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Clustered survival data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public health and demography. Frailty models provide a powerful tool to analyse clustered survival data. In contrast to the large number of research publications on frailty models, relatively few statistical software packages contain frailty models.It is demanding for statistical practitioners and graduate students to grasp a good knowledge on frailty models from the existing literature. This book provides an in-depth discussion and explanation of the basics of frailty model methodology for such readers. The discussion includes parametric and semiparametric frailty models and accelerated failure time models. Common techniques to fit frailty models include the EM-algorithm, penalised likelihood techniques, Laplacian integration and Bayesian techniques. More advanced frailty models for hierarchical data are also included.Real-lifeexamples are used to demonstrate how particular frailty models can be fitted and how the results should be interpreted. The programs to fit all the worked-out examples in the book are available from the Springer website with most of the programs developed in the freeware packages R and Winbugs. The book starts with a brief overview of some basic concepts in classical survival analysis, collecting what is needed for the reading on the more complex frailty models.
Bayesian networks and decision graphs are formal graphical languages for representation and communication of decision scenarios requiring reasoning under uncertainty. Their strengths are two-sided. It is easy for humans to construct and to understand them, and when communicated to a computer, they can easily be compiled. Furthermore, handy algorithms are developed for analyses of the models and for providing responses to a wide range of requests such as belief updating, determining optimal strategies, conflict analyses of evidence, and most probable explanation. The book emphasizes both the human and the computer side. Part I gives a thorough introduction to Bayesian networks as well as decision trees and infulence diagrams, and through examples and exercises, the reader is instructed in building graphical models from domain knowledge. This part is self-contained and it does not require other background than standard secondary school mathematics. Part II is devoted to the presentation of algorithms and complexity issues. This part is also self-contained, but it requires that the reader is familiar with working with texts in the mathematical language. The author also: *Provides a well-founded practical introduction to Bayesian networks, decision trees and influence diagrams *Gives several examples and exercises exploiting the computer systems for Bayesian netowrks and influence diagrams *Gives practical advice on constructiong Bayesian networks and influence diagrams from domain knowledge. *Embeds decision making into the framework of Bayesian networks *Presents in detail the currently most efficient algorithms for probability updating in Bayesian networks *Discusses a wide range of analyes tools and model requests together with algorithms for calculation of responses. *Gives a detailed presentation of the currently most efficient algorithm for solving influence diagrams. Finn V. Jensen is professor of computer science at the University of Aalborg.
This is a history of parametric statistical inference, written by one of the most important historians of statistics of the 20th century, Anders Hald. This book can be viewed as a follow-up to his two most recent books, although this current text is much more streamlined and contains new analysis of many ideas and developments. And unlike his other books, which were encyclopedic by nature, this book can be used for a course on the topic, the only prerequisites being a basic course in probability and statistics.The book is divided into five main sections:* Binomial statistical inference;* Statistical inference by inverse probability;* The central limit theorem and linear minimum variance estimation by Laplace and Gauss;* Error theory, skew distributions, correlation, sampling distributions;* The Fisherian Revolution, 1912-1935.Throughout each of the chapters, the author provides lively biographical sketches of many of the main characters, including Laplace, Gauss, Edgeworth, Fisher, and Karl Pearson. He also examines the roles played by DeMoivre, James Bernoulli, and Lagrange, and he provides an accessible exposition of the work of R.A. Fisher.This book will be of interest to statisticians, mathematicians, undergraduate and graduate students, and historians of science.
Now in its second edition, this book continues to give readers a broad mathematical basis for modelling and understanding the wide range of wave phenomena encountered in modern applications. New and expanded material includes topics such as elastoplastic waves and waves in plasmas, as well as new exercises. Comprehensive collections of models are used to illustrate the underpinning mathematical methodologies, which include the basic ideas of the relevant partial differential equations, characteristics, ray theory, asymptotic analysis, dispersion, shock waves, and weak solutions. Although the main focus is on compressible fluid flow, the authors show how intimately gasdynamic waves are related to wave phenomena in many other areas of physical science. Special emphasis is placed on the development of physical intuition to supplement and reinforce analytical thinking. Each chapter includes a complete set of carefully prepared exercises, making this a suitable textbook for students in applied mathematics, engineering, and other physical sciences. Reviews of the first edition:"e;This book ... is an introduction to the theory of linear and nonlinear waves in fluids, including the theory of shock waves. ... is extraordinarily accurate and free of misprints ... . I enjoyed reading this book. ... most attractive and enticing appearance, and I'm certain that many readers who browse through it will wish to buy a copy. The exercises ... are excellent. ... A beginner who worked through these exercises would not only enjoy himself or herself, but would rapidly acquire mastery of techniques used...in JFM and many other journals..."e; (C. J. Chapman, Journal of Fluid Mechanics, Vol. 521, 2004) "e;The book targets a readership of final year undergraduates and first year graduates in applied mathematics. In the reviewer's opinion, it is very well designed to catch the student's interest ... while every chapter displays essential features in some important area of fluid dynamics. Additionally, students may practice by solving 91 exercises. This volume is mainly devoted to inviscid flows. ... The book is very well written."e; (Denis Serre, Mathematical Reviews, 2004)
The calculus of variations has a long history of interaction with other branches of mathematics such as geometry and differential equations, and with physics, particularly mechanics. More recently, the calculus of variations has found applications in other fields such as economics and electrical engineering. Much of the mathematics underlying control theory, for instance, can be regarded as part of the calculus of variations.This book is an introduction to the calculus of variations for mathematicians and scientists. The reader interested primarily in mathematics will find results of interest in geometry and differential equations. I have paused at times to develop the proofs of some of these results, and discuss briefly various topics not normally found in an introductory book on this subject such as the existence and uniqueness of solutions to boundary-value problems, the inverse problem, and Morse theory. I have made ¿passive use¿ of functional analysis (in particular normed vector spaces) to place certain results in context and reassure the mathematician that a suitable framework is available for a more rigorous study. For the reader interested mainly in techniques and applications of the calculus of variations, I leavened the book with numerous examples mostly from physics. In addition, topics such as Hamilton¿s Principle, eigenvalue approximations, conservation laws, and nonholonomic constraints in mechanics are discussed. More importantly, the book is written on two levels. The technical details for many of the results can be skipped on the initial reading. The student can thus learn the main results in each chapter and return as needed to the proofs for a deeper understanding.
The physics of semiconductors has seen an enormous evolution within the last ?fty years. Countless achievements have been made in scienti?c research and device applications have revolutionized everyday life. We have learned how to customize materials in order to tailor their optical as well as electronic properties. The on- ing trend toward device miniaturization has been the driving force on the appli- tion side and it has fertilized fundamental research. Nowadays, advanced processing techniques allow the fabrication of sub-micron semiconductor structures in many university research laboratories. At the same time, experiments down to millikelvin temperatures allow researchers to anticipate the observation of quantum phenomena, so far hidden at room temperature by the large thermal energy and strong dephasing. The ?eld of mesoscopic physics deals with systems under experimental con- tions where several quantum length scales for electrons such as system size and phase coherence length, or phase coherence length and elastic mean free path, are compa- ble. Intense research over the last twenty years has revealed an enormous richness of quantum effects in mesoscopic semiconductor physics, which is typically charact- ized by an interplay of quantum interference and many-body interactions. The most famous phenomena are probably the integer and fractional quantum Hall effects, the quantization of conductance through a quantum point contact, the Aharonov-Bohm effect, and single-electron charging of quantum dots.
Though there are many recent additions to graduate-level introductory books on Bayesian analysis, none has quite our blend of theory, methods, and ap plications. We believe a beginning graduate student taking a Bayesian course or just trying to find out what it means to be a Bayesian ought to have some familiarity with all three aspects. More specialization can come later. Each of us has taught a course like this at Indian Statistical Institute or Purdue. In fact, at least partly, the book grew out of those courses. We would also like to refer to the review (Ghosh and Samanta (2002b)) that first made us think of writing a book. The book contains somewhat more material than can be covered in a single semester. We have done this intentionally, so that an instructor has some choice as to what to cover as well as which of the three aspects to emphasize. Such a choice is essential for the instructor. The topics include several results or methods that have not appeared in a graduate text before. In fact, the book can be used also as a second course in Bayesian analysis if the instructor supplies more details. Chapter 1 provides a quick review of classical statistical inference. Some knowledge of this is assumed when we compare different paradigms. Following this, an introduction to Bayesian inference is given in Chapter 2 emphasizing the need for the Bayesian approach to statistics.
Introduction Some people distinguish between savings and investments, where savings are monies placed in relatively risk-free accounts with modest rewards, and where investments involve more risk and the potential for greater rewards. In this book we do not distinguish between these ideas. We treat them both under the umbrella of investing. In general, income falls into two categories: earned income¿which is the income derived from your everyday job¿andunearnedincome¿which is income derived from investing. You attend college to strengthen your prospects for earned income, so why do you need to worry about unearned income, namely, investment income? There are many reasons to invest and to learn about investing. Perhaps the primary one is to take charge of your own ?nancial future. You need money for short-term goals (such as living expenses, emergencies) and for long-term goals (such as buying a car, buying a house, educating children, paying catastrophic medical bills, funding retirement). Investing involvesborrowingandlending,andbuyingandselling. ¿ borrowing and lending. When you put money into a bank savings account,youarelendingyourmoneyandthebankisborrowingit.Youcan lend money to a bank, a business, a government, or a person. In exchange forthis,theborrowerpromisestopayyouinterestandtoreturnyourinitial investment at a future date. Why would the borrower do this? Because the borrower anticipates using this money in a way that earns more than the interest promised to you. Examples of borrowing and lending are savings accounts, certi?cates of deposits, money-market accounts, and bonds.
This book is an account of the theory of Hardy spaces in one dimension, with emphasis on some of the exciting developments of the past two decades or so. The last seven of the ten chapters are devoted in the main to these recent developments. The motif of the theory of Hardy spaces is the interplay between real, complex, and abstract analysis. While paying proper attention to each of the three aspects, the author has underscored the effectiveness of the methods coming from real analysis, many of them developed as part of a program to extend the theory to Euclidean spaces, where the complex methods are not available.
ThetheoryofstronglycontinuoussemigroupsoflinearoperatorsonBanach spaces, operator semigroups for short, has become an indispensable tool in a great number of areas of modern mathematical analysis. In our Springer Graduate Text [EN00] we presented this beautiful theory, together with many applications, and tried to show the progress made since the pub- cation in 1957 of the now classical monograph [HP57] by E. Hille and R. Phillips. However, the wealth of results exhibited in our Graduate Text seems to have discouraged some of the potentially interested readers. With the present text we o?er a streamlined version that strictly sticks to the essentials. We have skipped certain parts, avoided the use of sophisticated arguments,and,occasionally,weakenedtheformulationofresultsandm- i?ed the proofs. However, to a large extent this book consists of excerpts taken from our Graduate Text, with some new material on positive se- groups added in Chapter VI. We hope that the present text will help students take their ?rst step into this interesting and lively research ?eld. On the other side, it should provide useful tools for the working mathematician. Acknowledgments This book is dedicated to our students. Without them we would not be able to do and to enjoy mathematics. Many of them read previous versions when it served as the text of our Seventh Internet Seminar 2003/04. Here Genni Fragnelli, Marc Preunkert and Mark C. Veraar were among the most active readers. Particular thanks go to Tanja Eisner, Vera Keicher, Agnes Radl for proposing considerable improvements in the ?nal version.
This textbook illuminates the field of discrete mathematics with examples, theory, and applications of the discrete volume of a polytope. The authors have weaved a unifying thread through basic yet deep ideas in discrete geometry, combinatorics, and number theory. Because there is no other book that puts together all of these ideas in one place, this text is truly a service to the mathematical community. We encounter here a friendly invitation to the field of "e;counting integer points in polytopes,"e; also known as Ehrhart theory, and its various connections to elementary finite Fourier analysis, generating functions, the Frobenius coin-exchange problem, solid angles, magic squares, Dedekind sums, computational geometry, and more. With 250 exercises and open problems, the reader feels like an active participant, and the authors' engaging style encourages such participation. The many compelling pictures that accompany the proofs and examples add to the inviting style. This new edition will contain at least one new chapter, new exercises, many new references, corrections, important updates to the open problems, and some new, professionally done illustrationsFor teachers, this text is ideally suited as a capstone course for undergraduate students or as a compelling text in discrete mathematical topics for beginning graduate students. For scientists, this text can be utilized as a quick tooling device, especially for those who want a self-contained, easy-to-read introduction to these topics.
This book grew out of a one-semester course given by the second author in 2001 and a subsequent two-semester course in 2004-2005, both at the Univ- sity of Missouri-Columbia. The text is intended for a graduate student who has already had a basic introduction to functional analysis; the aim is to give a reasonably brief and self-contained introduction to classical Banach space theory. Banach space theory has advanced dramatically in the last 50 years and webelievethatthetechniquesthathavebeendevelopedareverypowerfuland should be widely disseminated amongst analysts in general and not restricted to a small group of specialists. Therefore we hope that this book will also prove of interest to an audience who may not wish to pursue research in this area but still would like to understand what is known about the structure of the classical spaces. Classical Banach space theory developed as an attempt to answer very natural questions on the structure of Banach spaces; many of these questions date back to the work of Banach and his school in Lvov. It enjoyed, perhaps, its golden period between 1950 and 1980, culminating in the de?nitive books by Lindenstrauss and Tzafriri [138] and [139], in 1977 and 1979 respectively. The subject is still very much alive but the reader will see that much of the basic groundwork was done in this period.
"e;PACS: A Guide to the Digital Revolution, Second Edition,"e; is a textbook of modern information sciences that fills an incredible need in the blossoming field of radiology. The emphasis is on a review of technological developments associated with the transition of radiology departments to filmless environments. As leaders in the field of computerized medical imaging, the editors and contributors provide insight into emerging technologies for physicians, administrators, and other interested groups. Each chapter addresses key topics in current literature with regard to the generation, transfer, interpretation, and distribution of images to the medical enterprise. This new edition has been updated to present recent developments in PACS, including: 1. An overview of the latest medical imaging standards; 2. A discussion of security issues as they relate to PACS, especially regarding HIPAA; 3. An introduction to current information on PACS workstations, including the impact of new software and hardware on radiologists; 4. An updated explanation of data storage and compression that highlights how advancements are applied; 5. A section on how PACS influences research and education, emphasizing how both educators and trainees are affected.Since health care organizations throughout the world are generating filmless implementation strategies, this exhaustive review is valued as a vital aid to leaders in the development of health care.
Many people think there is only one ¿right¿ way to teach geometry. For two millennia, the ¿right¿ way was Euclid¿s way, and it is still good in many respects. But in the 1950s the cry ¿Down with triangles!¿ was heard in France and new geometry books appeared, packed with linear algebra but with no diagrams. Was this the new ¿right¿ way, or was the ¿right¿ way something else again, perhaps transformation groups? In this book, I wish to show that geometry can be developed in four fundamentally different ways, and that all should be used if the subject is to be shown in all its splendor. Euclid-style construction and axiomatics seem the best way to start, but linear algebra smooths the later stages by replacing some tortuous arguments by simple calculations. And how can one avoid projective geometry? It not only explains why objects look the way they do; it also explains why geometry is entangled with algebra. Finally, one needs to know that there is not one geometry, but many, and transformation groups are the best way to distinguish between them. Two chapters are devoted to each approach: The ?rst is concrete and introductory, whereas the second is more abstract. Thus, the ?rst chapter on Euclid is about straightedge and compass constructions; the second is about axioms and theorems. The ?rst chapter on linear algebra is about coordinates; the second is about vector spaces and the inner product.
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