Bøger i Advances in Experimental Medic serien

The meeting of Aquatic Noise 2013 will introduce participants to the most recent research data, regulatory issues and thinking about effects of man-made noise and will foster critical cross-disciplinary discussion between the participants. Emphasis will be on the cross-fertilization of ideas and findings across species and noise sources. As with its predecessor, The Effects of Noise on Aquatic Life: 3rd International Conference will encourage discussion of the impact of underwater sound, its regulation and mitigation of its effects. With over 100 contributions from leading researchers, a wide range of sources of underwater sound will be considered.

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

This volume contains the Proceedings of a two-week course on "Laser Applications to Biology and Medicine" held from September 4 to 16, 1983 in Erice, Italy. This is the 10th annual course of the International School of Quantum Electronics organized under the auspices of the "E. Majorana" Center for Scientific Culture. ,Among the possible approaches to a course on Laser Applications to Biology and Medicine, the one which emphasizes the scientific and technological aspects of the advanced laser techniques when applied to laboratory and clinical tests has been chosen. In fact, it reflects the new policy of the School to stress the advanced scien­ tific and technological achievements in the field of Quantum Elec­ tronics. Accordingly, the Course has given the broadest information on the ultimate performances already achieved and the perspectives of their applications. Because of the great variety of applications of laser in biology, medicine, chemistry, engineering and related branches of science, this school addressed a subject of interdisciplinary interest. The formal sessions have been balanced between tutorial presentations and lectures focusing on unsolved problems and future directions. In addition, wide time has been provided for the par­ ticipants to meet together informally for additional discussions on the forefront of current work. Therefore the character of the Course was a blend of current research and tutorial reviews.

This volume contains the proceedings of a conference held in Freiburg, West Germany, September 22-25, 1980, entitled "Manned Systems Design, New Methods and Equipment". The conference was sponsored by the Special Programme Panel on Human Factors of the Scientific Affairs Division of NATO, and supported by Panel VIII, AC/243, on "Human and Biomedical Sciences". Their sponsorship and support are gratefully acknowledged. The contributions in the book are grouped according to the main themes of the conference with special emphasis on analytical approaches, measurement of performance, and simulator design and evaluat ion. The design of manned systems covers many and highly diversified areas. Therefore, a conference under the general title of "Manned Systems Design" is rather ambitious in itself. However, scientists and engineers engaged in the design of manned systems very often are confronted with problems that can be solved only by having several disciplines working together. So it was felt that knowledge about newly developed methods and equipment, applicable in the design process, is of common and increasing interest for all those who are engaged in the design of manned systems, from the earliest con­ ceptual design phases until operation under real circumstances. This seems to be particularly true in view of restricted resources of manpower and energy.

This book summarizes the recent advancements for visualized medicine in terms of fundamental principles, rapidly emerging techniques and developing frontiers. Especially with the combination of artificial intelligence (AI), medical imaging agents and medical robots, smart medical technologies have been innovated and applied to the clinical uses to serve the fatal human diseases diagnosis, treatment, prognosis and data analysis. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare, and will enable precision medicine and precision surgery further intuitively detectable, smartly analyzable and accurately operational. This book will discuss and conclude: 1) state-of-the-art definition of visualized medicine; 2) advanced techniques and clinical applications of visualized medicine in the past decade; 3) novel frontiers and brand-new technologies, e.g. artificial intelligence (AI), surgical robots, etc. 4) revolutionary impacts on disease diagnosis, treatments and prognosis; 5) future challenges and perspectives.

This volume is a report of the proceedings of the Third International Nephro-Lrological Course held in the Ettore Majorana Centre for Scientific Culture, Erice, Sicily, from 12th to 18th May 1980. Contributions were accepted on the understanding that the editors could make certain changes leading towards a uniformity of style but accepting as a Driority the importance of early publi­ cation, if necessary at the expense of stylistic perfection. The meeting, directed by A. Vercellone (Torino), R. Maiorca (Brescia) and M. Pavone-Macaluso (Palermo), was sponsored by: the Italian Associations of Nephrology, Immunology and Urology; the Ministries of Scientific Research and Public Education of the Republic of Italy; the Sicilian Regional Government; the National Research Council and the University of Palermo. Immunologic problems in renal disease Rnd metabolic and medical aspects of urolithiasis were the two subjects of the Congress, which was attended by numerous invi~ed speakers and participants. The first part was introduced by A. Vercellone (Torino), who discussed the major steps in the development and the present per­ spectives of nephrology, a relatively newly born science, recognized as such only in 1960. He called attention to the great significance of our present knowledge of the immunologic mechanisms (circulating immune complexes or in situ mounting, cellular immunity, activation of complement) which are involved in the pathogenesis of glomerulo­ nephritis.

This book gathers relatively recent and significant topics in the field of ion channel research. Ion channels form the molecular basis for membrane excitability in cells present in the cardiovascular and nervous systems. In many non-excitable cells, ion channels contribute to diverse physiological functions, including the secretion of signaling compounds like hormones and insulin, cell volume regulation, intracellular signaling, especially Ca2+ signaling, etc. Many human diseases have been attributed to abnormal channel functions and defective membrane expression of channel proteins. On the other hand, ion channels are excellent models for studying protein biophysics, especially the allosteric regulation of protein function by miscellaneous stimuli. Therefore, research on ion channels carries significant meaning for the understanding of basic protein biophysics and diverse physiological functions. Such vital information also assists in developing novel and effective treatments for related human diseases. This book provides graduates and scientists in both basic and clinical levels a comprehensive understanding of cutting-edge advances and a useful and stimulating platform for tackling their own questions about ion channels.