme, Brücken, aber auch sogenannte kleine Holzbauwerke wie Balkone, Pergolen, Zäune und Palisaden. Dabei stellen Freibewitterung und zum Teil auch Erdkontakt hohe Belastungen für den Baustoff Holz dar. Die Schutzmöglichkeiten für das exponierte Holz und das Vermeiden von konstruktiven Fehlern und damit letztendlich von Schäden sind deshalb Schwerpunkte dieses Buches. Der Holzschutz wird hier im umfassenden Sinne gesehen: die Wahl der Holzart, die baukonstruktive Ausbildung, bei Erfordernis der chemische Schutz und eine schützende Oberflächenbehandlung. Bei der Einstufung der Bauteile in Gefährdungsklassen, bei der Einordnung der Holzarten nach ihrer Dauerhaftigkeit und der Erfordernis oder besser Nichterfordernis eines chemischen Schutzes werden die Euro-Normen zugrunde gelegt und damit das aktuelle und zukünftige Regelwerk. Für die Beurteilung des Brandverhaltens und des Brandschutzes von Außenbauteilen wird die neue Musterbauordnung herangezogen, die dem Holzbau neue Möglichkeiten eröffnet. Zahlreiche Anwendungsbeispiele werden durch Fotos und Skizzen erläutert.