Advances in Pharmacokinetics and Pharmacodynamics - Panos Macheras - Bog

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art inPhysiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development ofPhysiologically Based Finite Time Pharmacokinetic (PBFTPK) models and
their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 providesan overview of PK/PD modeling and simulation in clinical practice and
studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence ofclinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.