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Neuroimaging: Clinical and Physical Principles is destined to be the new benchmark among text/reference books for neuroradiology. Unique among all similar titles is this book's complete coverage of ALL imaging modalities and techniques used in modern neuroimaging, from MR (including up-to-the minute developments in fast MR, MRA, and FLAIR), to CT, ultrasonography, angiography, plain film, and myelography. Many topics that are covered little if at all in standard neuroimaging texts are given complete, state-of-the-art descriptions in this book, including: imaging of the head, neck, temporal bone, orbit, and sinuses; normal variants; imaging of pediatric neurologic diseases and developmental anomalies; imaging of trauma to the head, brain, and spine; interventional techniques, both intracranial and spinal; and sedation of both adult and pediatric patients. The book is rounded out with complete coverage of the Physical Principles that underlie modern Computed Tomography and Magnetic Resonance Imaging. The ten chapters in this section provide everything the radiologist must know such as; the physical basics of MR and CT; MR and CT contrast agents and their applications; hardware and safety issues; image acquisition and artifacts; and more! Each chapter is organized to provide fast answers to everyday clinical problems. Numerous tables and lists summarize imaging protocols and differential diagnoses for rapid reference, while the text of each chapter provides a thorough review of the state of the art neuroimaging procedures. Chapters reveal potential imaging findings for numerous conditions and direct the reader towards the imaging technique that will reveal the most informative results under each circumstance.

The young investigator with an idea has to negotiate many institutional, federal, and industrial challenges in order to get a product to market. Nowhere is described the steps in the development of new drugs, diagnos- tics, or devices; the person with an idea has nowhere to turn for information and details. The young investigator may understand the elements of basic and clinical research, but ordinarily has no insight into novel ways of finding research funding or how to explore to find the funding opportunities that are available. The young investigator has little knowledge of the mecha- nisms to bring an idea through the developmental phases to the market. There are other players in this complex endeavor with whom he or she has no contact, including those from industry, the Food and Drug Administration, and the legal community. Exposure to the philosophy of product develop- ment and to procedural information would be useful to the scientific com- munity, as would contact with those who have successfully taken an idea to a finished product. A first attempt to do this was the symposium on Idea to Product: The Process, sponsored by Serono Symposia USA and held No- vember 17 to 20, 1994, in Washington, D.C. This book comprises the pro- ceedings of that meeting. The editors are indebted to the many contributors to this volume, and we are especially grateful to Serono Symposia USA and to Leslie Nies and her staff for their expertise in organizing the symposium.

This book explores the remarkable connections between two domains that, a priori, seem unrelated: Random matrices (together with associated random processes) and integrable systems. The relations between random matrix models and the theory of classical integrable systems have long been studied. These appear mainly in the deformation theory, when parameters characterizing the measures or the domain of localization of the eigenvalues are varied. The resulting differential equations determining the partition function and correlation functions are, remarkably, of the same type as certain equations appearing in the theory of integrable systems. They may be analyzed effectively through methods based upon the Riemann-Hilbert problem of analytic function theory and by related approaches to the study of nonlinear asymptotics in the large N limit. Associated with studies of matrix models are certain stochastic processes, the "e;Dyson processes"e;, and their continuum diffusion limits, which govern the spectrum in random matrix ensembles, and may also be studied by related methods. Random Matrices, Random Processes and Integrable Systems provides an in-depth examination of random matrices with applications over a vast variety of domains, including multivariate statistics, random growth models, and many others. Leaders in the field apply the theory of integrable systems to the solution of fundamental problems in random systems and processes using an interdisciplinary approach that sheds new light on a dynamic topic of current research.

"e;Complex Intelligent Systems and Applications"e; presents the most up-to-date advances in complex, software intensive and intelligent systems. Each self-contained chapter is the contribution of distinguished experts in areas of research relevant to the study of complex, intelligent, and software intensive systems. These contributions focus on the resolution of complex problems from areas of networking, optimization and artificial intelligence. The book is divided into three parts focusing on complex intelligent network systems, efficient resource management in complex systems, and artificial data mining systems. Through the presentation of these diverse areas of application, the volume provides insights into the multidisciplinary nature of complex problems. Throughout the entire book, special emphasis is placed on optimization and efficiency in resource management, network interaction, and intelligent system design. This book presents the most recent interdisciplinary results in this area of research and can serve as a valuable tool for researchers interested in defining and resolving the types of complex problems that arise in networking, optimization, and artificial intelligence.

Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference. Our sincere thanks to the contributing authors for the time and effort they have devoted to writing what I consider exceptionally informative chapters in a book that will have a significant impact on the complement field. We would also like to express my thanks to Rodanthi Lambris for her assistance in collating the chapters and preparing the documents for publication and I gratefully acknowledge the generous help provided by Dimitrios Lambris in managing the organization of this meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her supervision in this book's production. John D. Lambris Anthony P.

Walter Gautschi has written extensively on topics ranging from special functions, quadrature and orthogonal polynomials to difference and differential equations, software implementations, and the history of mathematics. He is world renowned for his pioneering work in numerical analysis and constructive orthogonal polynomials, including a definitive textbook in the former, and a monograph in the latter area. This three-volume set, Walter Gautschi: Selected Works with Commentaries, is a compilation of Gautschi's most influential papers and includes commentaries by leading experts. The work begins with a detailed biographical section and ends with a section commemorating Walter's prematurely deceased twin brother. This title will appeal to graduate students and researchers in numerical analysis, as well as to historians of science. Selected Works with Commentaries, Vol. 1Numerical ConditioningSpecial FunctionsInterpolation and Approximation Selected Works with Commentaries, Vol. 2Orthogonal Polynomials on the Real LineOrthogonal Polynomials on the SemicircleChebyshev QuadratureKronrod and Other QuadraturesGauss-type Quadrature Selected Works with Commentaries, Vol. 3Linear Difference EquationsOrdinary Differential EquationsSoftwareHistory and BiographyMiscellaneaWorks of Werner Gautschi

Walter Gautschi has written extensively on topics ranging from special functions, quadrature and orthogonal polynomials to difference and differential equations, software implementations, and the history of mathematics. He is world renowned for his pioneering work in numerical analysis and constructive orthogonal polynomials, including a definitive textbook in the former, and a monograph in the latter area. This three-volume set, Walter Gautschi: Selected Works with Commentaries, is a compilation of Gautschi's most influential papers and includes commentaries by leading experts. The work begins with a detailed biographical section and ends with a section commemorating Walter's prematurely deceased twin brother. This title will appeal to graduate students and researchers in numerical analysis, as well as to historians of science. Selected Works with Commentaries, Vol. 1Numerical ConditioningSpecial FunctionsInterpolation and Approximation Selected Works with Commentaries, Vol. 2Orthogonal Polynomials on the Real LineOrthogonal Polynomials on the SemicircleChebyshev QuadratureKronrod and Other QuadraturesGauss-type Quadrature Selected Works with Commentaries, Vol. 3Linear Difference EquationsOrdinary Differential EquationsSoftwareHistory and BiographyMiscellaneaWorks of Werner Gautschi

Walter Gautschi has written extensively on topics ranging from special functions, quadrature and orthogonal polynomials to difference and differential equations, software implementations, and the history of mathematics. He is world renowned for his pioneering work in numerical analysis and constructive orthogonal polynomials, including a definitive textbook in the former, and a monograph in the latter area. This three-volume set, Walter Gautschi: Selected Works with Commentaries, is a compilation of Gautschi's most influential papers and includes commentaries by leading experts. The work begins with a detailed biographical section and ends with a section commemorating Walter's prematurely deceased twin brother. This title will appeal to graduate students and researchers in numerical analysis, as well as to historians of science. Selected Works with Commentaries, Vol. 1Numerical ConditioningSpecial FunctionsInterpolation and Approximation Selected Works with Commentaries, Vol. 2Orthogonal Polynomials on the Real LineOrthogonal Polynomials on the SemicircleChebyshev QuadratureKronrod and Other QuadraturesGauss-type Quadrature Selected Works with Commentaries, Vol. 3Linear Difference EquationsOrdinary Differential EquationsSoftwareHistory and BiographyMiscellaneaWorks of Werner Gautschi

Rates of childhood obesity are alarmingly high and increasing each year. Studies have shown that obese children are more likely to become obese adults and are likely to suffer with numerous health consequences like coronary heart disease, high blood pressure, and Type II diabetes, among others. Studies also indicate that television viewing and exposure to advertising for food products influences children's attitudes toward, food preferences and food purchase requests for foods with low nutritional value. It is important to better understand the role of media in childhood obesity and to learn how media may be used to address this issue in a positive way. This book focuses on communication and media research that can have an impact on reducing childhood obesity. Emphasis is placed on topics related to how the media communicate health-related messages about food, nutrition and diet that influence childhood obesity. Particular emphasis is on the new media, given the fact that media now have more central roles in socializing today's children and youth than ever before. Advertising and marketing messages reach young consumers through a variety of vehicles - broadcast and cable television, radio, magazines, computers through the Internet, music, cell phones - and in many different venues - homes, schools, child-care settings, grocery stores, shopping malls, theaters, sporting events, and even airports. In addition, given the disparity in obesity rates between children of color and the general population, special attention is given to research on media targeting these populations.

From the 39th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Washington, DC, USA in July 2011, this volume covers aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence. Oxygen Transport to Tissue XXXIV includes contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians.

These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics include: modularity and scalability; evolvability; human-competitive results; the need for important high-impact GP-solvable problems;; the risks of search stagnation and of cutting off paths to solutions; the need for novelty; empowering GP search with expert knowledge;In addition, GP symbolic regression is thoroughly discussed, addressing such topics as guaranteed reproducibility of SR; validating SR results, measuring and controlling genotypic complexity; controlling phenotypic complexity; identifying, monitoring, and avoiding over-fitting; finding a comprehensive collection of SR benchmarks, comparing SR to machine learning. This text is for all GP explorers. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.

This volume is the product of a February 1982 conference, cosponsored by the American Heart Association, the National Institutes of Health, and the Bowman Gray School of Medicine, which examined techniques for delineating quantitatively the natural history of atherosclerosis. Against the background of current pathologic and clinical knowledge of atherosclerosis, invasive and noninvasive evaluative methods now in use and under development are surveyed in depth. Correlative clinicopathologic studies of atherosclerosis pose special questions with respect to both luminal and plaque characteristics that are addressed in this volume. An old observa- tion, based on the examination of arterial casts, suggested that the so-called nodose lesion of atherosclerosis may be at first flattened into the wall of a weakened, dilated artery, rather than raised into the lumen. This is now fully confirmed in vivo by ultrasonic and other imaging techniques. The morbid anatomist is challenged anew to describe lesions as they are likely to occur in vivo. To achieve closer correlation with natural conditions, perfu- sion fixation of arteries under arterial pressure is becoming more widely used and has already demonstrated more valid quantita- tion of the composition and configuration of lesions. While the noninvasive methods of B-mode and Doppler ultrasound are suitable only for the clinical study of superficial arteries, such as the carotid or femoral, the new and relatively noninvasive procedure of intravenous digital subtraction angio- graphy can be effectively used for the examination of deep systems, such as cerebral vessels.

Signi?cant progress has been made in the development of neural prostheses for restoration of human functions and improvement of the quality of life. Biomedical engineers and neuroscientists around the world are working to improve the design and performance of existing devices and to develop novel devices for arti?cial vision, arti?cial limbs, and brain-machine interfaces. This book, Implantable Neural Prostheses 2: Techniques and Engineering Approaches, is part two of a two-volume sequence that describes state-of-the-art advances in techniques associated with implantable neural prosthetic devices. The techniques covered include biocompatibility and biostability, hermetic packaging, electrochemical techniques for neural stimulation applications, novel electrode materials and testing, thin-?lm ?exible microelectrode arrays, in situ char- terization of microelectrode arrays, chip-size thin-?lm device encapsulation, microchip-embedded capacitors and microelectronics for recording, stimulation, and wireless telemetry. The design process in the development of medical devices is also discussed. Advances in biomedical engineering, microfabrication technology, and neu- science have led to improved medical-device designs and novel functions. However, many challenges remain. This book focuses on the engineering approaches, R&D advances, and technical challenges of medical implants from an engineering p- spective. We are grateful to leading researchers from academic institutes, national laboratories, as well as design engineers and professionals from the medical device industry who have contributed to the book. Part one of this series covers designs of implantable neural prosthetic devices and their clinical applications.

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.

Recon?guring Disturbance, Succession, and Forest Management: The Science of Mount St. Helens When Mount St. Helens erupted on May 18, 1980, it did more than just recon?gure a large piece of Cascadian landscape. It also led to dramatic revisions in our perspectives on disturbances, secondary succession, and forestry practices. The Mount St. Helens landscape turned out to be a far more complex place than the "e;moonscape"e; that it initially appeared to be. Granted, a large area was literally scoured and sterilized, and that vast expanse of newly formed rock, mud?ows, and avalanche debris up and down the mountain made the Mount St. Helens landscape unique. But I still remember my surprise when, as I stepped out of the helicopter on ?rst landing within the extensive "e;devastated zone,"e; I saw hundreds of plants pushing their way up through the mantel of tephra. Surviving organisms were stunning in their diversity, abundance, and the mechanisms by which they survived. They persisted as whole organisms living below ground, encased within late-persisting snowbanks, and buried in lake and stream sediments. They survived as rhizomes transported along with the massive landslide that accompanied the eruption and as stems that suffered the abrasion of mud?ows. Mud?ows ?oated nurse logs covered with tree seedlings and then redeposited them on the ?oor of a forested river terrace. Millions, perhaps billions, of plants survived as rootstocks and rhizomes that pushed their way up through the tephra, and others survived on the bases of uprooted trees.

As arthroscopy becomes the gold standard of care in treating wrist problems, there is a vast need for an up-to-date practical guide on wrist arthroscopy. To fill that need, Dr. William Geissler has brought together an international group of eminent experts, who share their knowledge to present the full scope of all aspects of wrist arthroscopy. In 24 chapters, generously illustrated with over 300 images, 44 in full color, the book explores every clinically relevant aspect of wrist arthroscopy. This includes arthroscopic wrist anatomy and how to evaluate the painful wrist, arthroscopic management of carpal instability, fracture management, arthofibrosis, and arthroscopic tunnel release. Each chapter includes a brief overview followed by indications for the procedure and surgical techniques. In addition, the book features a section on tips and tricks and how to avoid common pitfalls.

Over the past decade there has been an explosion of developments in mixed e?ects models and their applications. This book concentrates on two major classes of mixed e?ects models, linear mixed models and generalized linear mixed models, with the intention of o?ering an up-to-date account of theory and methods in the analysis of these models as well as their applications in various ?elds. The ?rst two chapters are devoted to linear mixed models. We classify l- ear mixed models as Gaussian (linear) mixed models and non-Gaussian linear mixed models. There have been extensive studies in estimation in Gaussian mixed models as well as tests and con?dence intervals. On the other hand, the literature on non-Gaussian linear mixed models is much less extensive, partially because of the di?culties in inference about these models. However, non-Gaussian linear mixed models are important because, in practice, one is never certain that normality holds. This book o?ers a systematic approach to inference about non-Gaussian linear mixed models. In particular, it has included recently developed methods, such as partially observed information, iterative weighted least squares, and jackknife in the context of mixed models. Other new methods introduced in this book include goodness-of-?t tests, p- diction intervals, and mixed model selection. These are, of course, in addition to traditional topics such as maximum likelihood and restricted maximum likelihood in Gaussian mixed models.

From reviews of the first edition:"e;In the world of mathematics, the 1980's might well be described as the "e;decade of the fractal"e;. Starting with Benoit Mandelbrot's remarkable text The Fractal Geometry of Nature, there has been a deluge of books, articles and television programmes about the beautiful mathematical objects, drawn by computers using recursive or iterative algorithms, which Mandelbrot christened fractals. Gerald Edgar's book is a significant addition to this deluge. Based on a course given to talented high- school students at Ohio University in 1988, it is, in fact, an advanced undergraduate textbook about the mathematics of fractal geometry, treating such topics as metric spaces, measure theory, dimension theory, and even some algebraic topology...the book also contains many good illustrations of fractals (including 16 color plates)."e;Mathematics Teaching"e;The book can be recommended to students who seriously want to know about the mathematical foundation of fractals, and to lecturers who want to illustrate a standard course in metric topology by interesting examples."e;Christoph Bandt, Mathematical Reviews"e;...not only intended to fit mathematics students who wish to learn fractal geometry from its beginning but also students in computer science who are interested in the subject. Especially, for the last students the author gives the required topics from metric topology and measure theory on an elementary level. The book is written in a very clear style and contains a lot of exercises which should be worked out."e;H.Haase, ZentralblattAbout the second edition: Changes throughout the text, taking into account developments in the subject matter since 1990; Major changes in chapter 6. Since 1990 it has become clear that there are two notions of dimension that play complementary roles, so the emphasis on Hausdorff dimension will be replaced by the two: Hausdorff dimension and packing dimension. 6.1 will remain, but a new section on packing dimension will follow it, then the old sections 6.2--6.4 will be re-written to show both types of dimension; Substantial change in chapter 7: new examples along with recent developments; Sections rewritten to be made clearer and more focused.