Bøger i Advances in Experimental Medic serien

This book presents the latest research on multisensory brain function. Namely, the mechanisms by which the brain processes and integrates information from multiple sensory modalities. Its contents cover a broad range of topics, including optimal integration, cross-modal interactions, calibration, and causal inference ¿ with an emphasis on their neuronal underpinnings. By bringing together efforts from different laboratories around the world we aim to collaboratively shed light on these fundamental brain processes, that underlie perception, cognition, and behavior in a complex multisensory world, and to spur innovation of brain-inspired technologies

This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.

This book focuses on both high-density lipoproteins (HDL) metabolism and related diseases from the perspectives of the world-class experts in HDL. Several chapters in this book provide the overall information about HDL metabolism via detailed discussion of HDL structures as well as several key molecules involved in its functions, such as SR-B1 and Cholesteryl Ester Transfer Protein Inhibitors and so on. The rest of this book illustrates the connection between HDL and several diseases that are the major concerns of people's health in many countries, and devotes to exploring the therapies of HDL related diseases. With a better understanding of the HDL metabolism and diseases, this book will benefit the audiences with interest in HDL from biomedicine to clinical practice.

This book aims to systemically summarize the key findings about Innate lymphoid cells (ILCs) and present the consensus of current views and prospective. ILCs are a class of newly recognized immune cells which play an instructive role in shaping immunity in physiological and pathological conditions. This book discusses the differentiation of ILC, the relation of ILCs with respiratory function, inflammation in the gut, skin disorders, cancer, neurobiology and microbes. The knowledge included in this book is valuable for both basic immunologists and clinicians in understanding the heterogenetic immune responses in disease and health.

This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.

This book focuses on the important discoveries of the small molecule-, peptide-, and protein-based virus entry inhibitors and discusses advance of the development of different type of virus entry inhibitors as a novel class of antiviral drugs for treatment and prevention of viral infection. It includes entry inhibitors of HIV,HeV, NiV, RSV, EBOV, HCoV, HBV, HCV, HDV, HPV, flavivirus and influenza virus, so on. This book aims at providing an updated knowledge on virus entry inhibitors.

This book reviews the research trends of cognitive aging and brain health from full-scale. It not only contains cognitive aging¿s neurophysiological mechanism, clinical research and intervention measures, but also covers cognitive aging¿s social psychological mechanism, such as the relation between old people¿s motion, socioeconomic status and the cognitive aging. Through decades of research and practice, the views towards the cognitive aging process havebeen transferred from coping with cognitive decline to promoting cognitive ability. This book provides with the latest research findings and in-depth opinions of the cognitive aging and brain health, assisting researchers to grasp the theories, practice and trends of this field, and guide health-care workers to carry out the treatment and nursing for the aged.

This book provides the latest research progress on Extracellular vesicles (EVs) in cardiovascular and metabolic diseases. EVs are small bilayer lipid membrane vesicles released by cells and function for intercellular communication. Increasing evidence has shown that EVs play crucial roles in cardiovascular and metabolic diseases, which seriously threaten human health worldwide. The book contains four sections: 1) Extraction Methods; 2) EVs in Cardiovascular Diseases; 3) EVs in Metabolic Diseases; and 4) Therapeutic Implications. This book is useful for biologists, cardiologists, cardiovascular surgeons, endocrinologists, internists, nurses, undergraduate and graduate students in medicine and cell biology, and others interested in cardiovascular and metabolic medicine.

This book systematically and comprehensively discusses the biological, epidemiological, and clinical characteristics of the hepatitis E virus (HEV). It presents current knowledge of HEV and explores experimental methods, treatment, and prevention of HEV. First identified in the 1980s and cloned in 1990, HEV is the causative agent of hepatitis E, which mainly occurs in developing regions, such as Southeast Asia, the Middle East, and Africa, and significantly affects the health of the people in these areas. It is estimated that a third of the world¿s population has been infected with HEV, which is transmitted via the fecal-oral route and can infect both humans and animals. In the second edition, new chapters are added to demonstrate the lifecycle, morphogenesis, and stem cell culture of hepatitis E virus. Although research on hepatitis E virus has made progress recently, there are still some problems that have not been solved. Those problems are discussed in this edition, which would be helpful for researchers to understand the problems on hepatitis E virus that they have faced. Meanwhile, the epidemiology, transmission, genetic evolution, animal models, treatment, and others in the related chapters of the first version were also updated according to the most recent research progress. The book provides an overview of HEV from benchside to bedside. It is a valuable resource for researchers in the field and those in the pharmaceutical industry developing HEV vaccines, as well as physicians involved in identifying and treating those infected with the virus.

The latest developments in the area of microbial immunity are explored and explained in this timely volume, including new conceptual frameworks for the processing and presentation of peptides and nonpeptide antigens from microbes to T cells. Such experimental models have been instrumental in defining some of the pathways for generating protective immune responses against microbes. Other topics covered include: DAP 12, CD4+, Th1 and Th2 Cells, HIV infection, fusion, and tropism, and vaccine development.

Basic Properties of the Actin Molecule and Actin-Based Microfilament Systems.- Vibrational Modes of G-Actin.- Combining Electron Microscopy and X-Ray Crystallography Data to Study the Structure of F-Actin and its Implications for Thin-Filament Regulation in Muscle.- Evidence for an F-Actin Like Conformation in the Actin: DNase I Complex.- Actin-Bound Nucleotide/Divalent Cation Interactions.- Influence of the High Affinity Divalent Cation on Actin Tryptophan Fluorescence.- C-Terminus on Actin: Spectroscopic and Immunochemical Examination of its Role in Actinomycin Interactions.- Actin Polymerization: Regulation by Divalent Metal Ion and Nucleotide Binding, ATP Hydrolysis and Binding of Myosin.- Actin-Associated Proteins and Control of Filament-Based Assembly-Disassembly.- Structural Requirements of Tropomyosin for Binding to Filamentous Actin.- Actin-Gelsolin Interaction.- Actin Regulation and Surface Catalysis.- Caldesmon: Possible Functions in Microfilament Reorganization During Mitosis and Cell Transformation.- Cytoskeleton, Motile Structures and Macromolecular Crowding.- Cellular Functions of the Microfilament System.- Actin Filament Dynamics in Cell Motility.- Changes in Adhesion Plaque Protein Levels Regulate Cell Motility and Tumorigenicity.- Induction of Collagen Synthesis in Response to Adhesion and TGF? is Dependent on the Actin-Containing Cytoskeleton.- Gelsolin Expression in Normal Human Keratinocytes is a Function of Induced Differentiation.- Actin Filaments and the Spatial Positioning of mRNA.- Redistribution of p52(PAI-l) mRNA to the Cytoskeletal Framework Accompanies Increased p52(PAI-l) Expression in Cytochalasin D-Stimulated Rat Kidney Cells.- Brush Border Myosin I Has a Calmodulin/Phosphatidylserine Switch and Tail Actin-Binding.- Control of p52(PAI-l) Gene Expression in Normal and Transformed Rat Kidney Cells: Relationship Between p52(PAI-l) Induction and Actin Cytoarchitecture.- Contributors

This book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells present in the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse physiological functions, including the secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling, especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, research on ion channels carries significant meaning for the understanding of basic protein biophysics and diverse physiological functions. Such vital information also assists in developing novel and effective treatments for related human diseases. This book provides graduates and scientists in both basic and clinical levels a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.

Section I: Controlled Fusion: Soon! (E. Teller). Comments on the Feasibility of Achieving Scientific Breakeven with a Plasma Focus Machine (J.S. Brzosko et al.). SelfColliding Beams as an Alternative Fusion System for DHe3 Reactors (N. Rostoker, M. Binderbauer). Target Physics for Inertial Fusion Energy (J.M. MartinezVal et al.). Spherical Pinch Research: Historical Background, Achievements, and Projections (F. Giammanco et al.). Section II: Perspectives of Advanced Confinement Programs (B. Coppi). Present Status of FieldReversed Configurations (J. Slough). Ignition Physics and the Ignitor Project (F. Pegoraro). The Inertial Electrostatic Confinement Approach to Fusion Power (G.H. Miley). The D3He Dipole Fusion Reactor (M.E. Mauel). OpenEnded Magnetic Confinement Systems for Fusion (R.F. Post, D.D. Ryutov). Formation, Compression, and Acceleration of Magnetized Plasmas (J.H. Degnan). Prospects of Magnetic Electrostatic Plasma Confinement (T.J. Dolan). Analysis of the Fusion Breakeven Conditions for DT Plasmas of Prescribed Temperature Evolution (E. Panarella). Section III: Progress in Inertial Fusion Research (C. Yamanaka). HeavyIon Driven Inertial Fusion Energy (R.O. Bangerter, T.J. Fessenden). XRay Driven Implosions on the Nova Laser (J.D. Kilkenny et al.). Present Status and Future Prospects of Laser Fusion Research at Osaka (C. Yamanaka). Magnetized Target Fusion: An Overview of the Concept (R.C. Kirkpatrick, M.A. Sweeney). Thermonuclear Fusion in a Staged Pinch (H.U. Rahman et al.). Novel Staged ZPinch Concept as a Super Radiant XRay Source for ICF (V.M. Bystritskii et al.). Section IV: Fusion, the Competition, and the Prospects for Alternative Fusion Concepts (L.J. Perkins et al.). Ideas for Future RFP Experiments (J.A. Phillips et al.). Dense ZPinches for Fusion (D. Scudder, J. Shlachter). Assessment of FieldReversedConfiguration Stability (R.E. Siemon). MuonCatalyzed Fusion in 1996 (S.E. Jones). Experimental Investigation of the Muon Catalyzed Fusion in Mixtures of Hydrogen Isotopes (V.M. Bystritsky). Magnetoelectric Toroidal Confinement (J.R. Roth). Ball Lightning: What Nature is Trying to Tell the Fusion Community (J.R. Roth). Fusion Implications of FreeFloating Plasmak(R) Magnetoplasmoids (P.M. Koloc). Section V: Alternate Fusion Concepts (N. Rostoker). Inertial Fusion Driven by Intense Cluster Ion Beams (C. Deutsch). Inertial Fusion Energy: An Approach to Low Maintenance and Cost of Electricity, and the Role of the National Ignition Facility Testing the Target Physics (B.G. Logan). Magnetized Target Fusion: An Ultrahigh Energy Approach in an Unexplored Parameter Space (R.C. Kirkpatrick et al.). Section VI: Concluding Remarks (E. Panarella). Section VII: Report of the Evaluators (E.C. Creutz et al.). Index.

Preservation of Moduli of Continuity for BersteinType Operators (J.A. Adell, J. de la Cal). Lp-Korovkin Type Inequalities for Positive Linear Operators (G.A. Anastassiou). On Some ShiftInvariate Integral Operators, Multivariate Case (G.A. Anastassiou, H.H. Gonska). Multivariate Probabalistic Wavelet Approximation (G. Anastassiou et al.). Probabalistic Approach to the Rounding Problem with Applications to Fair Representation (B. Athanasopoulos). Limit Theorums for Random Multinomial Forms (A. Basalykas). Multivariate Boolean Trapezoidal Rules (G. Baszenski, F.J. Delvos). Convergence Results for an Extension of the Fourier Transform (C. Belingeri, P.E. Ricci). The Action Constants (B.L. Chalmers, B. Shekhtman). Bivariate Probability Distributions Similar to Exponential (B. Dimitrov et al.). Probability, Waiting Time Results for Pattern and Frequency Quotas in the Same Inverse Sampling Problem Via the Dirichlet (M. Ebneshahrashoob, M. Sobel). 25 additional articles. Index.

Scalar Fields in Particle Physics and Cosmology; S. Rudaz. The Quark Mixing Matrix and CP Violation; C. Jarlskog. Pinning Down the Standard Model; F. Dydak. Issues in B Physics; M.V. Danilov. The Search for the Top Quark at the Tevatron; P.L. Tipton. Detection of Dark Matter and Solar Neutrinos; M. Spiro. Recent Developments in Tracking Detectors; D.H. Saxon. Experimental Challenges at Future Hadron Colliders; J. Siegrist. Technical Challenges of the LHC/SSC Colliders; D.A. Edwards. Index.

Femto-second Probing of Photoinduced Refractive Index Charges in Semiconductor; H.M. Van Driel, E.C. Fox. Tunneling of Electrons and Holes in Asymmetries Double Quantum Wells; J. Shah, et al. Ultrashort Excitation in Semiconductors; W.E. Bon. Contact-Free Characterization of Electronic and Optoelectronic Devices with Ultrashort Laser Pulses; J. Kuhl. Vibrational Relaxation Studied with Light; A. Lagendijk. Relaxation of Frenkeltype Rotational and Vibrational Excitons in Diatomic Molecular Crystals; E. Goovaertz. Quantum Transient Transport; C. Jacoboni, F. Rossi. Study of Irreversible Processes in Condensed Matter by Nonlinear Time and Space Resolved Techniques; Chr. Flytzanis. Index.

Overview: Big Bang in the Laboratory; H.H. Gutbrod, J. Rafelski. Physics of Relativistic Nuclear Collisions; I. Otterlund. Towards the LHC; P. Giubellino. Hot Hadronic Matter: Fireball Spectra; U. Heinz, et al. Quark Matter in Equilibrium; F. Karsch. Towards Dynamical Theoretical Description: Cascade Models and Particle Production; J. Cugnon. Relativistic Hydrodynamics and Flavor Flow; L. Csernai, et al. Quark-Gluon Plasma Formation in UltraRelativistic Heavy Ion Collisions; K. Geiger. Diagnostic Methods and Recent Results: A Pedestrian's Guide to Particle Interferometry; W.A. Zajc. Strangeness in Ultrarelativistic NucleusNucleus Collisions; E. Quercigh. On the Trail of Quark-Gluon Plasma; J. Rafelski. Epilogue: The Quark-Gluon Plasma; P.A. Carruthers. 20 additional articles. Index.

Chaotic Dynamics: Theory: Complexity, Control and Data Representation: Complexity and Unpredictable Scaling of Hierarchical Structures; R. Badii. Fractals, Multifractals, and Analyticity of Normal Forms: Multifractal Coding Measures in Dynamics; G. Mantica. Integrability, Painlevé Property, and Singularity Analysis: Note on a Complex Eckhaus Equation; M.F. Jorgensen, et al.. Statistical Physics, Celestial Mechanics, and Cosmology: Phase Transitions Within the Fully Developed Regime; R. Kluiving. Chaotic Dynamics: Practice: Controlling Dynamical Systems: Feedback Control of Chaotic Systems; . Romeiras et al.. Semiconductors, Superconductors, Lasers, and Electronic Circuits: Chaotic Dynamics in Practice; E. Del Rio, et al . Biology, Chemistry, Atmospheric, and Magnetospheric Dynamics: Irregular Bursting in Model Neurones; J. Hyde. Hamiltonian Dynamics, Dissipative Dynamics, and Normal Forms. 30 additional articles. Index.

2D Gravity and Non-Perturbative Effects: Diffusion Equation, Continuum Limit and Universality in 2D Quantum Gravity; O. Alvarez, et al. On Triangles and Squares; C. Bachas. Non-Perturbative Effects in 2D Gravity and Matrix Modles; F. David. Integrable Models of 2D Quantum Gravity; P. Di Francesco, et al. Topological Strings and Loop Equations; R. Dijkgraaf, et al. The Two Matrix Model; M.R. Douglas. Action Principle and Large Order Behavior of Non-Perturbative Gravity; P. Ginsparg, et al. D = 1 Strings and String Field Theory: Matrix Models, String Field Theory and Topology; T. Banks. Multipoint Correlation Functions in One-Dimensional String Theory; D. Boulativ. The Penner Model and D = 1 String Theory J. Distler, et al. Non-Perturbative String Theory; D.J. Gross. Bosonic Strings and String Field Theories in One-Dimensional Target Space; V. Kazakov. Liouville Theory andD 1: Random Surfaces in Dimensions Larger than One; J. Ambjorn. On Gauge Invariances in Stochastic Quantization; L. Baulieu. The Quantum Group Structure of Quantum Gravity in Two Dimensions; J.L. Gervais. Notes on Quantum Liouville Theory and Quantum Gravity; N. Seiberg. 8 additional articles. Index.

Opening Lecture.- The Champions of the Universe.- Theoretical Lectures.- Dark Matter.- Polarized Electroproduction and the Spin of the Quarks inside the Proton.- Quantum Chromodynamics of Hadron Jets.- Considerations on the Moduli Space of Calabi-Yau Manifolds.- Exotic Signatures from Supersymmetry.- Baby Universes and the Cosmological Constant Problem.- Recent Ideas on the Cosmological Constant Problem.- Review Lectures.- Quantum Strings and the Constants of Nature.- The LAA Project - Second Year of Activity.- Seminars on Specialized Topics.- A Crucial Test for QCD: The Time-like E.M. Form Factors of the Neutron.- Challenges to Quantum Chromodynamics: Anomalous Spin, Heavy Quark, and Nuclear Phenomena.- Prizes and Scholarships.- Participants.

Taylor-Couette Flow, Experiment and Theory: Evolution of Instrumentation for Taylor-Couette Flow; R.J. Donnelly. Phase Dynamics in the Taylor-Couette System; M. Wu, C.D. Andereck. Taylor-Couette Flow Systems with Broken Rotational Symmetry: End Circulation in Non-Axisymmetrical Flows; C. Normand et, al. Turbulence in Taylor-Couette and Plane Couette Flow: Numerical Simulation of Turbulent Taylor-Couette Flow; S. Hirschberg. Instabilities, Pattern Formation, and Turbulence in Model Equations: Double Eigenvalues and the Formation of Flow Patterns; R. Meyer-Spache. Extensions of Taylor-Couette Flow: Taylor Vortex Flow with Superimposed Radial Mass Flux; K. Buehler. Open Flows: Structure and Perturbation in Gortler Vortex Flow; P. Petitjeans, J.E. Wesfreid. Appendix: A Guide to Literature Related to the Taylor-Couette Problem; R. Tagg. 24 additional articles. Index.

The Development of the Vascular System: Embryonic Development of Blood Vessels; F. Dieterlen-Liévre, L. Pardanaud. Regulation of Embryonic Blood Vessel; H. Drexler et al.. Biology of Endothelial Cells and Angiogenesis: Basic Fibroblast Growth Factor and Endothelial Cells; M. Presta, et al. Role of Integrinss in Endothelial Cell Function; E. Dejana, et al. Angiogenesis in Disease States: Angiogenesis and Neoplastic Transformation; P.M. Gullino. Tumor Induced Angiogenesis; J.L. Ambrus, et al. Promoters and Inhibitors of Angiogenesis: Brain Tumor Angiogenesis; C. Guerin, et al. Therapeutic Potential of Promoters and Inhibitors of Angiogenesis: On Promoter of Angiogenesis and Therapeutic Potential; P.M. Gullino. Methodology: Assays for Angiogenic Factors; J.B. Weiss. 23 additional articles. Index.

Evaluation of Flat versus Complex Terrain Models in Estimating Pollutant Transport and Deposition in Complex Terrain; M.W. Yambert, et al. Small Particle Deposition in Air Quality Modeling; R. Kapahi. Accounting for Wet Deposition in Incinerator Risk Assessments; A.A. Campbell, et al. Accounting for Dry Deposition in Incinerator Risk Assessments; C.C. Travis, et al. Gas-Particle Distribution and Atmospheric Deposition of Semivolatile Organic COmpounds; T.F. Bidleman. An Overview of Food Chain Impacts from Municipal Waste Combustion; H.A. Hattemer-Frey, et al. Current Studies on Human Exposure to Chemicals with Emphasis on the Plant Route; S. Paterson, et al. Airto-Leaf Transfer of Organic Vapors to Plants; E. Bacci, et al. Uptake of Organic Contaminants by Plants; C. Mc Farlane. Uncertainties in Estimating Chemical Degradation and Accumulation in the Environment; S.T. Washburn, et al. The Food Chain as a Source of Human Exposure from Municipal Waste Combustion: An Uncertainty Analysis; G. Belcher, et al. Assessing Multiple Pathway Exposures: Variability, Uncertainty, and Ignorance; T.E. McKone. Uncertainty Analysis: An Essential Component of Risk Assessment and Risk Management; R. Tyler, et al. 3 additional articles. Index.

Some Problems in Limb Development.- The Molecular Basis of Limb Patterning: A Review.- Expression of the Msh-like Homeobox-containing Genes During Mouse Limb Development.- The Limb Deformity Gene Encodes Evolutionarily Highly Conserved Proteins.- The Role of Homeobox Genes in Amphibian Limb Development and Regeneration.- Homeobox-Containing Genes and Gap Junctional Communication in Pattern Formation During Chick Limb Development.- Functional Studies of Genes in the Limb.- Hox-7: Temporal Patterns of Expression in Normal and Limbless Chick Embryos.- Expression Profile of Two Homeobox Genes During Chicken Embryogenesis.- Characterisation of Three Zebrafish Genes Related to Hox-7.- A Comparison of the Expression Domains of the Murine Hox-4, RARs and CRABP Genes Suggest Possible Functional Relationships During Patterning of the Vertebrate Limb.- Retinoic Acid Nuclear Receptors.- The Role of Retinoic Acid and Cellular Retinoic Acid-Binding Protein in the Regenerating Amphibian Limb.- Retinoic Acid Treatment Alters the Pattern of Retinoic Acid Receptor Beta Expression in the Embryonic Chick Limb.- Expression Pattern of an RXR Nuclear Receptor Gene in the Chick Embryo.- Retinoic Acid and Limb Pattern Formation in Cell Culture.- Growth Factors Produced by the Polarising Zone - a Complement to the Retinoic Acid System.- Biochemical and Molecular Aspects of Retinoid Action in Limb Pattern Formation.- Position-Dependent Properties of Limb Cells.- Retinoic Acid and Limb Patterning and Morphogenesis.- Does Retinoic Acid Organise a Limb or Induce a ZPA?.- Retinoic Acid Effects on Experimental Chick Wing Buds: Patterns of Cell Death and Skeletogenesis.- A Comparison of Reaction Diffusion and Mechanochemical Models for Limb Development.- The Pathway of Polarising Activity from Hensen's Node to the Wing Bud in the Chick Embryo.- Extracellular Matrix in Early Limb Development.- Molecular Heterogeneity of Chondroitin Sulphate in the Developing Chick Limb.- Special Properties of the AER/Mesenchyme Interface in the Chick Wing Bud: Analysis of ECM Molecules and Integrin Receptors.- Physical Forces and Pattern Formation in Limb Development.- Extracellular Material Organization and Long Tendon Formation in the Chick Leg Autopodium. In Vivo and In Vitro Study.- Hyaluronan-Cell Interactions in Limb Development.- The Role of the Transforming Growth Factor-ß (TGF-ß) Family, Extracelluiar Matrix and Gap Junctional Communication in Limb Cartilage Differentiation.- Vascular Involvement in Cartilage and Bone Development.- Patterning of Connective Tissues in the Regenerating Amphibian Limb.- The Interdigital Spaces of the Chick Leg Bud as a Model for Analysing Limb Morphogenesis and Cell Differentiation.- A "Packaging Model" of Limb Development.- The Somite-Muscle Relationship in the Avian Embryo.- Observations Concerning the Control of Directed Myogenic Cell Migration.- Extracellular Matrix and Muscle Formation.- Control of Muscle Morphogenesis and Endplate Pattern in Limb Muscles of Avian Chimeras.- Review of the Extracellular Matrix in Relation to Limb Development.- Evolution of Connective and Skeletal Tissues.- Developmental Approaches to the Problem of Transformation of Limb Structure in Evolution.- New Palaeontological Contributions to Limb Ontogeny and Phylogeny.- The Fin-Limb Transformation: Palaeontological and Embryological Evidence.- The Development of the Teleost Fin and Implications for our Understanding of Tetrapod Limb Evolution.- Phylogenetically Ancient Pattern in Ontogenesis of Limb Muscles.- Mutation and Limb Evolution.- Insights into Limb Development and Pattern Formation from Studies of the Limbless and Talpid2 Chick Mutants.- Proximal Elements in the Vertebrate Limb: Evolutionary and Developmental Origin of the Pectoral Girdle.- Evolutionary Transformation of Limb Pattern: Heterochrony and Secondary Fusion.- Plasticity in Skeletal Development: Knee-Joint Morphology in Fibula-Deficient Chick Embryos.- The Implications of "The Bauplan" f

Characterization of Gene and Protein Structure.- Biosynthesis and Assembly of the Factor VIII-von Willebrand Factor Complex.- Factor IX: Gene Structure and Protein Synthesis.- Antithrombin III Genetics, Structure and Function.- Interactions Between the Functional Domains of Antithrombin III.- Protein C: Gene Structure and Protein Synthesis.- Structural and Functional Properties of Protein C.- Molecular Defects Affecting Hemostasis.- Molecular Defects in Hemophilia A.- Molecular Defects in Hemophilia B.- Molecular Defects in Human Antithrombin III Deficiency.- The Biologic Impact of Hereditary Defects that Cause Thrombosis.- Protein Production by Recombinant Technology.- Factors Limiting Expression of Secreted Proteins in Mammalian Cells.- Synthesis of Biologically Active Vitamin K-Dependent Coagulation Factors.- The Expression of Therapeutic Proteins in Transgenic Animals.- Clinical use of Proteins Produced by Recombinant Technology.- The Use of Animal Models to Evaluate Proteins Produced by Recombinant Technology.- Experiences with Recombinant Factor VIIa in Hemophiliacs.- Clinical Trials of Factor VIII Produced by Recombinant Technology.- Clinical Trials of Recombinant Factor VIII.- Concluding Overview.- The Impact of Recombinant Technologies in Understanding Plasma Proteins Important for Hemostasis and Thrombosis.- Contributors.

Free Radicals/Ischemia Reperfusion Injury: Basal Relief of EDRF under Conditions of Oxidant Stress; N. Marczin, et al. Invasion and Neoplasia: Interaction of Malaria-Infected Cells with the Vascular Wall; G. Senaldi, et al. EndothelialTumor Cell Interactions In vitro and In vivo; R. Giavazzi, et al. Altered Vascular Reactivity: Altered Vascular Reactivity in Coronary Artery Disease; J. Zanzinger, E. Bassenge. Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cycle GMP Signal Transduction System; F. Murad, et al. Inflamation/Atherosclerosis: Proinflammatory Role of Leukocyte Adhesion Molecules; J.M. Harlan, et al. Circulating Endothelial Adhesion Molecules; J.L. Gordon, et al. Organ Transplantation/Rejection: Experimental Cell Transplantation and Gene Therapy Techniques in the Treatment of Liver Disease; A.A. Demetriou, et al. 6 additional articles. Index.

Physiology and Metabolism: Genetic Influences on Urinary Calcium Excretion (R.P. Holmes et al.). Oxalate Metabolism and Transport: Vectorial Oxalate Transport across a Monolayer of Renal Epithelial Cells (H. Koul et al.). Physicochemistry, Promoters and Inhibitors: Crystal Growth and Nucleation Rates for Calcium Oxalate in 92% Fresh Urine in a Continuous Crystalliser (J.P. Kavanagh et al.). Crystallization and Proteins: Possible Role of Stone Matrix in Calcium Oxalate Stone Formation (S. Yamaguchi et al.). Stone Composition, Matrix and Membranes: Role of Organic Matrix in Formation and Growth of Calcium Oxalate Urinary Stones (S.R. Khan, R.L. Hackett). Risk Factors and Diet: Urinary Silicate in Calculous Patients (W.C. Thomas). Epidemiology and Infection: Urinary Enzymes (C.H. van Aswegen et al.). ESWL and Lithotropsy: Ultrasound Velocity-A Measure of Stone Strength? (N.P. Cohen et al.). Investigation, Medical and Surgery Management: A New Therapeutic Agent for Cystinuria (T. Koide et al.). 276 additional articles. Index.

Dendritic Cells; J.M. Austyn. The Multiple Accessory Cell Concept; M. Van Rooijen. Sythetic Peptides and the Role of T-Helper Cell Determinants; M.J. Francis. Carriers for Peptides; M.J. Francis. Co-Entrapment of T-Cell and B-Cell Peptides in Liposomes Overcomes Genetic Restriction in Mice and Induces Immunological Memory; G. Gregoriadis, et al. Preparation and Characterization of Stable Liposomal Hepatitis B Vaccine; D. Diminsky, et al. Initiation of Immune Response with ISCOM; B. Morein, et al. Nanoparticles as Potent Aduvants for Vaccines; J. Kreuter. Optimization of Carriers and Adjuvants; A. Snidjders, et al. Immunotargeting as an Adjuvant Independent Subunit Vaccine Design Option; D.L. Skea, B.H. Barber. BCG Vaccine; M.J. Groves, et al. Significance of Virulence Factors and ImmunoEvasion for the Design of Gene-Deleted Herpesvirus Marker Vaccines; S. Kit. Eradication of Sylvatic Rabies Using a Live Recombinant Vaccinia-vRabies Vaccine; M.P. Kieny, et al. 7 additional articles. Index.